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CAS No.: | 10236-47-2 |
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Name: | Naringin |
Article Data: | 9 |
Molecular Structure: | |
Formula: | C27H32O14 |
Molecular Weight: | 580.543 |
Synonyms: | Nvaringin;Momordica grosvenori Extract;schizandra extract;Naringin 98% (HPLC);PolymethoxyLatecl Flavones (Nobiletin);Naringoside;4H-1-Benzopyran-4-one,7-[[2-O-(6-deoxy- R-L-mannopyranosyl)-a-D-glucopyranosyl]- oxy]-2,3-dihydro-5-hydroxy-2-(4-hydroxyphenyl)-,(2S)-;Naringenin 7-O-[beta-L-rhamnosyl-(1->2)-beta-D-glucoside];45-diOH-Flavone-7-rhgluc;Naringenin 7-O-neohesperidoside;7-[[2-O-(6-Deoxy-.alpha.-L-mannopyranosyl)-.beta.-D-glucopyranosyl]oxy]-5-hydroxy-2(S)-(4-hydroxyphenyl)-4H-1-benzopyran-4-one;7-(2-O-(6-deoxy-α-L-mannopyranosyl)-β-D-glucopyranosyloxy)-2,3-dihydro-4',5,7-trihydroxyflavone; |
EINECS: | 233-566-4 |
Density: | 1.66 g/cm3 |
Melting Point: | 166 °C |
Boiling Point: | 928.1 °C at 760 mmHg |
Flash Point: | 308.5 °C |
Solubility: | Soluble in water, alcohol, acetone and warm acetic acid. |
Appearance: | beige to yellowish powder |
Hazard Symbols: | Xi |
Risk Codes: | 22 |
Safety: | 22-24/25-36 |
PSA: | 225.06000 |
LogP: | -1.16520 |
4'-rhamnoglucosyloxy-2',4,6'-trihydroxychalcone
naringin
Conditions | Yield |
---|---|
With sodium hydroxide In ethanol; water at 25℃; Kinetics; Equilibrium constant; Activation energy; Further Variations:; Solvents; |
naringin
5,7-Dihydroxy-2-(4-hydroxy-phenyl)-chroman-4-on
Conditions | Yield |
---|---|
With sulfuric acid In water at 121℃; for 2h; | 100% |
naringin
acetic anhydride
Conditions | Yield |
---|---|
With pyridine; dmap at 20℃; for 2h; Inert atmosphere; | 99% |
With sodium acetate for 4h; Acetylation; Heating; |
naringin
[4-[[2-O-(6-deoxy-L-mannopyranosyl)-D-glucopyranosyl]oxy]-2,6-dihydroxyphenyl]-3-(4-hydroxyphenyl)-1-propanone
Conditions | Yield |
---|---|
With palladium on activated charcoal; hydrogen; potassium hydroxide In ethanol at 55℃; under 7500.75 - 15001.5 Torr; Temperature; Reagent/catalyst; Pressure; Autoclave; | 98% |
With potassium hydroxide; hydrogen; palladium on activated charcoal at 30℃; under 2280 Torr; for 0.5h; |
Conditions | Yield |
---|---|
In methanol; ethanol at 50℃; for 1.5h; | 87% |
naringin
2,6-dihydroxy-4-(β-neohesperidosyloxy)acetophenone
Conditions | Yield |
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With potassium hydroxide for 4h; Heating; | 64% |
naringin
prunin
Conditions | Yield |
---|---|
With sulfuric acid In water at 121℃; for 0.5h; High pressure; | 58% |
naringin
dimethyl sulfate
5-hydroxy-7-methoxy-2-(4-methoxyphenyl)-4H-chromen-4-one
Conditions | Yield |
---|---|
Stage #1: naringin With pyridine; iodine Heating; Stage #2: With sulfuric acid In ethanol Heating; Stage #3: dimethyl sulfate With potassium carbonate In acetone at 45℃; for 0.5h; regioselective reaction; | 44% |
naringin
A
D-Glucose
B
prunin
C
2-O-α-L-rhamonopyranosyl-D-glucopyranose
D
5,7-Dihydroxy-2-(4-hydroxy-phenyl)-chroman-4-on
Conditions | Yield |
---|---|
With water at 120℃; for 45h; | A 16 mg B 13 mg C 30 mg D 30 mg |
Conditions | Yield |
---|---|
With cyclodextrin glucanotransferase from alkanophilic Bacillus sp. AP A2-5a In water at 40℃; for 16h; other reagent; |
IUPAC Name: 7-[(2S,3R,4S,5S,6R)-4,5-Dihydroxy-6-(hydroxymethyl)-3-[(2S,3R,4R,5R,6S)-3,4,5-trihydroxy-6-methyloxan-2-yl]oxyoxan-2-yl]oxy-5-hydroxy-2-(4-hydroxyphenyl)-2,3-dihydrochromen-4-one
Synonyms of Naringin (CAS NO.10236-47-2): 5-Hydroxy-2-(4-hydroxyphenyl)-7-(2-O-alpha-L-rhamnopyranosyl-beta-D-glucopyranosyloxy)-4-chromanon ; Naringenin-7-beta-neohesperidoside ; Naringoside ; 4H-1-Benzopyran-4-one, 7-((2-O-(6-deoxy-alpha-L-mannapyranosyl)-beta-D-glucopyranosyl)oxy)-2,3-dihydro-5-hydroxy-2-(4-hydroxyphenyl), (S)- ; 4H-1-Benzopyran-4-one, 7-((2-O-(6-deoxy-alpha-L-mannopyranosyl)-beta-D-glucopyranosyl)oxy)-2,3-dihydro-5-hydroxy-2-(4-hydroxyphenyl)-, (2S)- ; 7-(2-O-(6-Deoxy-alpha-L-mannopyranosyl)-beta-D-glucopyranosyloxy)-2,3-dihydro-4',5,7-trihydroxyflavone
CAS NO: 10236-47-2
Molecular Formula: C27H32O14
Molecular Weight: 580.54
Molecular Structure:
H bond acceptors: 14
H bond donors: 8
Freely Rotating Bonds: 14
Polar Surface Area: 137.06 Å2
Index of Refraction: 1.708
Molar Refractivity: 135.63 cm3
Molar Volume: 347.8 cm3
Surface Tension: 101.2 dyne/cm
Density: 1.66 g/cm3
Flash Point: 308.5 °C
Enthalpy of Vaporization: 141.42 kJ/mol
Boiling Point: 928.1 °C at 760 mmHg
Vapour Pressure: 0 mmHg at 25°C
Melting Point: 166 °C
Alpha: -91 º (c=1, C2H5OH)
Storage temp: 0-6°C
Appearance: beige to yellowish powder
Product Categories of Naringin (CAS NO.10236-47-2): Flavanones;Biochemistry;Disaccharides;Flavonoids;Glycosides;Sugars;Natural Plant Extract
Naringin (CAS NO.10236-47-2) has obvious anti-inflammation effect. Besides it can reduce blood viscosity and thrombosis. Naringin can also be used for analgesia, calm, and increase the secretion of bile of the experimental animals.
Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
---|---|---|---|---|---|
guinea pig | LD50 | intraperitoneal | 2gm/kg (2000mg/kg) | Eksperimentalna Meditsina i Morfologiya. Vol. 19, Pg. 207, 1980. | |
rat | LD50 | intraperitoneal | 2gm/kg (2000mg/kg) | Eksperimentalna Meditsina i Morfologiya. Vol. 19, Pg. 207, 1980. |
Safety information of Naringin (CAS NO.10236-47-2):
Hazard Codes: Xn
Risk Statements: 22
R22: Harmful if swallowed.
Safety Statements: 22-24/25-36
S22: Do not breathe dust.
S24/25: Avoid contact with skin and eyes.
S36: Wear suitable protective clothing.
WGK Germany: 3
RTECS: QN6340000
F: 3
General Information: As in any fire, wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. During a fire, irritating and highly toxic gases may be generated by thermal decomposition or combustion.
Extinguishing Media: Use agent most appropriate to extinguish fire.
Handling: Avoid breathing dust, vapor, mist, or gas. Avoid contact with eyes, skin, and clothing.
Storage: Store in a cool, dry place. Store in a tightly closed container.