1132660-78-6Relevant articles and documents
Synthesis and biological evaluation of 2-phenylquinolones targeted at Tat/TAR recognition
Manfroni, Giuseppe,Gatto, Barbara,Tabarrini, Oriana,Sabatini, Stefano,Cecchetti, Violetta,Giaretta, Giulia,Parolin, Cristina,Del Vecchio, Claudia,Calistri, Arianna,Palumbo, Manlio,Fravolini, Arnaldo
, p. 714 - 717 (2009)
Tat (transactivator of transcription) is a small HIV protein rich in arginines that interacts with a viral RNA structure called TAR (trans-activation responsive region). Tat-TAR interaction is essential for viral gene expression, replication and pathogene