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| CAS No.: | 1837-57-6 |
|---|---|
| Name: | 6,9-DIAMINO-2-ETHOXYACRIDINE LACTATE |
| Molecular Structure: | |
|
|
|
| Formula: | C15H15N3O.C3H6O3 |
| Molecular Weight: | 343.382 |
| Synonyms: | Lactic acid, compd. with 6, 9-diamino-2-ethoxyacridine (1:1);Flavitrol;7-ethoxyacridine-3,9-diamine; 2-hydroxypropanoic acid;3,9-Diamino-7-ethoxyacridinium lactate;Acrinol;Hectalin;Amoebin;2-Ethoxy-6,9-diaminoacridine lactate;2,5-Diamino-7-ethoxyacridine lactate;Rivanol;Propanoic acid, 2-hydroxy-, compd. with 7-ethoxy-3,9-acridinediamine (1:1);Acrolactine;Acridine, 6,9-diamino-2-ethoxy-, cpd with lactic acid (1:1);Ethodin;Rimaon;Antidian 200;6,9-Acridinediamine, 2-ethoxy-, 2-hydroxypropanoate (1:1);6, 9-Diamino-2-ethoxyacridine lactate; |
| EINECS: | 217-408-1 |
| Density: | 1.2764 (rough estimate) |
| Melting Point: | 62-67°C(lit.) |
| Boiling Point: | 523.5 °C at 760 mmHg |
| Flash Point: | 270.4 °C |
| Appearance: | White or almost white crystalline powder; none stink |
| Hazard Symbols: |
 Xi, Xn
|
| Risk Codes: | R36/37/38; R22; R40; R20/21/22 |
| PSA: | 131.69000 |
| LogP: | 3.56530 |
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- 1837-57-6
ethacridine lactate
| Conditions | Yield |
|---|---|
| With N-Bromosuccinimide; acetic acid | 85% |
| Conditions | Yield |
|---|---|
| In acetic acid for 0.166667h; | 84% |
| Conditions | Yield |
|---|---|
| Stage #1: ethacridine lactate With sulfuric acid; sodium nitrite In water at 5℃; for 0.333333h; Stage #2: 2.6-diaminopyridine With sodium carbonate In water at 20℃; for 12h; | 76.3% |
| Conditions | Yield |
|---|---|
| Stage #1: ethacridine lactate With sulfuric acid; sodium nitrite In water at 0 - 5℃; for 0.333333h; Stage #2: salicylaldehyde With sodium carbonate In water at 20℃; for 2h; | 75% |
| Conditions | Yield |
|---|---|
| With hydrogenchloride; sodium hydroxide; sodium nitrite 1) H2O, 0 deg C, 2) 5 deg C to 10 deg C; Yield given. Multistep reaction; |
- 1837-57-6
ethacridine lactate
| Conditions | Yield |
|---|---|
| With hydrogenchloride; tetrafluoroboric acid; sodium nitrite 1) H2O, 0 deg C, 2) H2O, 0 deg C; Yield given. Multistep reaction; |
- 1837-57-6
ethacridine lactate
- 74165-94-9
5-Iod-ethacridin
| Conditions | Yield |
|---|---|
| With iodine; potassium iodide |
- 1837-57-6
ethacridine lactate
| Conditions | Yield |
|---|---|
| Multi-step reaction with 2 steps 1: 85 percent / N-bromosuccinimide, aq. AcOH 2: 60 percent / N-bromosuccinimide, aq. AcOH View Scheme |
| Conditions | Yield |
|---|---|
| With potassium iodate In methanol pH=3.1; aq. buffer; |
| Conditions | Yield |
|---|---|
| With sulfuric acid In methanol |
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Chemistry
Chemical Name: 6,9-Diamino-2-ethoxyacridine lactate
IUPAC NAME: 7-Ethoxyacridine-3,9-diamine ; 2-hydroxypropanoic acid
CAS No.: 1837-57-6
EINECS: 217-408-1
Molecular Formula: C18H21N3O4
Molecular Weight: 343.38 g/mol
Flash Point: 270.4 °C
Boiling Point: 523.5 °C at 760 mmHg
Polar Surface Area: 28.6 Å2
Enthalpy of Vaporization: 79.71 kJ/mol
Vapour Pressure: 4.72E-11 mmHg at 25°C
Following is the structure:
The chemical synonymous of Ethacridine lactate (CAS NO.1837-57-6) are 2-Ethoxy-6,9-diaminoacridine lactate ; Acrinol ; 6,9-Diamino-2-ethoxyacridine lactate ; Ethacridine lactate ; Ethodin ; Rivanol ; 2,5-Diamino-7-ethoxyacridinelactate ; 2-Aethoxy-6,9-diaminoacridinlactat
Uses
Ethacridine lactate (CAS NO.1837-57-6) is used as a disinfection antiseptic drug.
Toxicity Data With Reference
| Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
|---|---|---|---|---|---|
| mouse | LD50 | intraperitoneal | 70mg/kg (70mg/kg) | Pharmaceutical Chemistry Journal Vol. 26, Pg. 735, 1993. | |
| mouse | LD50 | subcutaneous | 120mg/kg (120mg/kg) | British Journal of Experimental Pathology. Vol. 28, Pg. 1, 1947. | |
| rabbit | LD50 | subcutaneous | 100mg/kg (100mg/kg) | Drugs in Japan Vol. -, Pg. 6, 1995. | |
| rabbit | LDLo | intravenous | 20mg/kg (20mg/kg) | VASCULAR: SHOCK | Bulletin des Sciences Pharmacologiques. Vol. 40, Pg. 582, 1933. |
Consensus Reports
Reported in EPA TSCA Inventory.
Safety Profile
Poison by subcutaneous, intraperitoneal, and intravenous routes. Experimental reproductive effects. An antiseptic. When heated to decomposition it emits toxic fumes of NOx.
Specification
Ethacridine lactate (CAS NO.1837-57-6) is an aromatic organic compound based on acridine.Its formal name is 2-ethoxy-6,9-diaminoacridine monolactate monohydrate. It forms orange-yellow crystals with a melting point of 226 °C and it has a stinging smell.Its primary use is as an antiseptic in solutions of 0.1%.It is also used as an agent for second trimester abortion. Up to 150 ml of a 0.1% solution is instilled extra-amniotically using a foley catheter. After 20 to 40 hours, 'mini labor' ensues. In China, an intra-amniotic method has also been used. Ethacridine as an abortifacient is found to be safer and better tolerated than 20% hypertonic saline.
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