60-34-4

Community Right-To-Know List. EPA Extremely Hazardous Substances List. Reported in EPA TSCA Inventory. EPA Genetic Toxicology Program.

OSHA PEL: CL 0.2 ppm (skin)
ACGIH TLV: TWA 0.01 ppm (skin); Suspected Human Carcinogen
NIOSH REL: CL 0.08 mg/m³/2H
DOT Classification:  6.1; Label: Poison, Flammable Liquid, Corrosive

For occupational chemical analysis use NIOSH: Monomethylhydrazine S149.

The Methyl hydrazine, with the cas registry number 60-34-4, is a kind of colorless liquid with an ammonia-like odour. Being a kind of flammable chemical, this is soluble in ethanol and other solvents and is incompatible with strong oxidizing agents, copper, iron and their alloys. And its product categories are including Aliphatics; Pharmaceutical Intermediate; Hydrazines; Nitrogen Compounds; Organic Building Blocks. When store it, keep it in a dry, cool, and well-ventilated place. Its preparation method is to react methylamine and chloramines (NH₂Cl) to get products: CH₃NH₂ + NH₂Cl → CH₃NHNH₂ + HCl.

The characteristics of this chemical are as follows: (1)ACD/LogP: -1.05; (2)# of Rule of 5 Violations: 0; (3)ACD/LogD (pH 5.5): -3.97; (4)ACD/LogD (pH 7.4): -2.55; (5)ACD/BCF (pH 5.5): 1; (6)ACD/BCF (pH 7.4): 1; (7)ACD/KOC (pH 5.5): 1; (8)ACD/KOC (pH 7.4): 1; (9)#H bond acceptors: 2; (10)#H bond donors: 3; (11)#Freely Rotating Bonds: 1; (12)Polar Surface Area: 6.48; (13)Index of Refraction: 1.395; (14)Molar Refractivity: 13.81 cm³; (15)Molar Volume: 57.5 cm³; (16)Polarizability: 5.47 ×10^-24 cm³; (17)Surface Tension: 25.2 dyne/cm; (18)Density: 0.8 g/cm³; (19)Flash Point: 21.1 °C; (20)Enthalpy of Vaporization: 36.12 kJ/mol; (21)Boiling Point: 87.5 °C at 760 mmHg; (22)Vapour Pressure: 63.6 mmHg at 25°C; (23)Exact Mass: 46.053098; (24)MonoIsotopic Mass: 46.053098; (25)Topological Polar Surface Area: 38; (26)Heavy Atom Count: 3; (27)Formal Charge: 0; (28)Complexity: 2.8.

Use of this chemical: Methyl hydrazine could react with pyrazine-2-carboxylic acid methyl ester to produce pyrazine-2-carboxylic acid-(N'-methyl-hydrazide), with the following condition: solvent: ethanol; yield: 81.1 %; other condition: Heating.

As to its usage, it is widely applied in many ways. It could be used as the intermediate of herbicide Pyrazosulfuron-ethyl, acaricide Fenpyroximate and Tebufenpyrad; It could also be used in organic synthesis.
 
People should be careful while dealing with this chemical. For one thing, it is very toxic which may at very low levels cause damage to health. If by inhalation, in contact with skin or if swallowed, it will be very dangerous. And with limited evidence of a carcinogenic effectits, it may cause cancer. For another thing, it is dangerous for the environment which may present an immediate or delayed danger to one or more components of the environment. Being toxic to aquatic organisms, it may cause long-term adverse effects in the aquatic environment. In addition, it is highly flammable chemical, and it may catch fire in contact with air, only needing brief contact with an ignition source with a very low flash point.
 
Therefore, people should take the following instructions. Wear suitable protective clothing, gloves and eye/face protection, and remember to avoid contacting with skin and eyes. If in case of contact with eyes, rinse immediately with plenty of water and seek medical advice; If in case of accident or if you feel unwell, seek medical advice immediately (show the label where possible). And after contacting with skin, wash immediately with plenty of ... (to be specified by the manufacturer). Besides , when keeping this chemical, please be sure that this material and its container must be disposed of as hazardous waste, keeping away from sources of ignition - No smoking.   

You could obtain the molecular structure by converting the following datas:
(1)Canonical SMILES: CNN
(2)InChI: InChI=1S/CH6N2/c1-3-2/h3H,2H2,1H3
(3)InChIKey: HDZGCSFEDULWCS-UHFFFAOYSA-N

Below are the toxicity information of this chemical:

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Effect	Source
dog	LC50	inhalation	96ppm/1H (96ppm)		American Industrial Hygiene Association Journal. Vol. 31, Pg. 667, 1970.
dog	LD50	intravenous	12mg/kg (12mg/kg)	BLOOD: METHEMOGLOBINEMIA-CARBOXYHEMOGLOBIN	Proceedings of the Society for Experimental Biology and Medicine. Vol. 131, Pg. 226, 1969.
guinea pig	LC50	inhalation	270mg/m3/4H (270mg/m3)	BRAIN AND COVERINGS: OTHER DEGENERATIVE CHANGES LIVER: LIVER FUNCTION TESTS IMPAIRED LUNGS, THORAX, OR RESPIRATION: ACUTE PULMONARY EDEMA	"Spravochnik po Toksikologii i Gigienicheskim Normativam Vol. -, Pg. 163, 1999.
guinea pig	LD50	skin	48mg/kg (48mg/kg)	BLOOD: METHEMOGLOBINEMIA-CARBOXYHEMOGLOBIN	Proceedings of the Society for Experimental Biology and Medicine. Vol. 131, Pg. 226, 1969.
hamster	LC50	inhalation	143ppm/4H (143ppm)	BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD	AMA Archives of Industrial Health. Vol. 12, Pg. 609, 1955.
hamster	LD50	intraperitoneal	21mg/kg (21mg/kg)		Clinical Toxicology. Vol. 4, Pg. 435, 1971.
hamster	LD50	oral	22mg/kg (22mg/kg)		Clinical Toxicology. Vol. 4, Pg. 435, 1971.
hamster	LD50	skin	239mg/kg (239mg/kg)		Clinical Toxicology. Vol. 4, Pg. 435, 1971.
monkey	LC50	inhalation	82ppm/1H (82ppm)	SENSE ORGANS AND SPECIAL SENSES: CONJUNCTIVE IRRITATION: EYE GASTROINTESTINAL: NAUSEA OR VOMITING BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD	American Industrial Hygiene Association Journal. Vol. 31, Pg. 667, 1970.
mouse	LC50	inhalation	56ppm/4H (56ppm)	SENSE ORGANS AND SPECIAL SENSES: OTHER: EYE BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD LUNGS, THORAX, OR RESPIRATION: DYSPNEA	AMA Archives of Industrial Health. Vol. 12, Pg. 609, 1955.
mouse	LD50	intraperitoneal	15mg/kg (15mg/kg)	SENSE ORGANS AND SPECIAL SENSES: MIOSIS (PUPILLARY CONSTRICTION): EYE SKIN AND APPENDAGES (SKIN): HAIR: OTHER BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD	Proceedings of the Society for Experimental Biology and Medicine. Vol. 124, Pg. 172, 1967.
mouse	LD50	intravenous	33200ug/kg (33.2mg/kg)		Medycyna Pracy. Industrial Medicine. Vol. 24, Pg. 71, 1973.
mouse	LD50	oral	29mg/kg (29mg/kg)	BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD BEHAVIORAL: EXCITEMENT	National Technical Information Service. Vol. AD-A125-539,
mouse	LD50	subcutaneous	25mg/kg (25mg/kg)		British Journal of Cancer. Vol. 30, Pg. 429, 1974.
rabbit	LD50	intravenous	12mg/kg (12mg/kg)	BLOOD: METHEMOGLOBINEMIA-CARBOXYHEMOGLOBIN	Proceedings of the Society for Experimental Biology and Medicine. Vol. 131, Pg. 226, 1969.
rabbit	LD50	skin	95mg/kg (95mg/kg)	BLOOD: METHEMOGLOBINEMIA-CARBOXYHEMOGLOBIN	Proceedings of the Society for Experimental Biology and Medicine. Vol. 131, Pg. 226, 1969.
rat	LC50	inhalation	34ppm/4H (34ppm)		Aerospace Medical Research Laboratory Report. Vol. TR-67-137, Pg. 1967,
rat	LD50	intraperitoneal	21mg/kg (21mg/kg)		Clinical Toxicology. Vol. 4, Pg. 435, 1971.
rat	LD50	intravenous	17mg/kg (17mg/kg)		Clinical Toxicology. Vol. 4, Pg. 435, 1971.
rat	LD50	oral	32mg/kg (32mg/kg)	BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD	U.S. Army Chemical Warfare Laboratories. Vol. CWL,
rat	LD50	skin	183mg/kg (183mg/kg)		Clinical Toxicology. Vol. 4, Pg. 435, 1971.
rat	LD50	subcutaneous	35mg/kg (35mg/kg)		British Journal of Cancer. Vol. 30, Pg. 429, 1974.