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CAS No.: | 1125-60-6 |
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Name: | 5-Aminoisoquinoline |
Article Data: | 59 |
Molecular Structure: | |
Formula: | C9H8N2 |
Molecular Weight: | 144.176 |
Synonyms: | 5-Amino-isoquinoline;Isoquinoline, 5-amino- (8CI);5-Isoquinolinamine;isoquinolin-5-amine;Isoquinoline, 5-amino-;Isoquinol-5-ylamine;5-Amino Isoquinoline; |
EINECS: | 214-408-3 |
Density: | 1.21g/cm3 |
Melting Point: | 127-130 °C |
Boiling Point: | 335.7 °C at 760 mmHg |
Flash Point: | 183.3 °C |
Appearance: | yellow to brown crystalline powder |
Hazard Symbols: | Xn,Xi |
Risk Codes: | 38-20/21/22-36/37/38 |
Safety: | 36/37/39-26-37/39-36 |
PSA: | 38.91000 |
LogP: | 2.39820 |
Conditions | Yield |
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With indium; ammonium chloride In ethanol for 1h; Heating; | 99% |
With palladium 10% on activated carbon; hydrogen at 20℃; for 1h; | 99% |
With indium; ammonium chloride In ethanol Heating; | 99% |
5-bromoisoquinoline
isoquinolin-5-ylamine
Conditions | Yield |
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With 2-((dicyclohexylphosphino)methyl)-1,3-bis(2,6-diisopropylphenyl)-4,5-dimethyl-1H-imidazol-3-ium iodide; ammonia; palladium diacetate; sodium t-butanolate In 1,4-dioxane at 120℃; under 7500.75 Torr; for 24h; Autoclave; Inert atmosphere; | 99% |
With lithium amide; (CyPF-t-Bu)PdCl2 In 1,2-dimethoxyethane at 90℃; for 24h; | 79% |
With ammonia; palladium diacetate; sodium t-butanolate; 2-(di-tert-butyl-phosphino)-1-phenyl-1H-pyrrole In 1,4-dioxane at 120℃; under 7500.75 Torr; for 24h; Autoclave; Inert atmosphere; | 78 %Chromat. |
5-Nitroisoquinoline N-Oxide
isoquinolin-5-ylamine
Conditions | Yield |
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With titanium(III) chloride In acetic acid at 18℃; for 0.116667h; | 97.8% |
With hydrogenchloride; palladium on activated charcoal Hydrogenation; |
5-nitroisoquinoline hydrobromide
isoquinolin-5-ylamine
Conditions | Yield |
---|---|
With titanium(III) chloride In acetic acid at 20℃; for 0.116667h; | 86.8% |
Conditions | Yield |
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Stage #1: 5-bromoisoquinoline With lithium amide; [(CyPF-tBu)PdCl2] In 1,2-dimethoxyethane at 90℃; for 24h; Sealed vial; Stage #2: With hydrogenchloride In 1,2-dimethoxyethane; water at 20℃; for 0.0833333h; Stage #3: With sodium hydrogencarbonate In 1,2-dimethoxyethane; water Product distribution / selectivity; | A 79% B n/a |
Stage #1: 5-bromoisoquinoline With ammonia; sodium t-butanolate; [(CyPF-tBu)PdCl2] In 1,2-dimethoxyethane at 90℃; under 4137.29 - 10343.2 Torr; for 20h; Stage #2: With hydrogenchloride In 1,2-dimethoxyethane; water at 20℃; for 0.0833333h; Stage #3: With sodium hydrogencarbonate In 1,2-dimethoxyethane; water Product distribution / selectivity; | A 70% B n/a |
Conditions | Yield |
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With ammonium sulfate; C39H45FeNNiP2; sodium t-butanolate In 2-methyltetrahydrofuran at 100℃; for 7h; Reagent/catalyst; Solvent; Inert atmosphere; Glovebox; Autoclave; | 75% |
Conditions | Yield |
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With sodium tetrahydroborate; 5%-palladium/activated carbon; hydrazine hydrate; lithium hydroxide In 1,4-dioxane at 170℃; for 16h; Molecular sieve; Inert atmosphere; | 30% |
With ammonium hydroxide; sulfur dioxide at 150 - 160℃; |
5-amino-1-chloroisoquinoline
isoquinolin-5-ylamine
Conditions | Yield |
---|---|
With dihydrogen hexachloroplatinate; sodium hydroxide; nickel Hydrogenation; |
5-Nitroisoquinoline N-Oxide
A
isoquinolin-5-ylamine
B
1,2,3,4-tetrahydroisoquinolin-5-amine
Conditions | Yield |
---|---|
With hydrogenchloride; palladium on activated charcoal Hydrogenation; |
Conditions | Yield |
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With palladium on activated charcoal; ethanol Hydrogenation; |
IUPAC Name: isoquinolin-5-amine
Molecular Formula:C9H8N2
Molecular Weight:144.173220 g/mol
Appearance:Light Yellow Solid
Density:1.21g/cm3
Melting Point:125-128 °C
Flash Point:183.3 °C
Sensitive:Light
EINECS:214-408-3
BRN:114465
Synonyms of 5-AMINO ISOQUINOLINE(1125-60-6):
5-Aminoisoquinoline;TIMTEC-BB SBB004127;ISOQUINOLIN-5-YLAMINE;5-AMINOISOQUINOLINE;Isoquinoline, 5-amino-;isoquinol-5-ylamine;isoquinolin-5-amine;5-Aminoisoquinoline ,99%;5-Isoquinolinamine
Categories of 5-AMINO ISOQUINOLINE(1125-60-6):
Amines;Quinolines, Isoquinolines & Quinoxalines;Quinoline&Isoquinoline;Aromatics Compounds;Aromatics;Quinolines, Isoquinolines & Quinoxalines;Building Blocks;Heterocyclic Building Blocks;Isoquinolines
First Aid Measures of 5-AMINO ISOQUINOLINE(1125-60-6):
Ingestion:Never give anything by mouth to an unconscious person. Get medical aid. Do NOT induce vomiting. If conscious and alert, rinse mouth and drink 2-4 cupfuls of milk or water.
Inhalation:Remove from exposure to fresh air immediately. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Get medical aid.
Skin:Get medical aid. Flush skin with plenty of soap and water for at least 15 minutes while removing contaminated clothing and shoes. Wash clothing before reuse.
Eyes:Flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. Get medical aid.
Storage of 5-AMINO ISOQUINOLINE(1125-60-6):
Store in a tightly closed container. Store in a cool, dry, well-ventilated area away from incompatible substances.