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| CAS No.: | 41100-52-1 |
|---|---|
| Name: | Memantine HCl |
| Article Data: | 53 |
| Molecular Structure: | |
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| Formula: | C12H21N.HCl |
| Molecular Weight: | 215.766 |
| Synonyms: | Akatinol;Memantine hydrochloride [USAN];Axura;Namenda;Ebixza;Tricyclo(3.3.1.1(3,7))decan-1-amine, 3,5-dimethyl-, hydrochloride;3,5-Dimethyltricyclo(3.3.1.13,7)decan-1-amine hydrochloride;3,5-dimethyladamantan-1-amine hydrochloride;Memantine HCl;1,3-Dimethyl-5-aminoadamantane hydrochloride;Fructus Mume P.E.;3,5-dimethyltricyclo[3.3.1.13,7]decan-1-amine hydrochloride; |
| EINECS: | 255-219-6 |
| Melting Point: | 292 °C |
| Boiling Point: | 239.8 °C at 760 mmHg |
| Flash Point: | 92.3 °C |
| Appearance: | Crystalline solid |
| Safety: | 24/25 |
| PSA: | 26.02000 |
| LogP: | 4.19640 |
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2,2,2-trichloroethyl 3,5-dimethyladamantylcarbamate
- 41100-52-1
memantine hydrochloride
| Conditions | Yield |
|---|---|
| Stage #1: 2,2,2-trichloroethyl 3,5-dimethyladamantylcarbamate With acetic acid; zinc at 20℃; for 2h; Stage #2: With acetyl chloride In methanol at 40℃; for 16h; Heating; | 100% |
- 19982-07-1
1-acetamido-3,5-dimethyladamantane
- 41100-52-1
memantine hydrochloride
| Conditions | Yield |
|---|---|
| Stage #1: 1-acetamido-3,5-dimethyladamantane With sodium hydroxide In diethylene glycol for 6h; Reflux; Stage #2: With water In dichloromethane; diethylene glycol at 20℃; for 0.25h; Stage #3: With hydrogenchloride In ethyl acetate at 0 - 30℃; for 6h; | 99.3% |
| Stage #1: 1-acetamido-3,5-dimethyladamantane With potassium hydroxide; butan-1-ol at 20 - 132℃; for 10.33 - 10.5h; Stage #2: With hydrogenchloride In water at 20 - 25℃; for 0.666667h; | 95% |
| Stage #1: 1-acetamido-3,5-dimethyladamantane With sodium hydroxide In ethylene glycol at 150 - 160℃; for 0.5h; Large scale; Stage #2: With hydrogenchloride In ethyl acetate Large scale; | 82.78% |
| Conditions | Yield |
|---|---|
| Stage #1: 3,5-dimethyl-1-bromoadamantane; urea In 1-methyl-pyrrolidin-2-one at 120℃; for 4h; Stage #2: With sodium hydroxide In 1-methyl-pyrrolidin-2-one at 120℃; for 6h; Stage #3: With hydrogenchloride In 1-methyl-pyrrolidin-2-one; water at 25℃; for 16h; Solvent; Temperature; | 97% |
- 351329-88-9
1-formamido-3,5-dimethyltricyclo[3.3.1.13,7]decane
- 41100-52-1
memantine hydrochloride
| Conditions | Yield |
|---|---|
| With hydrogenchloride In water at 100℃; for 5h; | 94% |
| Stage #1: 1-formamido-3,5-dimethyltricyclo[3.3.1.13,7]decane With water; sodium hydroxide In methanol for 12h; Reflux; Stage #2: With hydrogenchloride In methanol; n-heptane at 60 - 65℃; Product distribution / selectivity; | 86% |
| With hydrogenchloride In hexane; water for 2.5h; Reflux; | 84.65% |
- 1309688-17-2
N-((1,3,5,7)-3,5-dimethyladamantan-1-yl)-1,1,1-trifluoromethanesulfonamide
- 41100-52-1
memantine hydrochloride
| Conditions | Yield |
|---|---|
| Stage #1: N-((1,3,5,7)-3,5-dimethyladamantan-1-yl)-1,1,1-trifluoromethanesulfonamide With potassium carbonate; 1-bromomethyl-4-nitro-benzene In acetone at 20℃; Stage #2: With caesium carbonate In tetrahydrofuran at 50℃; for 14h; Stage #3: With hydrogenchloride In tetrahydrofuran; water | 92% |
- 19982-08-2
memantine*
- 41100-52-1
memantine hydrochloride
| Conditions | Yield |
|---|---|
| With hydrogenchloride In water; acetone at -5 - 30℃; for 5h; | 91.9% |
| With hydrogenchloride pH=6; Gas phase; | 88% |
| With hydrogenchloride In water; acetone at 0 - 10℃; Solvent; | 88% |
- 6588-68-7
1-nitro-3,5-dimethyl-adamantane
- 41100-52-1
memantine hydrochloride
| Conditions | Yield |
|---|---|
| Stage #1: 1-nitro-3,5-dimethyl-adamantane With iron; acetic acid at 20℃; for 4.5h; Stage #2: With hydrogenchloride In ethyl acetate for 0.5h; | 449.2 g |
- 41100-52-1
memantine hydrochloride
| Conditions | Yield |
|---|---|
| Multi-step reaction with 2 steps 1.1: ammonia / dichloromethane; water / 0.5 h / 25 - 30 °C / pH 9.5 - 10.0 2.1: sodium hydroxide / diethylene glycol / 10 h / Heating / reflux 2.2: 2 h / 10 - 15 °C View Scheme |
- 40430-57-7
3, 5-dimethyl-1-adamantyl methyl ketone
- 41100-52-1
memantine hydrochloride
| Conditions | Yield |
|---|---|
| Multi-step reaction with 2 steps 1: methanol; O-benzenesulfonyl-acetohydroxamic acid ethyl ester; toluene-4-sulfonic acid / 12 h / Inert atmosphere; Reflux 2: hydrogenchloride / acetone / 3 h / 23 °C / Inert atmosphere View Scheme |
- 10160-24-4
7-bromoheptyl alcohol
- 41100-52-1
memantine hydrochloride
- 1402933-70-3
7-((3,5-dimethyladamantan-1-yl)amino)heptan-1-ol
| Conditions | Yield |
|---|---|
| With potassium carbonate In N,N-dimethyl-formamide at 80℃; for 48h; | 92% |
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Chemistry
Molecular Structure of Memantine hydrochloride (CAS NO.41100-52-1):
IUPAC Name: 3,5-dimethyladamantan-1-amine hydrochloride
Molecular formula:C12H22ClN
Molecular Weight:215.76
H bond acceptors: 1
H bond donors: 2
Freely Rotating Bonds: 1
Flash Point: 92.3 °C
Enthalpy of Vaporization: 47.67 kJ/mol
Boiling Point: 239.8 °C at 760 mmHg
Vapour Pressure: 0.0393 mmHg at 25°C
EINECS: 255-219-6
Melting point: 292 °C
Appearance:Crystalline Solid
InChI
InChI=1/C12H21N.ClH/c1-10-3-9-4-11(2,6-10)8-12(13,5-9)7-10;/h9H,3-8,13H2,1-2H3;1H
Smiles
C1[C@@]2(CC3(CC(C2)C[C@@]1(C3)C)N)C.Cl
Product Categories: Adamantane derivatives; Antispasmodic; Antiparkinsonian; Adamantanes; Intermediates & Fine Chemicals; Pharmaceuticals; Glutamate receptor; Glutamate
Uses
Memantine hydrochloride is used as an antiparkinsonian and antispasmodic.
Safety Profile
The Safety Statements information of Memantine hydrochloride (CAS NO.41100-52-1):
24/25: Avoid contact with skin and eyes
WGK Germany: 3
Specification
Memantine hydrochloride , with CAS number of 41100-52-1, can be called Memantine HCl ; 1,3-Dimethyl-5-aminoadamantane hydrochloride ; 1,3-Dimethylaminoadamantane hydrochloride ; 1-amino-3,5-dimethyladamantane hcl ; 1-amino-3,5-dimethyladamantane hydrochloride ; 1-amino-3,4-dimethyladamantane hydrochloride . It is a crystalline solid, Memantine hydrochloride (CAS NO.41100-52-1) can be used as an antiparkinsonian and antispasmodic.