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| CAS No.: | 305-84-0 |
|---|---|
| Name: | L-Carnosine |
| Article Data: | 29 |
| Molecular Structure: | |
|
|
|
| Formula: | C9H14N4O3 |
| Molecular Weight: | 226.235 |
| Synonyms: | beta-Alanyl-L-histidine;L-Carnosine 99% min.;N-2-M;L-Carnosinc;β-Alanyl-L-histidine;L-Carnosine Acetate;Karnozin;2-(3-aminopropanoylamino)-3-(3H-imidazol-4-yl)propanoic acid;L-Histidine, N-.beta.-alanyl-;Nalpha-(beta-alanyl)-L-histidine;(2S)-2-(3-aminopropanoylamino)-3-(3H-imidazol-4-yl)propanoic acid;.beta.-Alanyl-L-histidine;Ignotine; |
| EINECS: | 206-169-9 |
| Density: | 1.41 g/cm3 |
| Melting Point: | 253 °C (dec.)(lit.) |
| Boiling Point: | 511.7 °C at 760 mmHg |
| Flash Point: | 263.3 °C |
| Solubility: | almost transparency |
| Appearance: | crystalline |
| Hazard Symbols: |
 Xn
|
| Risk Codes: | 20/21/22-36/37/38 |
| Safety: | 24/25-36-26 |
| PSA: | 121.10000 |
| LogP: | -0.03840 |
| Conditions | Yield |
|---|---|
| Stage #1: N-9-fluorenylmethyloxycarbonyl-N-trityl-L-histidine With trityl chloride polystyrene resin; N-ethyl-N,N-diisopropylamine In dichloromethane; N,N-dimethyl-formamide for 0.5h; trityl chloride resin; Stage #2: With piperazine In dichloromethane; N,N-dimethyl-formamide for 1h; trityl chloride resin; Inert atmosphere; Stage #3: 3-(tert-butyloxycarbonylamino)propionic acid Further stages; | 90% |
| Conditions | Yield |
|---|---|
| With recombinant β-aminopeptidase BapA from Sphingosinicella xenopeptidilytica 3-2W4 at 37℃; pH=10; Kinetics; Reagent/catalyst; pH-value; aq. buffer; Enzymatic reaction; | 53% |
3-aminopropanamide hydrochloride
L-histidine methyl ester dihydrochloride
A
3-(3-Amino-propionylamino)-propionic acid
B
H-(β-Ala)3-NH2
C
H-β-Ala-β-Ala-L-His-OH
E
carnosine
| Conditions | Yield |
|---|---|
| With recombinant β-aminopeptidase DmpA from Ochrobactrum anthropi LMG7991 at 37℃; for 2h; pH=10; aq. buffer; Enzymatic reaction; |
| Conditions | Yield |
|---|---|
| With recombinant β-aminopeptidase BapA from Sphingosinicella xenopeptidilytica 3-2W4 at 37℃; pH=10; Kinetics; Reagent/catalyst; pH-value; aq. buffer; Enzymatic reaction; |
carnosine
| Conditions | Yield |
|---|---|
| With water; sodium hydroxide at 95℃; for 0.116667h; pH=12; aq. buffer; |
| Conditions | Yield |
|---|---|
| With 1-hydroxy-pyrrolidine-2,5-dione; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide In water; acetonitrile at 4℃; for 0.2h; pH=7.5; Reagent/catalyst; Solvent; pH-value; |
| Conditions | Yield |
|---|---|
| Stage #1: 4-(((L-histidyl)oxy)methyl)-N,N,N-trimethylbenzenaminium; Smoc-β-alanine With 1-hydroxy-pyrrolidine-2,5-dione; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide In water; isopropyl alcohol for 0.25h; pH=7.5; Stage #2: With piperazine In water; isopropyl alcohol |
| Conditions | Yield |
|---|---|
| With thionyl chloride for 1h; Reflux; | 100% |
| Conditions | Yield |
|---|---|
| With water; sodium hydroxide In methanol at 25 - 60℃; for 3h; Solvent; | 99.7% |
| With sodium hydroxide In water at 23 - 83℃; for 3h; Solvent; Temperature; | 96.8% |
di-tert-butyl dicarbonate
carnosine
(S)-3-(1-(tert-butoxycarbonyl)-1H-imidazol-5-yl)-2-(3-((tert-butoxycarbonyl)amino)propanamido)propanoic acid
| Conditions | Yield |
|---|---|
| Stage #1: di-tert-butyl dicarbonate; carnosine With sodium hydroxide In 1,3-dioxane; water at 0 - 20℃; Inert atmosphere; Stage #2: With potassium dihydrogenphosphate In 1,3-dioxane; water | 76% |
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Product Name: L-Carnosine
Synonyms: l-Ignotine ; l-Beta-alanine histidine ; Beta-alanyl-l-histidine ; Beta-ala-l-his ; L-Carnosine ; b-Alanyl-l-histidine ; Beta-a-h ; h-Beta-ala-his-oh
IUPAC Name: 2-(3-aminopropanoylamino)-3-(1H-imidazol-5-yl)propanoic acid
The Molecular formula of Carnosine (136572-09-3): C9H14N4O3
The Molecular Weight of Carnosine (136572-09-3): 226.23 g/mol
Molecular Structure : 
EINECS: 206-169-9
Melting point: 253 °C (dec.)(lit.)
alpha: 20.9 o (c=1.5, H2O)
storage temp.: 2-8°C
Appearance: Crystalline
Density: 1.41 g/cm3
Flash Point: 263.3 °C
Index of Refraction: 1.607
Surface Tension: 76.9 dyne/cm
Enthalpy of Vaporization: 82.42 kJ/mol
Boiling Point: 511.7 °C at 760 mmHg
Vapour Pressure: 2.69E-11 mmHg at 25 °C
| Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
|---|---|---|---|---|---|
| mouse | LD50 | intraperitoneal | 9087mg/kg (9087mg/kg) | BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) BEHAVIORAL: MUSCLE CONTRACTION OR SPASTICITY) LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION | United States Patent Document. Vol. #4446149, |
| mouse | LD50 | oral | > 14930mg/kg (14930mg/kg) | BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) BEHAVIORAL: MUSCLE CONTRACTION OR SPASTICITY) LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION | United States Patent Document. Vol. #4446149, |
Reported in EPA TSCA Inventory.
Mildly toxic by intraperitoneal route. An experimental teratogen. Other experimental reproductive effects. When heated to decomposition it emits toxic fumes of NOx.
The Hazard Codes of CARNOSINE(305-84-0): 
Xn
The Risk Statements information of Carnosine (305-84-0): 20/21/22-36/37/38
20/21/22: Harmful by inhalation, in contact with skin and if swallowed
36/37/38: Irritating to eyes, respiratory system and skin
The Safety Statements information of Carnosine (305-84-0): 24/25-36-26
26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice
36: Wear suitable protective clothing
24/25: Avoid contact with skin and eyes
WGK Germany: 2
RTECS: MS3080000
F: 3-10
Chemical Stability: Stable under normal temperatures and pressures.
Conditions to Avoid: Incompatible materials.
Incompatibilities with Other Materials Strong oxidizing agents.
Hazardous Decomposition Products Carbon monoxide, carbon dioxide, nitrogen oxides (NOx) and ammonia (NH3).
Hazardous Polymerization Will not occur.
