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| CAS No.: | 99189-60-3 |
|---|---|
| Name: | 1,1-Cyclohexanediacetic acid mono amide |
| Article Data: | 11 |
| Molecular Structure: | |
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| Formula: | C10H17NO3 |
| Molecular Weight: | 199.25 |
| Synonyms: | Cyclohexaneaceticacid, 1-(carbamoylmethyl)- (6CI);1,1-Cyclohexanediacetic acid monoamide;1-(Carboxymethyl)cyclohexane-1-acetamide;1-[(Aminocarbonyl)methyl]cyclohexaneacetic acid; |
| EINECS: | 449-430-4 |
| Density: | 1.135 g/cm3 |
| Melting Point: | 143-146 °C |
| Boiling Point: | 443.6 °C at760mmHg |
| Flash Point: | 222.1 °C |
| Appearance: | White powder |
| Hazard Symbols: | T |
| Risk Codes: | 61 |
| Safety: | 22-24/25 |
| PSA: | 80.39000 |
| LogP: | 1.98730 |
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- 99662-46-1triphenyl(2-pyridylmethyl)phosphonium chloride hy
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- 99783-85-41-(3-hydroxy-4-methoxyphenyl)-3-methylbutan-1-one
- 1130-32-1
3-azaspiro[5,5]undecane-2,4-dione
- 99189-60-3
[1-(2-amino-2-oxoethyl)cyclohexyl]acetic acid
| Conditions | Yield |
|---|---|
| With water; sodium hydroxide at 50℃; for 6h; Reagent/catalyst; | 93% |
| With sodium hydroxide | |
| Stage #1: 3-azaspiro[5.5]undecane-2,4-dione With sodium hydroxide; water at 95 - 105℃; for 6h; Heating / reflux; Stage #2: With hydrogenchloride In water; isopropyl alcohol at 20 - 40℃; for 1h; pH=6.5; Industry scale; Stage #3: With hydrogenchloride In water; isopropyl alcohol at 35 - 40℃; for 1h; pH=4.0 - 4.5; Industry scale; | |
| Stage #1: 3-azaspiro[5.5]undecane-2,4-dione With sodium hydroxide; water for 1h; Heating / reflux; Stage #2: With hydrogenchloride In water at 25℃; pH=5; |
- 90961-78-7
spiro[cyclohexane-1,9’-(3,7-diazabicycle-[3.3.1]nonane)]-2’,4’,6’,8’-tetraone
- 99189-60-3
[1-(2-amino-2-oxoethyl)cyclohexyl]acetic acid
| Conditions | Yield |
|---|---|
| With water; sodium hydroxide at 100 - 105℃; for 18h; | 80.8% |
- 1010-26-0
1,1-cyclohexanediacetic acid anhydride
- 99189-60-3
[1-(2-amino-2-oxoethyl)cyclohexyl]acetic acid
| Conditions | Yield |
|---|---|
| Stage #1: 1,1-cyclohexanediacetic acid anhydride With ammonia In water; acetic acid; toluene at 10 - 30℃; for 1.33333h; pH=> 8; Stage #2: With hydrogenchloride In water at 40 - 45℃; for 0.333333h; pH=3.8 - 4.2; | |
| Stage #1: 1,1-cyclohexanediacetic acid anhydride With sodium hydroxide; water; ammonium chloride at 0 - 30℃; for 4h; Stage #2: With hydrogenchloride; water pH=2 - 3; Product distribution / selectivity; | |
| Stage #1: 1,1-cyclohexanediacetic acid anhydride With ammonia; water In isopropyl alcohol at 5℃; for 1h; Stage #2: With hydrogenchloride; water In isopropyl alcohol at 15 - 20℃; for 15h; pH=2 - 3; Product distribution / selectivity; |
- 4355-11-7
1,1-cyclohexanediacetic acid
- 99189-60-3
[1-(2-amino-2-oxoethyl)cyclohexyl]acetic acid
| Conditions | Yield |
|---|---|
| Multi-step reaction with 2 steps 1.1: acetic anhydride / 2 h / 130 °C 2.1: ammonia / benzene / 5 h / 25 - 105 °C 2.2: 1.5 h / 55 °C / pH 4 View Scheme | |
| Multi-step reaction with 2 steps 1: acetic anhydride / 0.5 h / 110 °C 2: ammonium hydroxide / 1 h View Scheme |
- 99189-60-3
[1-(2-amino-2-oxoethyl)cyclohexyl]acetic acid
- 64744-50-9
gabapentin-lactam
| Conditions | Yield |
|---|---|
| Stage #1: [1-(2-amino-2-oxoethyl)cyclohexyl]acetic acid With sodium hydroxide; sodium hypochlorite In water at 0 - 40℃; for 3.5h; Stage #2: With hydrogenchloride In water at 100 - 105℃; for 3h; pH=8.2 - 8.8; Product distribution / selectivity; Heating / reflux; | 100% |
| Stage #1: [1-(2-amino-2-oxoethyl)cyclohexyl]acetic acid With sodium hydroxide; sodium hypochlorite In water at 0 - 50℃; for 3h; Stage #2: With hydrogenchloride In water at 100 - 105℃; for 3h; pH=11 - 12; Product distribution / selectivity; | 93.8% |
| Stage #1: [1-(2-amino-2-oxoethyl)cyclohexyl]acetic acid With sodium hydroxide In water at 20 - 30℃; for 0.5h; Stage #2: With sode de l'acide trichloroisocyanurique In water at 0 - 20℃; for 5h; Stage #3: In water; toluene at 80℃; for 8h; Reagent/catalyst; | 85% |
| Multi-step reaction with 2 steps 1.1: trichloroisocyanuric acid / methanol / 1.75 h / 20 - 25 °C 2.1: sodium hydroxide / water / 4 h / 0 - 20 °C 2.2: 8 h / 80 °C View Scheme |
- 99189-60-3
[1-(2-amino-2-oxoethyl)cyclohexyl]acetic acid
| Conditions | Yield |
|---|---|
| With trichloroisocyanuric acid In methanol at 20 - 25℃; for 1.75h; | 100% |
- 99189-60-3
[1-(2-amino-2-oxoethyl)cyclohexyl]acetic acid
- 63562-00-5
1-(aminomethyl)-1-cyclohexaneacetic acid sodium salt
| Conditions | Yield |
|---|---|
| With sodium hypobromide; sodium hydroxide In water at 40 - 55℃; Reagent/catalyst; Temperature; Hofmann Rearrangement; Flow reactor; | 91.98% |
| With sodium hydroxide; sodium hypobromide In water at 0 - 10℃; for 2 - 3h; Product distribution / selectivity; Hofmann Rearrangement; | 67% |
| With sodium hydroxide; sodium hypochlorite In water at 0 - 10℃; for 2 - 3h; Product distribution / selectivity; Hofmann Rearrangement; | 65% |
- 99189-60-3
[1-(2-amino-2-oxoethyl)cyclohexyl]acetic acid
| Conditions | Yield |
|---|---|
| Stage #1: [1-(2-amino-2-oxoethyl)cyclohexyl]acetic acid With sodium hydroxide; sodium hypochlorite In water at -5 - 25℃; for 9h; Stage #2: With hydrogenchloride In water; butan-1-ol pH=1.5; | 75% |
| Stage #1: [1-(2-amino-2-oxoethyl)cyclohexyl]acetic acid With sodium hydroxide; bromine In water at -8 - 40℃; for 2h; Stage #2: With hydrogenchloride; water for 4h; pH=2; | |
| Multi-step reaction with 2 steps 1.1: sodium hydroxide / water / 0.5 h / 20 - 30 °C 1.2: 5 h / 0 - 20 °C 1.3: 8 h / 80 °C 2.1: hydrogenchloride; water / 10 h / 100 °C View Scheme | |
| Multi-step reaction with 3 steps 1.1: trichloroisocyanuric acid / methanol / 1.75 h / 20 - 25 °C 2.1: sodium hydroxide / water / 4 h / 0 - 20 °C 2.2: 8 h / 80 °C 3.1: hydrogenchloride; water / 10 h / 100 °C View Scheme | |
| Stage #1: [1-(2-amino-2-oxoethyl)cyclohexyl]acetic acid With sodium hypochlorite; sodium hydroxide In water; benzene at 100℃; Stage #2: at 95℃; for 3h; Temperature; |
- 99189-60-3
[1-(2-amino-2-oxoethyl)cyclohexyl]acetic acid
| Conditions | Yield |
|---|---|
| Stage #1: [1-(2-amino-2-oxoethyl)cyclohexyl]acetic acid With sodium hydroxide; sodium hypochlorite In water at -5 - 25℃; for 9h; Stage #2: With sulfuric acid In water; butan-1-ol pH=1.5; | 73.8% |
- 99189-60-3
[1-(2-amino-2-oxoethyl)cyclohexyl]acetic acid
- 60142-96-3
H-Gpn-OH
| Conditions | Yield |
|---|---|
| With sodium carbonate In benzyl alcohol pH=7 - 7.5; Product distribution / selectivity; | 68.6% |
| With sodium hydroxide; sodium hypochlorite In water at -10 - 20℃; for 8h; Hofmann Rearrangement; | |
| Stage #1: [1-(2-amino-2-oxoethyl)cyclohexyl]acetic acid With sodium hypochlorite; sodium hydroxide In water at 40℃; Hofmann Rearrangement; Stage #2: With sodium metabisulfite In water Product distribution / selectivity; |
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Chemistry
Empirical Formula: C10H17NO3
Molecular Weight: 199.2469 g/mol
EINECS: 449-430-4
Index of Refraction: 1.497
Density: 1.135 g/cm3
Flash Point: 222.1 °C
Melting point: 141-146 °C(lit.)
Appearance: White powder
Enthalpy of Vaporization: 76.88 kJ/mol
Boiling Point: 443.6 °C at 760 mmHg
Vapour Pressure: 4.14E-09 mmHg at 25 °C
Structure of 1,1-Cyclohexanediacetic acid mono amide (CAS NO.99189-60-3):
Product Category of 1,1-Cyclohexanediacetic acid mono amide (CAS NO.99189-60-3): Organic acids
Safety Profile
Safety Description of 1,1-Cyclohexanediacetic acid mono amide (CAS NO.99189-60-3): S24/25
S24/25:Avoid contact with skin and eyes.
Specification
1,1-Cyclohexanediacetic acid mono amide , its cas register number is 99189-60-3. It also can be called 3,3-Pentamethyleneglutaramic acid .