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CAS No.: | 1056624-11-3 |
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Name: | 2-(4-(piperazin-1-yl)phenyl)pyrimidine hydrochloride |
Article Data: | 3 |
Molecular Structure: | |
Formula: | C14H16N4.ClH |
Molecular Weight: | 276.769 |
Synonyms: | 2,4,6,8-Tetrahydroxy-pyrimido[5,4-d]pyrimidine |
Appearance: | Yellow power |
PSA: | 41.05000 |
LogP: | 2.74900 |
4-(4-pyrimidin-2-yl-phenyl)-piperazine-1-carboxylic acid tert-butyl ester
2-(4-piperazin-1-yl-phenyl)-pyrimidine hydrochloride
Conditions | Yield |
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With hydrogenchloride In 1,4-dioxane; dichloromethane | |
With hydrogenchloride In 1,4-dioxane; dichloromethane for 2h; | |
With hydrogenchloride In 1,4-dioxane; dichloromethane for 2h; |
2-(4-piperazin-1-yl-phenyl)-pyrimidine hydrochloride
Conditions | Yield |
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Multi-step reaction with 3 steps 1.1: ammonium chloride / tetrahydrofuran; hexanes; water / 0.08 h 1.2: 1 h 2.1: potassium carbonate / bis-triphenylphosphine-palladium(II) chloride / water; N,N-dimethyl-formamide / 8 h / 80 °C 3.1: hydrogenchloride / 1,4-dioxane; dichloromethane / 2 h View Scheme |
tert-butyl 4-(4-bromophenyl)piperazine-1-carboxylate
2-(4-piperazin-1-yl-phenyl)-pyrimidine hydrochloride
Conditions | Yield |
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Multi-step reaction with 4 steps 1.1: n-butyllithium / tetrahydrofuran; hexanes / 0.5 h / -78 °C 1.2: 18.17 h / 20 °C 2.1: ammonium chloride / tetrahydrofuran; hexanes; water / 0.08 h 2.2: 1 h 3.1: potassium carbonate / bis-triphenylphosphine-palladium(II) chloride / water; N,N-dimethyl-formamide / 8 h / 80 °C 4.1: hydrogenchloride / 1,4-dioxane; dichloromethane / 2 h View Scheme |
4-(4-(tert-butoxycarbonyl)piperazin-1-yl)phenylboronic acid
2-(4-piperazin-1-yl-phenyl)-pyrimidine hydrochloride
Conditions | Yield |
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Multi-step reaction with 2 steps 1: potassium carbonate / bis-triphenylphosphine-palladium(II) chloride / water; N,N-dimethyl-formamide / 8 h / 80 °C 2: hydrogenchloride / 1,4-dioxane; dichloromethane / 2 h View Scheme |
2-(4-piperazin-1-yl-phenyl)-pyrimidine hydrochloride
Conditions | Yield |
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Multi-step reaction with 5 steps 1.1: triethylamine / dichloromethane / 1 h 2.1: n-butyllithium / tetrahydrofuran; hexanes / 0.5 h / -78 °C 2.2: 18.17 h / 20 °C 3.1: ammonium chloride / tetrahydrofuran; hexanes; water / 0.08 h 3.2: 1 h 4.1: potassium carbonate / bis-triphenylphosphine-palladium(II) chloride / water; N,N-dimethyl-formamide / 8 h / 80 °C 5.1: hydrogenchloride / 1,4-dioxane; dichloromethane / 2 h View Scheme |
1-carboxymethyl-pyrrolidine-3-carboxylic acid methyl ester
2-(4-piperazin-1-yl-phenyl)-pyrimidine hydrochloride
1-{2-oxo-2-[4-(4-pyrimidin-2-yl-phenyl)-piperazin-1-yl]-ethyl}-pyrrolidine-3-carboxylic acid methyl ester
Conditions | Yield |
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With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine In N,N-dimethyl-formamide for 24h; |
1-tert-butoxycarbonylmethyl-3-methoxymethyl-pyrrolidine-3-carboxylic acid methyl ester
2-(4-piperazin-1-yl-phenyl)-pyrimidine hydrochloride
3-methoxymethyl-1-{2-oxo-2-[4-(4-pyrimidin-2-yl-phenyl)-piperazin-1-yl]-ethyl}-pyrrolidine-3-carboxylic acid methyl ester
Conditions | Yield |
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With N-ethyl-N,N-diisopropylamine; HATU In 1,2-dimethoxyethane for 4h; |
2-(4-piperazin-1-yl-phenyl)-pyrimidine hydrochloride
chloroacetyl chloride
Conditions | Yield |
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With triethylamine In dichloromethane at 0℃; for 0.5h; |