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| CAS No.: | 1480-96-2 |
|---|---|
| Name: | 2-Methoxy-5-fluorouracil |
| Article Data: | 5 |
| Molecular Structure: | |
|
|
|
| Formula: | C5H5FN2O2 |
| Molecular Weight: | 144.105 |
| Synonyms: | 4(1H)-Pyrimidinone,5-fluoro-2-methoxy- (9CI);4(3H)-Pyrimidinone, 5-fluoro-2-methoxy- (6CI,8CI);NSC 527067; |
| EINECS: | 473-810-9 |
| Density: | 1.44 g/cm3 |
| Melting Point: | 204-208 °C(lit.) |
| Boiling Point: | 225.1℃[at 101 325 Pa] |
| Solubility: | 5.49g/L at 20℃ |
| Hazard Symbols: |
 Xi
|
| Risk Codes: | 36/37/38 |
| Safety: | 26-36 |
| PSA: | 55.24000 |
| LogP: | 0.32990 |
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2-methoxy-5-fluorouracil
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sodium methylate
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2-methoxy-5-fluorouracil
| Conditions | Yield |
|---|---|
| Stage #1: formic acid ethyl ester With sodium methylate In toluene at 10 - 20℃; Large scale; Stage #2: methyl fluoroacetate In toluene at 8 - 40℃; for 20h; Large scale; Stage #3: O-methylisourea hydrosulfate With sodium methylate In methanol at 40℃; for 6h; Large scale; |
| Conditions | Yield |
|---|---|
| With triethylamine; trichlorophosphate In toluene at 50 - 80℃; | 95% |
| With N,N-dimethyl-aniline; trichlorophosphate at 110℃; for 1.5h; | 34% |
| Conditions | Yield |
|---|---|
| With hydrogenchloride In methanol at 28℃; for 5h; Temperature; | 78.3% |
| With hydrogenchloride In water at 55℃; for 3h; Large scale; | 65.24 kg |
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Chemistry
Molecular structure of 2-Methoxy-5-fluorouracil (CAS NO.1480-96-2) is:
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Product Name: 2-Methoxy-5-fluorouracil
CAS Registry Number: 1480-96-2
IUPAC Name: 5-fluoro-2-methoxy-1H-pyrimidin-6-one
Molecular Weight: 144.103803 [g/mol]
Molecular Formula: C5H5FN2O2
XLogP3-AA: 0
H-Bond Donor: 1
H-Bond Acceptor: 4
Melting Point: 204-208 °C(lit.)
Index of Refraction: 1.536
Molar Refractivity: 31.06 cm3
Molar Volume: 99.5 cm3
Surface Tension: 39.4 dyne/cm
Density: 1.44 g/cm3
Product Categories: PYRIMIDINE;Pyridines, Pyrimidines, Purines and Pteredines;INTERMEDIATESOFFINASTERIDE;Heterocyclic Compounds;Bases & Related Reagents;Heterocycles;Nucleotides;Building Blocks;Heterocyclic Building Blocks;Pyrimidines
Safety Profile
Safty information about 2-Methoxy-5-fluorouracil (CAS NO.1480-96-2) is:
Hazard Codes: 
Xi
Risk Statements: 36/37/38
R36/37/38:Irritating to eyes, respiratory system and skin.
Safety Statements: 26-36
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
S36:Wear suitable protective clothing.
WGK Germany: 3
Specification
2-Methoxy-5-fluorouracil , its cas register number is 1480-96-2. It also can be called 4(3H)-Pyrimidinone,5-fluoro-2-methoxy- ; 5-Fluoro-2-methoxy-4(1H)pyrimidinone .