111011-78-0 Usage
Uses
Used in Pharmaceutical Industry:
3-(5,5-dimethyl-2-oxo-1,3,2-dioxaphorinane-2-yl)-4-(3-nitrophenyl)-but-3-en-2-one is used as a key intermediate in the synthesis of pharmaceutical compounds for its unique reactivity and structural features. Its potential applications include the development of new drugs with improved efficacy and selectivity.
Used in Agrochemical Industry:
In the agrochemical sector, 3-(5,5-dimethyl-2-oxo-1,3,2-dioxaphorinane-2-yl)-4-(3-nitrophenyl)-but-3-en-2-one is utilized as a precursor in the production of agrochemicals, such as pesticides and herbicides. Its unique structure and reactivity contribute to the development of novel and effective agrochemicals with reduced environmental impact.
Used in Material Science:
3-(5,5-dimethyl-2-oxo-1,3,2-dioxaphorinane-2-yl)-4-(3-nitrophenyl)-but-3-en-2-one is employed as a building block in the synthesis of advanced materials with specific properties. Its incorporation into polymers, coatings, and other materials can lead to the development of innovative products with improved performance and functionality.
Used in Organic Chemistry Research:
Due to its unique structure and reactivity, 3-(5,5-dimethyl-2-oxo-1,3,2-dioxaphorinane-2-yl)-4-(3-nitrophenyl)-but-3-en-2-one is of significant interest for further research and development in the field of organic chemistry. It serves as a valuable tool for exploring new synthetic pathways, understanding reaction mechanisms, and discovering novel chemical transformations.
Check Digit Verification of cas no
The CAS Registry Mumber 111011-78-0 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,1,1,0,1 and 1 respectively; the second part has 2 digits, 7 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 111011-78:
(8*1)+(7*1)+(6*1)+(5*0)+(4*1)+(3*1)+(2*7)+(1*8)=50
50 % 10 = 0
So 111011-78-0 is a valid CAS Registry Number.
111011-78-0Relevant articles and documents
Synthesis of 1,4-dihydropyridine-5-phosphonates and their calcium-antagonistic and antihypertensive activities
Sakoda,Kamikawaji,Seto
, p. 2362 - 2369 (2007/10/02)
The effect of the 3-carboxylic-ester variation in 2,2-dimethyltrimethylene 3-alkoxycarbonyl-4-aryl-1,4-dihydro-2,6-dimethyl-5-pyridinephosphonate s (1) was investigated with relation to the calcium-antagonistic and antihypertensive activities: the analogs containing the alkyl groups of not more than 12 carbons and an amino functionality in the carboxylic-ester moiety were synthesized to be examined for biological activities. Among them, 2-[benzyl(phenyl)amino]-ethyl 5-(5,5-dimethyl-2-oxo-1,3,2-dioxaphosphorinan-2-yl)-1,4-dihydro-2,6-di methyl-4-(3-nitrophenyl)-3-pyridine-carboxylate hydrochloride ethanol (NZ-105) showed particularly beneficial activities and was selected for further pharmacological studies and clinical development. Some aspects of the structure-activity relationships and solid-state structure of NZ-105 by X-ray crystallographic analysis were described.
Synthesis and crystal structure of optically active 2-[benzyl(phenyl)amino]ethyl 5-(5,5-dimethyl-2-oxo-1,3,2-dioxaphosphorinan-2-yl)-1,4-dihydro-2,6-di methyl-4-(3-nitrophenyl)-3-pyidinecarboxylate (NZ-105)
Sakoda,Matsumoto,Seto
, p. 2377 - 2381 (2007/10/02)
(S)-2-[Benzyl(phenyl)amino]ethyl 5-(5,5-dimethyl-2-oxo-1,3,2-dioxaphosphorinan-2-yl)-1,4-dihydro-2,6-di methyl-4-(3-nitrophenyl)-3-pyridinecarboxylate ((S)-NZ-105) and R isomer were synthesized through the fractional crystallization of (S)-2-Methoxy-2-phenylethyl 5-(5,5-dimethyl-2-oxo-1,3,2-dioxaphosphorinan-2-yl)-1,4-dihydro-2,6-di methyl-4-(3-nitrophenyl)-3-pyridinecarboxylate. Calcium antagonism activity was found to reside in the S isomer from single crystal X-ray diffraction analysis
