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Basic Information
| CAS No.: | 1722-12-9 |
|---|---|
| Name: | 2-Chloropyrimidine |
| Article Data: | 42 |
| Molecular Structure: | |
|
|
|
| Formula: | C4H3ClN2 |
| Molecular Weight: | 114.534 |
| Synonyms: | 2 Chloro Pyridine;2-Chlorpyrimidin;2-Chloro-4-deoxyuracil;2-Chloropyrimidine D001;Pyrimidine, 2-chloro-; |
| EINECS: | 217-020-2 |
| Density: | 1.303 g/cm3 |
| Melting Point: | 63-66 °C(lit.) |
| Boiling Point: | 199.2 °C at 760 mmHg |
| Flash Point: | 109.2 °C |
| Solubility: | Slightly soluble in water. 33.3 mg soluble in 1 mL of alcohol. |
| Appearance: | yellowish to pale orange crystals or cryst. powder |
| Hazard Symbols: |
 Xn, Xi
|
| Risk Codes: | 22-36-36/38-36/37/38 |
| Safety: | 26-37/39-36 |
| PSA: | 25.78000 |
| LogP: | 1.13000 |
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Synthetic route
Conditions
| Conditions | Yield |
|---|---|
| With trichlorophosphate Chlorination; | 70% |
- 131242-36-9
2-sulfanylpyrimidine
- 1722-12-9
2-chloropyrimidine
Conditions
| Conditions | Yield |
|---|---|
| Stage #1: 2-sulfanylpyrimidine With trichloroisocyanuric acid; water; benzyltrimethylammonium chloride In acetonitrile at -30 - -25℃; for 0.5h; Stage #2: With isobutylamine In acetonitrile Further stages.; | 70% |
| With hydrogenchloride; sodium hypochlorite In dichloromethane; water | |
| With thionyl chloride; dihydrogen peroxide In water; acetonitrile at 25℃; |
- 1003845-06-4
(2-chloropyrimidin-5-yl)boronic acid
- 1722-12-9
2-chloropyrimidine
Conditions
| Conditions | Yield |
|---|---|
| With 2-bromo-pyridine; tetrakis(triphenylphosphine) palladium(0); sodium carbonate In ethanol; toluene Reflux; | 65% |
Conditions
| Conditions | Yield |
|---|---|
| With tetrakis(triphenylphosphine) palladium(0) In tetrahydrofuran for 24h; Heating; | A 30% B 50% |
...Expand
- 97-93-8
triethylaluminum
- 32779-36-5
5-Bromo-2-chloropyrimidine
A
- 1722-12-9
2-chloropyrimidine
B
- 111196-81-7
2-chloro-5-ethylpyrimidine
Conditions
| Conditions | Yield |
|---|---|
| With tetrakis(triphenylphosphine) palladium(0) In tetrahydrofuran for 24h; Heating; | A 30% B 42% |
...Expand
- 3934-20-1
2,6-Dichloropyrimidine
- 97-93-8
triethylaluminum
A
- 1722-12-9
2-chloropyrimidine
B
- 188707-99-5
2-chloro-4-ethylpyrimidine
Conditions
| Conditions | Yield |
|---|---|
| With tetrakis(triphenylphosphine) palladium(0) In tetrahydrofuran for 24h; Heating; | A 25% B 37% |
...Expand
Conditions
| Conditions | Yield |
|---|---|
| With hydrogenchloride; sodium nitrite In water at -15 - 0℃; for 2.25h; | 34% |
| With hydrogenchloride; sodium nitrite | |
| With hydrogenchloride; zinc(II) chloride; sodium nitrite In dichloromethane; water | |
| With hydrogenchloride; zinc(II) chloride; sodium nitrite In dichloromethane; water | |
| With hydrogenchloride; copper dichloride; sodium nitrite In dichloromethane |
Conditions
| Conditions | Yield |
|---|---|
| With zinc | |
| With potassium acetate; palladium diacetate; bis(pinacol)diborane; tricyclohexylphosphine In 1,4-dioxane at 110℃; for 0.166667h; Inert atmosphere; | |
| With hydrogen In methanol; ethanol at 20℃; |
- 38353-09-2
2-pyrimidinone hydrochloride
- 1722-12-9
2-chloropyrimidine
Conditions
| Conditions | Yield |
|---|---|
| With phosphorus pentachloride; trichlorophosphate | |
| With trichlorophosphate |
- 930-36-9
1-methyl-1H-pyrazole
- 67-66-3
chloroform
A
- 4513-94-4
1H-pyrrole-2-carbonitrile
B
- 1722-12-9
2-chloropyrimidine
C
- 51269-82-0
5-chloronicotinonitrile
Conditions
| Conditions | Yield |
|---|---|
| at 550 - 555℃; Yield given. Title compound not separated from byproducts; | |
| at 550 - 555℃; Title compound not separated from byproducts; |
...Expand
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2-Chloropyrimidine
Chemistry
2-Chloropyrimidine is the chemical compound with the formula C4H3ClN2.Its molecular weight is 114.53.It is white crystalline.
EINECS 217-020-2
Molecular Structure:
Melting point:66 oC
Boiling point:75-76 oC (10 mmHg)
Flash point:98 oC
Storage temp. : Refrigerator
Sensitive : Moisture Sensitive
EINECS 217-020-2
Molecular Structure:
Melting point:66 oC
Boiling point:75-76 oC (10 mmHg)
Flash point:98 oC
Storage temp. : Refrigerator
Sensitive : Moisture Sensitive
Uses
2-Chloropyrimidine is the intermediate of Medicine and 2-Chloropyrimidine also is the intermediate of pesticide
Safety Profile
2-Chloropyrimidine's Hazard Symbols: 
Xi
2-Chloropyrimidine's Risk Codes:
36/38:Irritating to eyes and skin
2-Chloropyrimidine's Safety Description:
26:In case of contact with eyes, rinse immediately with plenty of WATER and seek medical advice
37/39:Wear suitable gloves and eye/face protection
Xi2-Chloropyrimidine's Risk Codes:
36/38:Irritating to eyes and skin
2-Chloropyrimidine's Safety Description:
26:In case of contact with eyes, rinse immediately with plenty of WATER and seek medical advice
37/39:Wear suitable gloves and eye/face protection
Standards and Recommendations
Loss on drying：≤0.3
Content：≥98%
Content：≥98%