Name: 2-methylpropane-1,2-diol
SKU: 558-43-0

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Basic Information

Molecular Structure:
CAS No.:	558-43-0
Name:	2-methylpropane-1,2-diol
Article Data:	77

Formula:	C4H10 O2
Molecular Weight:	90.1222
Synonyms:	1,2-Dihydroxy-2-methylpropane;1,2-Dihydroxyisobutane; 2-Hydroxy-2-methylpropanol; 2-Methyl-1,2-propanediol;2-Methyl-2-hydroxypropanol; Isobutene glycol; Isobutylene glycol
Density:	1.005g/cm³
Melting Point:	0.07°C (estimate)
Boiling Point:	176°Cat760mmHg
Flash Point:	73.7°C
PSA:	40.46000
LogP:	-0.25040

Synthetic route

Conditions	Yield
With hydrogen; 20% Pd(OH)2/C In methanol at 20℃; under 1551.49 Torr; for 1.16667h;	99%

Conditions	Yield
With [carbonylchlorohydrido{bis[2-(diphenylphosphinomethyl)ethyl]amino}ethylamino] ruthenium(II); potassium tert-butylate; hydrogen In tetrahydrofuran at 140℃; for 12h; Autoclave;	A > 99 %Chromat. B 97%
With [bis({2‐[bis(propan‐2‐yl)phosphanyl]ethyl})amine](bromo)(carbonyl)(hydride)iron(II); potassium tert-butylate; isopropyl alcohol In tetrahydrofuran at 140℃; for 12h; Inert atmosphere; Schlenk technique; Green chemistry;	A 86 %Chromat. B 92%
With potassium phosphate; C62H63N5OPRu(1+)*Cl(1-); hydrogen In tetrahydrofuran at 140℃; under 38002.6 Torr; for 24h; Glovebox; Autoclave;	A 95 %Chromat. B 99 %Chromat.

B: 67505-10-6
<<2α(R),3β>-1S,2S>-1-(2-methyl-3-phenyloxiranyl)-1,2-propanediol

Conditions	Yield
With titanium(IV) isopropylate; 2-hydroperoxy-2-methyl-1-propanol; 4 A molecular sieve at 20℃; for 1h; other reagents: 2,3-dimethyl-3-hydroperoxy-2-butanol, 2-hydroperoxy-2-phenyl-1-ethanol, m-chloroperoxybenzoic acid, NaHCO3, dimethyldioxirane;	A n/a B 91%

Conditions	Yield
With lithium aluminium tetrahydride In tetrahydrofuran at 0 - 20℃; for 16h; Inert atmosphere;	86%
With barium copper chromite at 200℃; under 128714 Torr; Hydrogenation;
With copper chromite at 100 - 125℃; under 257428 Torr; Hydrogenation;

Conditions	Yield
With lithium aluminium tetrahydride In tetrahydrofuran at 0 - 20℃; for 1h;	82.6%
Stage #1: methyl 2-hydroxy-2-methylpropionate With lithium aluminium tetrahydride In tetrahydrofuran at 20℃; Stage #2: With water; sodium hydroxide In tetrahydrofuran	68%
With potassium tert-butylate; hydrogen; [tris(μ-chloro)bis((triphos)ruthenium(II))] chloride In methanol at 100℃; under 30003 Torr; for 13h; Inert atmosphere; Autoclave;	90.4 %Chromat.
With lithium aluminium tetrahydride In tetrahydrofuran at 0 - 20℃; for 12.3333h;

: 67872-66-6
α-methyl-α-((1-tert-butoxy-2-methyl-2,3-epoxypropyl)oxy)-β-propiolactone

Conditions	Yield
With lithium aluminium tetrahydride In diethyl ether for 9h; mol ratio 1:3;	A 10.7% B 33.4% C 55.9%

Conditions	Yield
In tetrahydrofuran at 0℃;	53%

Conditions	Yield
With sodium perchlorate; water at 35℃; Rate constant; ionic strength: 2.0; kinetic isotope effect;
With sulfuric acid at 90℃;
With sulfuric acid; water
With phosphoric acid In water at 20℃;
With water-d2; hydrogen chloride