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CAS No.: | 934-32-7 |
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Name: | 2-Aminobenzimidazole |
Article Data: | 94 |
Molecular Structure: | |
Formula: | C7H7N3 |
Molecular Weight: | 133.153 |
Synonyms: | Benzimidazole,2-amino- (6CI,7CI,8CI);1H-Benzimidazol-2-ylamine;2-Amino-1H-benzimidazole;2-Benzimidazolamine;2-Benzimidazolylamine;2-Iminobenzimidazoline;NSC 27793;NSC 7628; |
EINECS: | 213-280-6 |
Density: | 1.367 g/cm3 |
Melting Point: | 226-230 °C(lit.) |
Boiling Point: | 368.9 °C at 760 mmHg |
Flash Point: | 204.6 °C |
Solubility: | Soluble in water (Slightly). |
Appearance: | light yellow to cream or beige powder or flakes |
Hazard Symbols: | Xn |
Risk Codes: | 22-36/37/38-43 |
Safety: | 26-36/37/39-22 |
PSA: | 54.70000 |
LogP: | 1.72630 |
Conditions | Yield |
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With sodium tetrahydroborate; tin bis(1,2-benzenethiolate) In tetrahydrofuran; phosphate buffer at 10℃; for 0.5h; pH=10; Reduction; | 100% |
With dibutyltin In benzene at 40℃; for 2h; other reagents; | 98% |
With acetic acid In dichloromethane at 20℃; for 2h; Irradiation; |
Conditions | Yield |
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In methanol; water at 20 - 60℃; Inert atmosphere; | 97% |
In ethanol; water at 70℃; for 1h; | 90% |
In methanol; water at 50℃; for 1h; | 89% |
Conditions | Yield |
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In isopropyl alcohol at 60℃; | 95% |
formamide
1,2-diamino-benzene
1H-benzimidazol-2-amine
Conditions | Yield |
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With N-sulfonated biguanidine modified silica coated on cobalt ferrite nanoparticle core In ethanol at 20℃; for 0.3h; Green chemistry; | 92% |
Conditions | Yield |
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In methanol; water at 20℃; for 24h; | 88% |
In water at 20℃; | 75% |
Conditions | Yield |
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at 700℃; under 0.02 Torr; Gas phase; | A 85% B 86% |
Conditions | Yield |
---|---|
at 700℃; under 0.02 Torr; Gas phase; | A 78% B 85% |
Conditions | Yield |
---|---|
Stage #1: bromocyane; o-phenylenediamine dihydrochloride With sodium hydrogencarbonate In water; acetonitrile at 0 - 20℃; Stage #2: With sodium carbonate In water; acetonitrile | 85% |
Conditions | Yield |
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In N,N-dimethyl-formamide for 4h; Heating; | 82% |
N-tert-butyl-1H-benzo[d]imidazol-2-amine
1H-benzimidazol-2-amine
Conditions | Yield |
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With hydrogenchloride In water for 12h; Reflux; | 82% |
1. | mma-sat 710 µmol/L | ENMUDM Environmental Mutagenesis. 3 (1981),11. | ||
2. | mmo-sat 100 µg/plate | MUREAV Mutation Research. 15 (1972),273. | ||
3. | orl-rat TDLo:426 mg/kg (8-15D preg):TER | THERAP Therapie. 31 (1976),505. | ||
4. | orl-rat LDLo:500 mg/kg | NCNSA6 National Academy of Sciences, National Research Council, Chemical-Biological Coordination Center, Review. 5 (1953),22. | ||
5. | orl-mus LD40:600 mg/kg | JACSAT Journal of the American Chemical Society. 67 (1945),905. | ||
6. | ipr-mus LD50:100 mg/kg | NTIS** National Technical Information Service. (Springfield, VA 22161) (Formerly U.S. Clearinghouse for Scientific and Technical Information) AD277-689 . | ||
7. | ivn-mus LD50:126 mg/kg | 29QHAQ Principles of Medicinal Chemistry Foye, W.O., eds.,Philadelphia, PA.: Lea and Febiger,1974,246. |