Products Categories
| CAS No.: | 797-63-7 |
|---|---|
| Name: | Levonorgestrel |
| Article Data: | 27 |
| Molecular Structure: | |
|
|
|
| Formula: | C21H28O2 |
| Molecular Weight: | 312.452 |
| Synonyms: | 18,19-Dinor-17a-pregn-4-en-20-yn-3-one,13-ethyl-17-hydroxy- (7CI,8CI);(-)-Norgestrel;13-Ethyl-17-hydroxy-18,19-dinor-17a-pregn-4-en-20-yn-3-one;13-Ethyl-17a-ethynyl-17-hydroxygon-4-en-3-one;17a-Ethynyl-13-ethyl-19-nortestosterone;17a-Ethynyl-13b-ethyl-3-oxo-4-estren-17b-ol;17a-Ethynyl-18-homo-19-nortestosterone;18-Methylnorethindrone;19-Nortestosterone, 17-ethynyl-18-methyl-;D-(-)-Norgestrel;Dexnorgestrel;Femilis;Femilis Slim;Follistrel;Jadelle;Lng-IUS;Microlut;Microval;Mirena;Norgestrelem;Norlevo;Norplant;Norplant 2;Postinor 2;Wy 5104;d-(17a)-17-Hydroxy-13-ethyl-18,19-dinorpregn-4-en-20-yn-3-one;18,19-Dinorpregn-4-en-20-yn-3-one,13-ethyl-17-hydroxy-, (17a)-; |
| EINECS: | 212-349-8 |
| Density: | 1.13 g/cm3 |
| Melting Point: | 206 °C |
| Boiling Point: | 459.1 °C at 760 mmHg |
| Flash Point: | 195.4 °C |
| Solubility: | 10mg/L(temperature not stated) |
| Appearance: | white solid |
| Hazard Symbols: |
 Xn
|
| Risk Codes: | 20/21/22-40 |
| Safety: | 22-36 |
| PSA: | 37.30000 |
| LogP: | 3.88260 |
13β-ethyl-3-methoxy-17α-ethynyl-gona-2,5(10)-dien-17β-ol
| Conditions | Yield |
|---|---|
| With sulfuric acid; water In tetrahydrofuran at 65 - 68℃; | 84.6% |
| With hydrogenchloride; water In methanol at 55 - 60℃; for 3h; | 84.6% |
| With hydrogenchloride In methanol; water; ethyl acetate; benzene | |
| With sulfuric acid In tetrahydrofuran at 65 - 68℃; Product distribution / selectivity; | |
| With hydrogenchloride In methanol; water; ethyl acetate; benzene |
| Conditions | Yield |
|---|---|
| (i) Li, H2NCH2CH2NH2, THF, (ii) aq. HCl, MeOH; Multistep reaction; | |
| With hydrogenchloride; lithium diisopropyl amide 1.) THF, 2.5 h; 2.) MeOH, 60-70 deg C, 3 h; Yield given. Multistep reaction; | |
| With hydrogenchloride; lithium 1.) ethylenediamine, 1 h; 2.) THF, r.t., 2 h; 3.) MeOH, 45-50 degC, 45 min; Yield given. Multistep reaction; |
| Conditions | Yield |
|---|---|
| With hydrogenchloride; cerium(III) chloride 1) THF, room temperature, 1 h, 2) MeOH, 0 deg C, 0.5 h; Yield given. Multistep reaction; |
3-methoxy-13β-ethyl-gona-3,5-dien-17-one
acetylenemagnesium bromide
levonorgestrel
| Conditions | Yield |
|---|---|
| With hydrogenchloride; cerium(III) chloride 1) THF, room temperature, 1 h, 2) MeOH, 0 deg C, 0.5 h; Yield given. Multistep reaction; |
D-13β-ethyl-17β-hydroxy-3-methoxy-gona-2,5(10)-diene
levonorgestrel
| Conditions | Yield |
|---|---|
| Multi-step reaction with 2 steps 1: 84 percent / mol. sieve, 2-butanone, aluminium isopropylate / benzene / 12 h / Heating 2: 1.) LDA; 2.) 6 percent HCl / 1.) THF, 2.5 h; 2.) MeOH, 60-70 deg C, 3 h View Scheme | |
| Multi-step reaction with 2 steps 1: Al(OiPr)3 / butan-2-one; benzene / Heating 2: (i) Li, H2NCH2CH2NH2, THF, (ii) aq. HCl, MeOH View Scheme | |
| Multi-step reaction with 3 steps 1: water; cyclohexanone; toluene 2: tetrahydrofuran; water 3: hydrogenchloride / methanol; water; ethyl acetate; benzene View Scheme | |
| Multi-step reaction with 3 steps 2: tetrahydrofuran; water 3: hydrogenchloride / methanol; water; ethyl acetate; benzene View Scheme |
2-Trimethylsilyl-1-(4-methoxy-2-methylphenyl)-2-propen-1-on
levonorgestrel
| Conditions | Yield |
|---|---|
| Multi-step reaction with 4 steps 1: 1.) 80 percent NaH; 2.) 10 percent H2SO4 / 1.) DME, parrafin oil, 3.5 h, reflux; Et2O, -20 deg C, 30 min; 2.) MeOH, 24 h 3: 84 percent / mol. sieve, 2-butanone, aluminium isopropylate / benzene / 12 h / Heating 4: 1.) LDA; 2.) 6 percent HCl / 1.) THF, 2.5 h; 2.) MeOH, 60-70 deg C, 3 h View Scheme |
levonorgestrel
| Conditions | Yield |
|---|---|
| Multi-step reaction with 4 steps 1: 1.) 80 percent NaH; 2.) 10 percent H2SO4 / 1.) DME, parrafin oil, 3.5 h, reflux; Et2O, -20 deg C, 30 min; 2.) MeOH, 24 h 3: 84 percent / mol. sieve, 2-butanone, aluminium isopropylate / benzene / 12 h / Heating 4: 1.) LDA; 2.) 6 percent HCl / 1.) THF, 2.5 h; 2.) MeOH, 60-70 deg C, 3 h View Scheme |
13-Ethyl-3-methoxy-6,7:8,9-disecogona-1,3,5(10),7-tetraen-9,17-dion
levonorgestrel
| Conditions | Yield |
|---|---|
| Multi-step reaction with 3 steps 2: 84 percent / mol. sieve, 2-butanone, aluminium isopropylate / benzene / 12 h / Heating 3: 1.) LDA; 2.) 6 percent HCl / 1.) THF, 2.5 h; 2.) MeOH, 60-70 deg C, 3 h View Scheme |
13β-Aethyl-3-methoxy-gonapentaen-(1.3.5(10).8.14)-ol-(17β)-acetat
levonorgestrel
| Conditions | Yield |
|---|---|
| Multi-step reaction with 5 steps 1: H2 / Pd-CaCO3 / benzene; tetrahydrofuran 2: KOH / methanol 3: (i) LiNH2, liq. NH3, PhNH2, THF, (ii) AcOH, EtOH 4: Al(OiPr)3 / butan-2-one; benzene / Heating 5: (i) Li, H2NCH2CH2NH2, THF, (ii) aq. HCl, MeOH View Scheme |
| Conditions | Yield |
|---|---|
| Multi-step reaction with 3 steps 1: (i) LiNH2, liq. NH3, PhNH2, THF, (ii) AcOH, EtOH 2: Al(OiPr)3 / butan-2-one; benzene / Heating 3: (i) Li, H2NCH2CH2NH2, THF, (ii) aq. HCl, MeOH View Scheme | |
| Multi-step reaction with 5 steps 1: ammonium chloride; ammonia / tetrahydrofuran; water; aniline 2: ammonia; lithium / tetrahydrofuran; ethanol; water 4: tetrahydrofuran; water 5: hydrogenchloride / methanol; water; ethyl acetate; benzene View Scheme | |
| Multi-step reaction with 5 steps 1: ammonium chloride; ammonia / tetrahydrofuran; water; aniline 2: ammonia; lithium / tetrahydrofuran; ethanol; water 3: water; cyclohexanone; toluene 4: tetrahydrofuran; water 5: hydrogenchloride / methanol; water; ethyl acetate; benzene View Scheme |
What can I do for you?
Get Best Price
The Levonorgestrel, with the CAS registry number 797-63-7,is also known as D(-)-13beta-Ethyl-17alpha-ethynyl-17beta-hydroxygon-4-en-3-one. It belongs to the product categories of Pharmaceuticals;Steroid and Hormone. This chemical's molecular formula is C21H28O2 and molecular weight is 312.45.Its EINECS number is 212-349-8. What's more,Its systematic name is Levonorgestrel. It is a White Solid which is an emergency contraceptive. Levonorgestrel is safe, tolerated and effective in emergency contraception in woman.It is a synthetic progestational hormone with actions similar to those of and Progesterone about twice as potent as its racemic or (+-)-isomer (NORGESTREL). It is used for contraception, control of menstrual disorders, and treatment of endometriosis.
Physical properties about Levonorgestrel are:
(1)ACD/LogP: 3.92; (2)# of Rule of 5 Violations: 0; (3)ACD/LogD (pH 5.5): 3.92; (4)ACD/LogD (pH 7.4): 3.92; (5)ACD/BCF (pH 5.5): 557.22; (6)ACD/BCF (pH 7.4): 557.22; (7)ACD/KOC (pH 5.5): 3215.19; (8)ACD/KOC (pH 7.4): 3215.18; (9)#H bond acceptors: 2; (10)#H bond donors: 1; (11)#Freely Rotating Bonds: 2; (12)Index of Refraction: 1.571; (13)Molar Refractivity: 90.18 cm3; (14)Molar Volume: 274.3 cm3; (15)Polarizability: 35.75×10-24 cm3; (16)Surface Tension: 48.3 dyne/cm; (17)Enthalpy of Vaporization: 82.99 kJ/mol; (18)Vapour Pressure: 2.32E-10 mmHg at 25°C; (19)Rotatable Bond Count: 2; (20)Tautomer Count: 8; (21)Exact Mass: 312.20893; (22)MonoIsotopic Mass: 312.20893; (23)Topological Polar Surface Area: 37.3; (24)Heavy Atom Count: 23; (25)Complexity: 609.
People can use the following data to convert to the molecule structure:
(1)SMILES:O=C4\C=C3/[C@@H]([C@H]2CC[C@]1([C@@H](CC[C@]1(C#C)O)[C@@H]2CC3)CC)CC4
(2) InChI:InChI=1/C21H28O2/c1-3-20-11-9-17-16-8-6-15(22)13-14(16)5-7-18(17)19(20)10-12-21(20,23)4-2/h2,13,16-19,23H,3,5-12H2,1H3/t16-,17+,18+,19-,20-,21-/m0/s1
(3)InChIKey:WWYNJERNGUHSAO-XUDSTZEEBP
Safety information of Levonorgestrel:
When you are using this chemical, please be cautious about it as the following:
It is not only harmful by inhalation, in contact with skin and if swallowed, but also has limited evidence of a carcinogenic effect. So people should not breathe dust. If you want to contact this product, you must wear suitable protective clothing.
Uses of Levonorgestrel:
Levonorgestrel is used in monophasic and triphasic formulations of combined oral contraceptive pills at low doses. It is also used in emergency contraceptive pills (ECPs), both in a combined Yuzpe regimen which includes estrogen, and as a levonorgestrel-only method. This drug has many side effects, including nausea, vomiting, stomach pain, dizziness, breast tenderness, tiredness and weakness, headache, menstrual changes, and diarrhea. It is also a pregnancy hormone drug.
