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CAS No.: | 156-51-4 |
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Name: | PHENELZINE SULFATE SALT |
Molecular Structure: | |
Formula: | C8H12N2•H2O4S |
Molecular Weight: | 234.276 |
Synonyms: | phenelzinehydrogensulphate |
Melting Point: | 166.5-167.5 °C |
Boiling Point: | 497.4°C at 760 mmHg |
Flash Point: | 254.6°C |
Hazard Symbols: | Xn |
Risk Codes: | 22 |
Safety: | Poison by ingestion, intraperitoneal, intravenous, and subcutaneous routes. Human systemic effects by ingestion: wakefulness, blood pressure lowering, constipation, hepatitis, fibrous hepatitis. Experimental reproductive effects. Questionable carcinogen with experimental neoplastigenic data. Mutation data reported. Used as a drug for the treatment of depression. When heated to decomposition it emits very toxic fumes of SOx and NOx. |
PSA: | 121.03000 |
LogP: | 2.21160 |
3-(pyridine-2-yl)-3-oxopropanenitrile
2-phenethylhydrazine sulfate
2-phenethyl-5-pyridin-2-yl-2H-pyrazol-3-ylamine
Conditions | Yield |
---|---|
With triethylamine In ethanol for 2h; Inert atmosphere; Reflux; | 87% |
With triethylamine In ethanol at 20℃; for 2h; Inert atmosphere; Reflux; | 87% |
Conditions | Yield |
---|---|
With sodium ethanolate In tetrahydrofuran; ethanol at 0℃; Inert atmosphere; regioselective reaction; | 81% |
2-phenethylhydrazine sulfate
Conditions | Yield |
---|---|
In sulfuric acid aq. H2SO4; (aerobic conditions); addn. of the org. salt to a hot filtered soln. of the metal sulfate in aq. H2SO4, stirring (50-60°C, 30 min); storage (room temp., overnight), filtration, washing (H2O; EtOH; Et2O), drying (vac., P4O10); elem. anal.; | 75% |
Conditions | Yield |
---|---|
With triethylamine In N,N-dimethyl-formamide at 20℃; | 73% |
2-phenethylhydrazine sulfate
4-(2-tert-butoxycarbonyl-2-oxo-ethyl)-5-oxo-pyrrolidine-1,2-dicarboxylic acid di-tert-butyl ester
Conditions | Yield |
---|---|
With sodium acetate In methanol for 2h; Ambient temperature; | 70% |
2-phenethylhydrazine sulfate
Conditions | Yield |
---|---|
In sulfuric acid aq. H2SO4; (aerobic conditions); addn. of the org. salt to a hot filtered soln. of the metal sulfate in aq. H2SO4, stirring (50-60°C, 30 min); storage (room temp., overnight), filtration, washing (H2O; EtOH; Et2O), drying (vac., P4O10); elem. anal.; | 70% |
2-phenethylhydrazine sulfate
Conditions | Yield |
---|---|
In sulfuric acid aq. H2SO4; (aerobic conditions); addn. of the org. salt to a hot filtered soln. of the metal sulfate in aq. H2SO4, stirring (50-60°C, 30 min); storage (room temp., overnight), filtration, washing (H2O; EtOH; Et2O), drying (vac., P4O10); elem. anal.; | 70% |
2-phenethylhydrazine sulfate
Conditions | Yield |
---|---|
In sulfuric acid aq. H2SO4; (aerobic conditions); addn. of the org. salt to a hot filtered soln. of the metal sulfate in aq. H2SO4, stirring (50-60°C, 30 min); storage (room temp., overnight), filtration, washing (H2O; EtOH; Et2O), drying (vac., P4O10); elem. anal.; | 68% |
2-phenethylhydrazine sulfate
Conditions | Yield |
---|---|
In sulfuric acid aq. H2SO4; (aerobic conditions); addn. of the org. salt to a hot filtered soln. of the metal sulfate in aq. H2SO4, stirring (50-60°C, 30 min); storage (room temp., overnight), filtration, washing (H2O; EtOH; Et2O), drying (vac., P4O10); elem. anal.; | 67% |
2-phenethylhydrazine sulfate
ethyl (ethoxymethylene)cyanoacetate
ethyl 5-amino-1-(2-phenylethyl)-1H-pyrazole-4-carboxylate
Conditions | Yield |
---|---|
Stage #1: 2-phenethylhydrazine sulfate With sodium ethanolate In ethanol at 20℃; for 1h; Inert atmosphere; Stage #2: ethyl (ethoxymethylene)cyanoacetate In ethanol at 0 - 70℃; for 14.5h; Inert atmosphere; regioselective reaction; | 67% |
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IUPAC Name: Phenethylhydrazine; sulfuric acid
Synonyms: Phenelzine hydrogen sulphate ; (2-Phenethyl)hydrazine Dihydrogen Sulfate ; (2-Phényléthyl)hydrazine sulfate ; (2-Phenylethyl)hydrazine sulfate (1:1) ; (2-Phenylethyl)hydrazinsulfat ; B-Phenylethylhydrazine Dihydrogen Sulfate ; Hydrazine, (2-phenylethyl)-, sulfate (1:1)
Product Categories: Monoamine oxidase inhibitor;Monoamine OxidaseEnzyme Inhibitors by Enzyme;Enzyme Inhibitors;L to;Neurotransmitter Metabolism
CAS NO: 156-51-4
Molecular Formula of beta-Phenylethylhydrazine sulfate (CAS NO.156-51-4) : C8H14N2O4S
Molecular Weight of beta-Phenylethylhydrazine sulfate (CAS NO.156-51-4) : 234.27
Molecular Structure of beta-Phenylethylhydrazine sulfate (CAS NO.156-51-4) :
EINECS: 205-856-0
Mol File: 156-51-4.mol
Merck : 13,7300
Flash Point: 143.7 °C
Enthalpy of Vaporization: 52.02 kJ/mol
Boiling Point: 281.4 °C at 760 mmHg
Vapour Pressure: 0.00358 mmHg at 25°C
1. | mma-sat 800 µg/plate | NEZAAQ Nippon Eiseigaku Zasshi. Japanese Journal of Hygiene. 33 (1978),474. | ||
2. | dnr-esc 4300 nmol/plate | JTEHD6 Journal of Toxicology and Environmental Health. 9 (1982),287. | ||
3. | orl-mus TDLo:28 g/kg/77W-C:NEO | CNREA8 Cancer Research. 36 (1976),917. | ||
4. | orl-hmn TDLo:1070 µg/kg/D:CNS,GIT,CVS | 34ZIAG Toxicology of Drugs and Chemicals ,Deichmann, W.B.,New York, NY.: Academic Press, Inc.,1969,461. | ||
5. | orl-man TDLo:46 mg/kg/10W-I:LIV, | AJMEAZ American Journal of Medicine. 80 (1986),689. | ||
6. | orl-wmn TDLo:18 mg/kg | ANASAB Anaesthesia. 41 (1986),53. | ||
7. | orl-rat LD50:210 mg/kg | ANYAA9 Annals of the New York Academy of Sciences. 107 (1963),899. | ||
8. | orl-mus LD50:156 mg/kg | ANYAA9 Annals of the New York Academy of Sciences. 107 (1963),899. | ||
9. | ipr-mus LD50:162 mg/kg | JMCMAR Journal of Medicinal Chemistry. 18 (1975),20. | ||
10. | scu-mus LD50:125 mg/kg | JOENAK Journal of Endocrinology. 30 (1964),205. | ||
IARC Cancer Review: Group 3 IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man . 7 ,1987,p. 312.(World Health Organization, Internation Agency for Research on Cancer,Lyon, France.: ) (Single copies can be ordered from WHO Publications Centre U.S.A., 49 Sheridan Avenue, Albany, NY 12210) ; Human Inadequate Evidence IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man . 24 ,1980,p. 175.(World Health Organization, Internation Agency for Research on Cancer,Lyon, France.: ) (Single copies can be ordered from WHO Publications Centre U.S.A., 49 Sheridan Avenue, Albany, NY 12210) ; Animal Limited Evidence IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man . 24 ,1980,p. 175.(World Health Organization, Internation Agency for Research on Cancer,Lyon, France.: ) (Single copies can be ordered from WHO Publications Centre U.S.A., 49 Sheridan Avenue, Albany, NY 12210) . EPA Genetic Toxicology Program.
Poison by ingestion, intraperitoneal, intravenous, and subcutaneous routes. Human systemic effects by ingestion: wakefulness, blood pressure lowering, constipation, hepatitis, fibrous hepatitis. Experimental reproductive effects. Questionable carcinogen with experimental neoplastigenic data. Mutation data reported. Used as a drug for the treatment of depression. When heated to decomposition it emits very toxic fumes of SOx and NOx.
Hazard Codes Xn
Risk Statements 22
R22:Harmful if swallowed.
RIDADR UN 2811 6.1/PG 3
WGK Germany 3
RTECS MV8750000
HazardClass 6.1(b)
PackingGroup III