METFORMIN-D6, HYDROCHLORIDE

Base Information

• Chemical Name: METFORMIN-D6, HYDROCHLORIDE
• CAS No.: 1185166-01-1
• Molecular Formula: C4H6ClD6N5
• Molecular Weight: 171.661550668
• Mol file: 1185166-01-1.mol

Synonyms:METFORMIN-D6, HYDROCHLORIDE;Diabetosan-d6;Diabex-d6, Glucophage-d6;Metiguanide-d6;N,N-Dimethylimidodicarbonimidic Diamide-d6, Hydrochloride

Chemical Property of METFORMIN-D6, HYDROCHLORIDE

Chemical Property:

• Melting Point: 215-218°C
• PSA: 88.99000
• LogP: 1.05850
• Storage Temp.: -20°C Freezer
• Solubility.: Aqueous Acid (Slightly), DMSO (Slightly), Methanol (Slightly)

Purity/Quality:

NLT 98% ^*data from raw suppliers

Metformin-d6, Hydrochloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xn
• Hazard Codes: Xn
• Statements: 22-36/38
• Safety Statements: 26

MSDS Files:

SDS file from LookChem

Useful:

• Description: Metformin-d6 is intended for use as an internal standard for the quantification of metformin by GC- or LC-MS. Metformin is a biguanide with diverse biological activities. Metformin (250 mg/kg, i.p.) increases hepatic AMPK activity and reduces blood glucose by more than 50% in a liver kinase B1-dependent manner in mice fed normal and high-fat diets, respectively, and reduces blood glucose by 40% in ob/ob mice. It reduces weight gain, hepatic lipid droplet content, and total cholesterol, LDL cholesterol, and triglyceride levels in the plasma of diet-induced obese mice when administered at doses of 10 or 50 mg/kg per day. It also reverses increased hepatic triglyceride and apolipoprotein A5 levels, as well as hepatic steatosis, in a dose-dependent manner in an ob/ob mouse model of non-alcoholic fatty liver disease (NAFLD). Metformin (250 mg/kg) reduces tumor growth in an HCT116 p53-\- human colon cancer mouse xenograft model, but has no effect on HCT116 p53-\- tumors overexpressing recombinant S. cerevisiae Ndi1 NADH dehydrogenase, a single-subunit ortholog of the multi-subunit mammalian mitochondrial complex I. Formulations containing metformin have been used in the treatment of type 2 diabetes.
• Uses: An oral hypoglycemic agent.