10242-12-3 Usage
Description
5-Nitrobenzofuran-2-carboxylic acid is a light yellow powder that serves as a versatile reagent in the synthesis of various organic compounds, particularly arylamidobenzofurans. It is a key reactant in the preparation of different pharmaceutical agents and has demonstrated potential applications in the development of novel drugs.
Uses
Used in Pharmaceutical Industry:
5-Nitrobenzofuran-2-carboxylic acid is used as a reactant for the synthesis of arylamidobenzofurans via Curtius rearrangement, bromination, and Suzuki reaction. These compounds have potential applications in the development of new drugs.
Used in Antibacterial Applications:
5-Nitrobenzofuran-2-carboxylic acid is used as a reactant in the synthesis and antibacterial evaluation of nitazoxanide-based analogs. These analogs show promise in the development of new antibacterial agents.
Used in Hormone Regulation:
5-Nitrobenzofuran-2-carboxylic acid is used as a reactant in the preparation of Melanin-Concentrating Hormone Receptor 1 (MCHR1) antagonists. These antagonists have potential applications in the treatment of various disorders related to hormone regulation.
Used in Antitumor Agents:
5-Nitrobenzofuran-2-carboxylic acid is used as a reactant in the synthesis of benzoyl and cinnamoyl nitrogen mustard derivatives of benzoheterocyclic analogs of tallimustine. These compounds are being investigated as potential antitumor agents.
Used in Organic Synthesis:
5-Nitrobenzofuran-2-carboxylic acid is used as a reagent in the synthesis of various organic compounds, contributing to the development of new materials and chemicals in the chemical industry.
Check Digit Verification of cas no
The CAS Registry Mumber 10242-12-3 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 1,0,2,4 and 2 respectively; the second part has 2 digits, 1 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 10242-12:
(7*1)+(6*0)+(5*2)+(4*4)+(3*2)+(2*1)+(1*2)=43
43 % 10 = 3
So 10242-12-3 is a valid CAS Registry Number.
InChI:InChI=1/C9H5NO5/c11-9(12)8-4-5-3-6(10(13)14)1-2-7(5)15-8/h1-4H,(H,11,12)/p-1
10242-12-3Relevant articles and documents
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Erlenmeyer et al.
, p. 75 (1948)
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[...] intermediate synthetic method (by machine translation)
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Paragraph 0032; 0033; 0034; 0035; 0036; 0037, (2018/04/01)
The invention relates to a [...] intermediate synthesis method, in order to 6 - nitro coumarin as the starting the raw materials, through ring-opening, the ring in the molecule, esterification, reduction, paipai qin link other steps, to obtain key [...] middle style I compound 5 - (1 - piperazinyl) - 2 - benzofuran - 2 - carboxylic acid ethyl ester. The invention synthetic route is simple, the target product yield is relatively high, and is suitable for industrial scale production. (by machine translation)
1-(CYCLOALKYL-CARBONYL)PROLINE DERIVATIVE
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Paragraph 0518, (2015/06/03)
A compound represented by formula (1) (in the formula: ring-D represents a three- to eight-membered hydrocarbon ring; Ra represents an optionally substituted amino C1-6 alkyl group or the like; Rb1 and Rb2 each independently represent a hydrogen atom, a halogen atom, or the like; Rc represents an optionally substituted C6-10 aryl group or the like; Rd represents a hydrogen atom or the like; and ring-Q represents a (hetero)aryl group or the like which may be substituted with a carboxyl group or the like) or a pharmaceutically acceptable salt thereof exhibits an excellent FXIa inhibitory activity, and is useful as a therapeutic agent against thrombosis or the like.
