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CAS No.: | 10040-45-6 |
---|---|
Name: | Sodium picosulfate |
Molecular Structure: | |
Formula: | C18H13NNa2O8S2 |
Molecular Weight: | 481.415 |
Synonyms: | Phenol,4,4'-(2-pyridinylmethylene)bis-, bis(hydrogen sulfate) (ester), disodium salt(9CI);Phenol, 4,4'-(2-pyridylmethylene)di-, bis(hydrogen sulfate) (ester)disodium salt (8CI);4,4'-(2-Pyridylmethylene)diphenol bis(hydrogen sulfate)disodium salt;DA 1773;Disodium bis[4-[(hydroxysulfonyl)oxy]phenyl](2-pyridyl)methane;Evacuol;Guttalax;Guttalax-Fher;LA 391;Laxoberal;Laxoberon;Neopax;Pico-Salax;Picolax;Picosulfate sodium;Picosulfol;Rapilax;Sodiumpicosulfate; |
EINECS: | 233-120-9 |
Melting Point: | 272 - 275oC |
Appearance: | gray powder complex |
PSA: | 162.51000 |
LogP: | 4.10140 |
4,4'-(2-pyridylmethylene)diphenol
Guttalax
Conditions | Yield |
---|---|
Stage #1: 4,4'-(2-pyridylmethylene)diphenol With pyridine; chlorosulfonic acid at 0 - 20℃; for 5h; Stage #2: With sodium hydroxide Concentration; Cooling with ice; | 86.4% |
Stage #1: 4,4'-(2-pyridylmethylene)diphenol With pyridine; chlorosulfonic acid at 35 - 40℃; for 3h; Flow reactor; Stage #2: With sodium hydroxide | 59.9% |
Stage #1: 4,4'-(2-pyridylmethylene)diphenol With pyridine; chlorosulfonic acid at 10 - 25℃; for 12h; Inert atmosphere; Large scale; Stage #2: With water; sodium hydroxide at 0℃; pH=11; pH-value; Inert atmosphere; Large scale; | 2.1 kg |
1-bromo-4-methoxy-benzene
Guttalax
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1.1: magnesium / tetrahydrofuran / 1 h / 20 - 65 °C / Inert atmosphere; Large scale 1.2: 4 h / 10 - 20 °C / Inert atmosphere; Large scale 2.1: hydrogen iodide; acetic acid / 6 h / 100 °C / Large scale 3.1: pyridine; chlorosulfonic acid / 12 h / 10 - 25 °C / Inert atmosphere; Large scale 3.2: 0 °C / pH 11 / Inert atmosphere; Large scale View Scheme |
ethyl-2-picolinate
Guttalax
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1.1: magnesium / tetrahydrofuran / 1 h / 20 - 65 °C / Inert atmosphere; Large scale 1.2: 4 h / 10 - 20 °C / Inert atmosphere; Large scale 2.1: hydrogen iodide; acetic acid / 6 h / 100 °C / Large scale 3.1: pyridine; chlorosulfonic acid / 12 h / 10 - 25 °C / Inert atmosphere; Large scale 3.2: 0 °C / pH 11 / Inert atmosphere; Large scale View Scheme |
Conditions | Yield |
---|---|
In water at 25℃; |
Guttalax
4-((4-hydroxyphenyl)(pyridin-2-yl)methyl)phenyl hydrogen sulfate
Conditions | Yield |
---|---|
With water at 40℃; for 730.5h; Temperature; |
Guttalax
A
4-((4-hydroxyphenyl)(pyridin-2-yl)methyl)phenyl hydrogen sulfate
B
4,4'-(2-pyridylmethylene)diphenol
Conditions | Yield |
---|---|
With water at 40℃; for 730.5h; |
Guttalax
A
4-((4-hydroxyphenyl)(pyridin-2-yl)methyl)phenyl hydrogen sulfate
B
4,4'-(2-pyridylmethylene)diphenol
Conditions | Yield |
---|---|
With water at 40℃; for 4383h; Temperature; |
Guttalax
A
4-((4-hydroxyphenyl)(pyridin-2-yl)methyl)phenyl hydrogen sulfate
Conditions | Yield |
---|---|
With water at 40℃; for 2191.5h; pH=4.5; pH-value; Temperature; |
IUPAC Name: disodium [4-[Pyridin-2-yl-(4-sulfonatooxyphenyl)methyl]phenyl] sulfate
Canonical SMILES: C1=CC=NC(=C1)C(C2=CC=C(C=C2)OS(=O)(=O)[O-])C3=CC=C(C=C3)OS(=O)(=O)[O-].[Na+].[Na+]
InChI: InChI=1S/C18H15NO8S2.2Na/c20-28(21,22)26-15-8-4-13(5-9-15)18(17-3-1-2-12-19-17)14-6-10-16(11-7-14)27-29(23,24)25;;/h1-12,18H,(H,20,21,22)(H,23,24,25);;/q;2*+1/p-2
EINECS: 233-120-9
Empirical Formula: C18H13NNa2O8S2
Molecular Weight: 481.4073
Classification Code of Sodium picosulfate (CAS NO.10040-45-6): Cathartics; Drug / Therapeutic Agent; Gastrointestinal Agents; Reproductive Effect
Sodium picosulfate (CAS NO.10040-45-6) is a laxative and is generally used for emergency evacuation of the bowel, usually for patients who are preparing to undergo a colonoscopy. It is usually a lemon flavour and has to be dissolved into a glass of water. It works very quickly, so access to a toilet at all times is recommended. It starts off just by making your bowel movements looser and more frequent, but within an hour or so of taking it the patient should experience diarrhoea. The most common side effects of Sodium picosulfate are abdominal cramps and diarrhoea. The use of Sodium picosulfate has also been associated with certain electrolyte disturbances, such as hyponatremia and hypokalemia.
Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
---|---|---|---|---|---|
mouse | LD50 | intraperitoneal | 2900mg/kg (2900mg/kg) | BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD LUNGS, THORAX, OR RESPIRATION: RESPIRATORY STIMULATION | Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 8, Pg. 341, 1977. |
mouse | LD50 | intravenous | 1600mg/kg (1600mg/kg) | BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD LUNGS, THORAX, OR RESPIRATION: RESPIRATORY STIMULATION | Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 8, Pg. 341, 1977. |
mouse | LD50 | oral | 14500mg/kg (14500mg/kg) | BEHAVIORAL: ATAXIA GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA" SKIN AND APPENDAGES (SKIN): HAIR: OTHER | Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 8, Pg. 341, 1977. |
mouse | LD50 | subcutaneous | 6420mg/kg (6420mg/kg) | BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA" | Nara Igaku Zasshi. Journal of the Nara Medical Association. Vol. 28, Pg. 258, 1977. |
rat | LD50 | intraperitoneal | 3gm/kg (3000mg/kg) | BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD BEHAVIORAL: ATAXIA LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION | Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 8, Pg. 341, 1977. |
rat | LD50 | intravenous | 1450mg/kg (1450mg/kg) | BEHAVIORAL: ATAXIA | Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 8, Pg. 341, 1977. |
rat | LD50 | oral | 11300mg/kg (11300mg/kg) | Drugs in Japan Vol. -, Pg. 993, 1995. | |
rat | LD50 | subcutaneous | 6980mg/kg (6980mg/kg) | SENSE ORGANS AND SPECIAL SENSES: LACRIMATION: EYE BEHAVIORAL: COMA GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA" | Nara Igaku Zasshi. Journal of the Nara Medical Association. Vol. 28, Pg. 258, 1977. |
Sodium picosulfate (CAS NO.10040-45-6), its Synonyms are 2-Picolylidenebis(p-phenyl sodium sulfate) ; 4,4'-(2-Picolylidene)bis(phenylsulfuric acid) disodium salt ; 4,4'-(2-Pyridinylmethylene)bisphenol bis(hydrogen sulfate)(ester) disodium salt ; 4,4'-(2-Pyridylmethylene)diphenolbis(hydrogen sulfate) (ester) disodium salt ; DA-1773 ; Disodium 4,4'-disulfoxydiphenyl-(2-pyridyl)methane ; Picosulfate sodium ; Picosulfato sodico .