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| CAS No.: | 1188-21-2 |
|---|---|
| Name: | N-Acetyl-L-leucine |
| Article Data: | 45 |
| Molecular Structure: | |
|
|
|
| Formula: | C8H15NO3 |
| Molecular Weight: | 173.212 |
| Synonyms: | Leucine,N-acetyl-, L- (8CI);(S)-2-Acetamido-4-methylpentanoic acid;Acetyl-L-leucine;Acetylleucine;N-Acetyl-L-(-)-leucine; |
| EINECS: | 214-706-3 |
| Density: | 1.069 g/cm3 |
| Melting Point: | 187-190 °C(lit.) |
| Boiling Point: | 369.7 °C at 760mmHg |
| Flash Point: | 177.4 °C |
| Solubility: | 0.81 g/100 mL (20 °C) in water |
| Appearance: | white crystalline powder |
| Hazard Symbols: |
 Xi
|
| Risk Codes: | 36/37/38 |
| Safety: | 24/25-36-26 |
| PSA: | 66.40000 |
| LogP: | 1.01270 |
(Z)-2-Acetylamino-4-methyl-pent-2-enoic acid
N-Ac-Leu
| Conditions | Yield |
|---|---|
| With hydrogen; rhodium(I)-bis(1,5-cyclooctadiene) tetrafluoroborate; triethylamine; (2R,2'R)-bis(diphenylphosphino)-(1R,1'R)-dicyclopentane In tetrahydrofuran at 20℃; under 750.075 Torr; for 24h; | 100% |
| With hydrogen; Rh(I)-(S)-chairphos In tetrahydrofuran Product distribution; Ambient temperature; other catalyst; other solvents; influence on products' optical yields; | |
| With hydrogen; (S)-(-)-(6,6’-dimethoxybiphenyl-2,2’-diyl)bis(diphenylphosphine); [rhodium(I)(norborna-2,5-diene)2]SbF6 In dichloromethane at 20℃; under 1292.87 Torr; for 24h; | |
| With chiral (1,1'-ferrocenediyl)bis(phospholo[3,4-d][1,3]dioxole); hydrogen; bis(1,5-cyclooctadiene)rhodium(I) hexafluorophosphate In tetrahydrofuran at 20℃; under 775.743 Torr; for 1h; |
| Conditions | Yield |
|---|---|
| In water for 0.0666667h; Irradiation; | 98% |
| With sodium hydrogencarbonate In water at 0 - 20℃; for 5h; | 89% |
| With triethylamine In water at 20℃; | 35% |
methyl N-acetyl-leucinate
A
N-Ac-Leu
B
methyl (R)-2-(N-acetylamino)-4-methylpentanoate
| Conditions | Yield |
|---|---|
| With sodium hydroxide; phosphate buffer; pronase EC 3.4.24.4 In tetrahydrofuran Ambient temperature; | A 79% B 91% |
| Conditions | Yield |
|---|---|
| at 0 - 20℃; | 89% |
(S)-benzyl 2-acetamido-4-methylpentanoate
N-Ac-Leu
| Conditions | Yield |
|---|---|
| With palladium 10% on activated carbon; hydrogen In ethanol at 50℃; for 3h; | 81% |
| With palladium 10% on activated carbon; hydrogen In ethanol at 50℃; for 3h; | 81% |
| Conditions | Yield |
|---|---|
| With sodium hydroxide |
| Conditions | Yield |
|---|---|
| With (-)-α-fenchylamine |
methyl N-acetyl-leucinate
N-Ac-Leu
| Conditions | Yield |
|---|---|
| for 118h; carbonate hydrolyase EC 4.2.2.1 (bovine carbonic anhydrase, BCA), pH 7.5; Yield given. Yields of byproduct given. Title compound not separated from byproducts; |
| Conditions | Yield |
|---|---|
| In ethanol; water at 35℃; for 48h; Yield given; |
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1. Introduction of N-Acetyl-L-leucine
N-Acetyl-L-leucine, with the IUPAC Name: (2S)-2-acetamido-4-methylpentanoic acid, is one kind of powder.
And it belongs to the Product Categories which include Amino Acids Derivatives; Amino Acid Derivatives; Amino Acids; Leucine [Leu, L]; Amino Acids and Derivatives; Ac-Amino Acids; Amino Acids (N-Protected); Biochemistry; N-Acetyl-Amino acid series; Amino Acid Derivatives; Leucine; Peptide Synthesis. When comes to the application, it is one type of biochemical reagent.
2. Properties of N-Acetyl-L-leucine
N-Acetyl-L-leucine has the following property datas: (1)XLogP3: 0.5; (2)H-Bond Donor: 2; (3)H-Bond Acceptor: 3; (4)EINECS: 214-706-3; (5)Melting Point: 187-190 °C(lit.); (6)Surface Tension: 37.2 dyne/cm; (7)Water Solubility: 0.81 g/100 mL (20 °C); (8)Density: 1.069 g/cm3; (9)Flash Point: 177.4 °C; (10)Enthalpy of Vaporization: 67.7 kJ/mol; (11)Boiling Point: 369.7 °C at 760 mmHg; (12)Vapour Pressure: 1.77E-06 mmHg at 25°C. When comes to the usage, it could be used for treating vestibular-related imbalance and vertigo.
3. Safty information about N-Acetyl-L-leucine
Hazard Codes: 
Xi
Risk Statements: 36/37/38
R36/37/38:Irritating to eyes, respiratory system and skin.
Safety Statements: 24/25-36-26
S24/25:Avoid contact with skin and eyes.
S36:Wear suitable protective clothing.
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
WGK Germany: 3
HazardClass: IRRITANT
