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CAS No.: | 52-89-1 |
---|---|
Name: | L-Cysteine hydrochloride anhydrous |
Article Data: | 8 |
Molecular Structure: | |
Formula: | C3H8ClNO2S |
Molecular Weight: | 157.621 |
Synonyms: | (R)-Cysteine hydrochloride;Cysteine monohydrochloride;3-Mercaptoalanine hydrochloride;Cysteine chlorohydrate;(2R)-2-amino-3-sulfanyl-propanoic acid hydrochloride;Cysteine, L-, monohydrochloride;L-(+ )-Cysteine hydrochloride;L-Cysteine HCl Anhydrous;L-Cysteine HCl Anhy;(R)-Cysteine-hydrochloride;L-(+)-Cysteine hydrochloride;L-2-Amino-3-mercaptopropanoic acid monohydrochloride;H-Cys-OH.HCl;L- Cysteine Hydrochloride Anhydrous;L-Cysteine hydrochloride monohydrate;L-Cysteine HCL anhydrouse; |
EINECS: | 200-157-7 |
Melting Point: | 180 ºC |
Boiling Point: | 293.9 ºC at 760 mmHg |
Flash Point: | 131.5 ºC |
Solubility: | soluble in water |
Appearance: | white solid |
Hazard Symbols: | Xi |
Risk Codes: | 36/37/38 |
Safety: | 26-36 |
PSA: | 102.12000 |
LogP: | 0.83040 |
(3R)-2-methyl-4,5-dihydrothiazole-4-carboxylic acid methyl ester
l-cysteine hydrochloride
Conditions | Yield |
---|---|
With hydrogenchloride; water for 24h; Inert atmosphere; Reflux; | 94% |
N-(tert-butoxycarbonyl)-S-(N-methylcarbamoyl)cysteine methyl ester
A
l-cysteine hydrochloride
B
S-(N-methylcarbamoyl)cysteine hydrochloride
Conditions | Yield |
---|---|
With hydrogenchloride for 168h; | A 15% B 83% |
S-(diphenyl-4-pyridylmethyl)-L-cysteine
A
diphenyl(pyridin-4-yl)methanol
B
l-cysteine hydrochloride
Conditions | Yield |
---|---|
With mercury(II) diacetate In water; acetic acid for 0.25h; Product distribution; other reagent (zinc dust, 80percent acetic acid, 15 min); |
cycloforskamide
B
l-cysteine hydrochloride
C
L-valine hydrochloride
D
L-isoleucine hydrochloride
E
L-threonine methyl ester hydrochloride
Conditions | Yield |
---|---|
With hydrogenchloride; water at 110℃; for 24h; |
l-cysteine hydrochloride
benzaldehyde
(4R)-2-phenyl-1,3-thiazolidine-4-carboxylic acid
Conditions | Yield |
---|---|
Stage #1: l-cysteine hydrochloride With sodium hydroxide In water Stage #2: benzaldehyde In ethanol; water at 20℃; for 3h; | 100% |
With potassium acetate In methanol; water at 0 - 25℃; for 6h; | 98% |
Stage #1: l-cysteine hydrochloride With potassium carbonate In water Stage #2: benzaldehyde In methanol; water at 25℃; for 3h; | 98% |
(9H-fluoren-9-yl)methyl 4-methylbenzenesulfonaye
l-cysteine hydrochloride
(R)-9H-fluorenyl-9-methyl-L-cysteine
Conditions | Yield |
---|---|
With N-ethyl-N,N-diisopropylamine In N,N-dimethyl-formamide | 100% |
formaldehyd
l-cysteine hydrochloride
(R)-thiazolidine-4-carboxylic acid hydrochloride
Conditions | Yield |
---|---|
at 20℃; for 1h; Solid phase reaction; cyclocondensation; | 100% |
Stage #1: formaldehyd; l-cysteine hydrochloride With sodium hydroxide In water at 20℃; for 24h; Stage #2: With pyridine In ethanol; water at 0℃; | 80% |
l-cysteine hydrochloride
benzonitrile
(4R)-2-phenyl-4,5-dihydro-1,3-thiazole-4-carboxylic acid
Conditions | Yield |
---|---|
With sodium hydrogencarbonate In methanol at 70℃; pH=7; aq. phosphate buffer; Inert atmosphere; | 99% |
With sodium hydrogencarbonate In methanol; aq. phosphate buffer for 72h; pH=6; Reflux; | 73% |
With piperidine; sodium hydrogencarbonate In ethanol |
Methoxycarbonylsulfenyl chloride
l-cysteine hydrochloride
Conditions | Yield |
---|---|
With hydrogenchloride In methanol at 0℃; for 1h; | 99% |
salicylonitrile
l-cysteine hydrochloride
(R)-2-(2-hydroxyphenyl)-4,5-dihydro-1,3-thiazole-4-carboxylic acid
Conditions | Yield |
---|---|
With sodium hydrogencarbonate In methanol; aq. phosphate buffer for 72h; pH=6; Reflux; | 99% |
Stage #1: salicylonitrile; l-cysteine hydrochloride With sodium hydrogencarbonate In ethanol for 0.5h; Heating; Stage #2: With piperidine In ethanol for 12h; pH=9; Heating; Stage #3: With hydrogenchloride In ethanol pH=1.5; | 67% |
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Reported in EPA TSCA Inventory.
1. Introduction of L-Cysteine hydrochloride anhydrous
L-Cysteine hydrochloride anhydrous (CAS No. 52-89-1), with the IUPAC Name of (2R)-2-Amino-3-sulfanylpropanoic acid hydrochloride, is one kind of white crystalline powder. And this chemical belongs to the Classification Code which include Drug / Therapeutic Agent; Mutation data. For being stable under normal shipping and handling conditions, this chemical is incompatible with strong oxidizing agents, metals. And the decomposition information are as below: Hydrogen chloride, nitrogen oxides, carbon monoxide, oxides of sulfur, carbon dioxide, nitrogen.
2. Properties of L-Cysteine hydrochloride anhydrous
L-Cysteine hydrochloride anhydrous has the following datas: (1)Melting point: 180°C; (2)H bond acceptors: 3; (3)H bond donors: 3; (4)Freely Rotating Bonds: 4; (5)Polar Surface Area: 54.84 ?2; (6)Flash Point: 131.5 °C; (7)Enthalpy of Vaporization: 58.69 kJ/mol; (8)Boiling Point: 293.9 °C at 760 mmHg; (9)Vapour Pressure: 0.000411 mmHg at 25°C.
3. Structure Descriptors of L-Cysteine hydrochloride anhydrous
You could convert the following datas into the molecular structure:
(1). InChI: InChI=1S/C3H7NO2S.ClH/c4-2(1-7)3(5)6;/h2,7H,1,4H2,(H,5,6);1H/t2-;/m0./s1
(2). InChIKey: InChIKey=IFQSXNOEEPCSLW-DKWTVANSSA-N
(3). Smiles: C([C@H](CS)N)(O)=O.Cl
4. Toxicity of L-Cysteine hydrochloride anhydrous
Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
---|---|---|---|---|---|
mouse | LD50 | intraperitoneal | 1250mg/kg (1250mg/kg) | National Technical Information Service. Vol. AD691-490, | |
mouse | LD50 | intravenous | 771mg/kg (771mg/kg) | Japanese Journal of Antibiotics. Vol. 38, Pg. 137, 1985. | |
mouse | LD50 | unreported | 3gm/kg (3000mg/kg) | British Journal of Cancer. Vol. 6, Pg. 160, 1952. |
6. Use of L-Cysteine hydrochloride anhydrous
L-Cysteine hydrochloride anhydrous can be usde for the treatment of radioactive drug poisoning, heavy metal poisoning, toxic hepatitis, serum sickness, etc.,and also can prevent the liver necrosis.Besides.it is used as perm for fine cosmetics, sunscreen, germinal perfume, raise fa in composition; can be used as food additives, vitamin C to prevent oxidation and discoloration; for the bread to promote the formation of protein and fermentation of grain, out of molds.
7. Production of L-Cysteine hydrochloride anhydrous
L-Cysteine hydrochloride anhydrous can produced by using L-cystine as raw materials and using stannous chloride in hydrochloric acid medium to restore, and then derived from refined crystal.