108-52-1 Usage
Description
2-Amino-4-methylpyrimidine is an organic compound that plays a significant role in the study of anaerobic acetone activation by Desulfococcus biacutus. It is formed as a product of a reaction between acetoacetaldehyde and guanidine. This off-white to light brown crystalline powder possesses unique chemical properties that make it a valuable subject of research in various scientific fields.
Uses
Used in Chemical Research:
2-Amino-4-methylpyrimidine is used as a key compound in the study of anaerobic acetone activation by Desulfococcus biacutus. Its formation as a product of the reaction between acetoacetaldehyde and guanidine provides valuable insights into the metabolic processes and enzymatic reactions involved in this biological system.
Used in Pharmaceutical Development:
Due to its unique chemical properties, 2-Amino-4-methylpyrimidine has potential applications in the development of pharmaceuticals. Its ability to participate in various chemical reactions and form stable compounds makes it a promising candidate for the synthesis of new drugs and therapeutic agents.
Used in Biochemical Studies:
2-Amino-4-methylpyrimidine's role in the anaerobic acetone activation process highlights its potential use in biochemical studies. Researchers can utilize this compound to further understand the mechanisms of enzymatic reactions, metabolic pathways, and the role of various microorganisms in these processes.
Synthesis Reference(s)
Journal of the American Chemical Society, 73, p. 3526, 1951 DOI: 10.1021/ja01151a529
Purification Methods
Crystallise the pyrimidine from H2O or EtOH and sublime it in a vacuum. The picrate crystallises from EtOH and has m 235-236o(dec). [Beilstein 24 H 84, 25 III/IV 2152.]
Check Digit Verification of cas no
The CAS Registry Mumber 108-52-1 includes 6 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 3 digits, 1,0 and 8 respectively; the second part has 2 digits, 5 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 108-52:
(5*1)+(4*0)+(3*8)+(2*5)+(1*2)=41
41 % 10 = 1
So 108-52-1 is a valid CAS Registry Number.
InChI:InChI=1/C6H8N2/c1-5-3-2-4-8-6(5)7/h2-4H,1H3,(H2,7,8)
108-52-1Relevant articles and documents
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Svackin et al.
, (1968)
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Preparation of pyrrole and pyrrolidine derivatives of pyrimidine. 1-(2-Pyrimidinyl)pyrrole - An inhibitor of X. Phaseoli and X. Malvacearum
Becker, Irwin
, p. 343 - 348 (2004)
Pyrrole and pyrrolidine derivatives of pyrimidine were prepared in which the nitrogen atom of the pyrrole or pyrrolidine ring is bonded directly to the 2- or 4-carbon atom of the pyrimidine ring. Pyrrole derivatives were prepared by the dry distillation of an intimate mixture of an aminopyrimidine with mucic acid and by the reaction of a chloropyrimidine with potassium pyrrole. Pyrrolidine derivatives were prepared by the reaction of a chloropyrimidine with pyrrolidine and, in a single instance, by the catalytic hydrogenation of a pyrimidinylpyrrole. At a concentration of 200 mcg/mL, 1-(2-pyrimidinyl)pyrrole inhibited two plant pathogenic bacteria -Xanthomanus phaseoli (pathogenic on the bean plant) and Xanthomanus malvacearum (pathogenic on the cotton plant).
MECHANISTIC TARGET OF RAPAMYCIN SIGNALING PATHWAY INHIBITORS AND THERAPEUTIC APPLICATIONS THEREOF
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Paragraph 00187; 00188, (2018/04/11)
Selective mTOR inhibitors of formulas (I)-(III), processes for their preparation, pharmaceutical compositions containing them, and their use in the treatment of diseases and disorders, arising from abnormal cell growth, functions, or behaviors mediated by an mTOR kinase and/or one or more PI3K enzyme, are provided. Such diseases and disorder include cancer, immune disorders, cardiovascular disease, viral infection, inflammation, metabolism/endocrine function disorders and neurological disorders.
SUBSTANCES FOR DYEING KERATINOUS FIBERS
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, (2010/03/04)
Disclosed are substances which contain unsaturated, non-aromatic dialdehydes of formula (Ia) and/or the tautomer (Ib) thereof, wherein R1, R2, and R3 are defined as indicated in claim 1, along with at least one CH-acidic compound of formulas (II) and/or (III), wherein R6, R7, R8, R9, R10, Y, X?, Het, and X1 are defined as indicated in claim 1, in a cosmetic carrier. Said substances color keratinous fibers, especially human hair, in an intensive, colorfast, natural brown shade.
