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  • 112914-13-3 Structure
  • Basic information

    1. Product Name: 4-[(4-Fluorophenyl)methyl]-2-morpholinemethanamine
    2. Synonyms: C-[4-(4-FLUORO-BENZYL)-MORPHOLIN-2-YL]-METHYLAMINE DIHYDROCHLORIDE;2-Aminoethy-4-(4-Fluorobenzyl)-morpholine;2-(AminoMethyl)-4-(4-FluoroBenzyl)Morpholine,Mosapride;2-Aminomethy-4-(4-fluorobenzyl)morpholine;4-[(4-Fluorophenyl)methyl]-2-morpholinemethanamine;{4-[(4-fluorophenyl)Methyl]Morpholin-2-yl}MethanaMine;(4-(4-Fluorobenzyl)Morpholin-2-yl)MethanaMine;2-(Aminomethyl)-4-(4-fluorobenzyl)morpholine, 1-{[2-(Aminomethyl)morpholin-4-yl]methyl}-4-fluorobenzene
    3. CAS NO:112914-13-3
    4. Molecular Formula: C12H17FN2O
    5. Molecular Weight: 224.28
    6. EINECS: N/A
    7. Product Categories: Pharmaceutical Intermediates;Amines;Aromatics;Heterocycles;Intermediates & Fine Chemicals;Pharmaceuticals
    8. Mol File: 112914-13-3.mol
    9. Article Data: 7
  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: 317.439 °C at 760 mmHg
    3. Flash Point: 145.782 °C
    4. Appearance: /
    5. Density: 1.145 g/cm3
    6. Vapor Pressure: 0mmHg at 25°C
    7. Refractive Index: 1.535
    8. Storage Temp.: Refrigerator
    9. Solubility: N/A
    10. PKA: 9.37±0.29(Predicted)
    11. CAS DataBase Reference: 4-[(4-Fluorophenyl)methyl]-2-morpholinemethanamine(CAS DataBase Reference)
    12. NIST Chemistry Reference: 4-[(4-Fluorophenyl)methyl]-2-morpholinemethanamine(112914-13-3)
    13. EPA Substance Registry System: 4-[(4-Fluorophenyl)methyl]-2-morpholinemethanamine(112914-13-3)
  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 112914-13-3(Hazardous Substances Data)

112914-13-3 Usage

Chemical Properties

Clear Pale Yellow Oil

Uses

Mosapride intermediate.

Check Digit Verification of cas no

The CAS Registry Mumber 112914-13-3 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,1,2,9,1 and 4 respectively; the second part has 2 digits, 1 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 112914-13:
(8*1)+(7*1)+(6*2)+(5*9)+(4*1)+(3*4)+(2*1)+(1*3)=93
93 % 10 = 3
So 112914-13-3 is a valid CAS Registry Number.
InChI:InChI=1/C12H17FN2O/c13-11-3-1-10(2-4-11)8-15-5-6-16-12(7-14)9-15/h1-4,12H,5-9,14H2

112914-13-3SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 17, 2017

Revision Date: Aug 17, 2017

1.Identification

1.1 GHS Product identifier

Product name 4-[(4-Fluorophenyl)Methyl]-2-Morpholinemethanamine

1.2 Other means of identification

Product number -
Other names (4-(4-Fluorobenzyl)morpholin-2-yl)methanamine

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:112914-13-3 SDS

112914-13-3Relevant articles and documents

Method for preparing mosapride citrate intermediate

-

, (2018/07/06)

The invention belongs to the technical field of medicines and particularly relates to a method for preparing a mosapride citrate intermediate IV 4-(4-fluorophenyl)-2-aminomethyl morpholine. The methodcomprises the following steps: phthalimide potassium salt and dichloro-2-propanol react to produce an intermediate II N-(2-hydroxy-3-chloropropyl) phthalimide, then the produced intermediate II and an intermediate I 2-(4-fluorphenylamine)ethyl alcohol are condensed to prepare an intermediate III N-3-[4-fluorophenyl-2-(hydroxy-ethylamine)-2-hydroxypropyl]phthalic diamide, and the intermediate IIIis subjected to cyclization and hydrolysis to obtain the intermediate IV 4-(4-fluorophenyl)-2-aminomethyl morpholine. The method is short in route, lower in production cost and suitable for industrialproduction.

PROCESS FOR THE SYNTHESIS OF A BENZAMIDE DERIVATIVE

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Page 10-11, (2010/02/04)

The invention relates to a process for the synthesis of mosapride citrate of formula (I), the chemical name: (R,S)-4-amino-5-chloro-2-ethoxy-N-{ [4-(4-fluoro-benzyl)-2- morpholinyl]-methyl}benzamide citrate dihydrate, (I), (II) reacting the compound of formula (II) with di-tert-butyl-dicarbonate in an alcohol in the presence of a base, the obtained product is ethylated in an inert solvent in the presence of a base, the obtained compound is hydrolyzed with an alkyl-hydroxide and the obtained salt neutralized with an acid, the obtained product is chlorinated, and the obtained compound of formula (VI) is reacted with the compound of formula (VII), (VI), (VII) where BOC is tert-butoxy-carbonyl protecting group and removing the protecting group from the obtained compound of formula (VIII) the mosapride base is prepared, (VIII) where BOC is defined as above and in desired case with an acid, preferably with citric acid a pharmaceutically acceptable salt, preferably the mosapride citrate dehydrate of formula (I) is produced.

Synthesis and biological activity of 4-amino-5-chloro-2-ethoxy-3- hydroxybenzamides, metabolites of a new gastroprokinetic agent, mosapride

Kato, Shiro,Morie, Toshiya,Yoshida, Naoyuki

, p. 1484 - 1492 (2007/10/03)

To confirm the proposed structures of the minor metabolites of a potential gastroprokinetic agent, mosapride, 4-amino-5-chloro-2-ethoxy-3- hydroxy-N-(2-morpholinylmethyl)benzamide (3) and the N-(5-oxo-2- morpholinyl)methyl analogue 4 were prepared. As the

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