1118763-24-8

Basic information

• Product Name: 3-(adamantan-1-ylmethyl)-2-(2-chloro-6-fluorophenyl)thiazolidin-4-one
• CAS NO: 1118763-24-8
• Molecular Weight: 379.926
• Mol File: 1118763-24-8.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 3-(adamantan-1-ylmethyl)-2-(2-chloro-6-fluorophenyl)thiazolidin-4-one(CAS DataBase Reference)
• NIST Chemistry Reference: 3-(adamantan-1-ylmethyl)-2-(2-chloro-6-fluorophenyl)thiazolidin-4-one(1118763-24-8)
• EPA Substance Registry System: 3-(adamantan-1-ylmethyl)-2-(2-chloro-6-fluorophenyl)thiazolidin-4-one(1118763-24-8)

Safety Data

• Hazardous Substances Data: 1118763-24-8(Hazardous Substances Data)

Upstream product

• 17768-41-1 adamantylmethylamine 
• 387-45-1 2-chloro-6-fluorobenzaldehyde 
• 68-11-1 mercaptoacetic acid 

Relevant articles and documents

Synthesis and anti-HIV studies of 2- and 3-adamantyl-substituted thiazolidin-4-ones

A series of novel thiazolidin-4-ones bearing a lipophilic adamantyl substituent at position 2 or 3 were synthesized. A majority of them showed a modest anti-HIV-1 activity, whereas 2-adamantan-1-yl-3-(4,6-dimethylpyrimidin-2-yl)-thiazolidin-4-one (8) was endowed with a remarkable antiviral potency (EC50 = 0.67 μM). The new series of compounds (22-29) with an adamantyl moiety at the 3-position of the thiazolidinone ring showed good to modest anti-HIV-1 activity (EC50 = 1.0-11 μM) but also pronounced cytostatic activity. For example 24, 26 and 29 showed an EC50 of 1.0-2.0 μM, while the 50% effective concentrations for 23 and 28 were 7.8 and 11.0 μM, respectively. X-ray studies and quantum chemical calculations revealed that the anti-HIV activity of the compounds strongly depends on their dipole moments and conformation of the thiazolidinones.