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Sophoridine

  • Name Sophoridine
  • EINECSN/A
  • CAS No. 83148-91-8
  • Density1.16 g/cm3
  • PSA23.55000
  • LogP1.74750
  • SolubilityN/A
  • Melting PointN/A
  • FormulaC15H24N2O
  • Boiling Point396.7 °C at 760 mmHg
  • Molecular Weight248.368
  • Flash Point172.7 °C
  • Transport InformationN/A
  • AppearanceN/A
  • Safety
  • Risk CodesN/A
  • Molecular Structure
    Molecular Structure of 83148-91-8 (Sophoridine)
  • Hazard SymbolsN/A
  • SynonymsN/A
  • Article Data2

Sophoridine Chemical Properties

 Sophoridine(83148-91-8) is also called for Sophoridin ; l-Sophoridine ; Matrine ; 5-Epidihydrosophocarpine ; Dihydro-5-episophocarpine ;  (5-beta)-Matridin-15-one ; (5beta)-Matridin-15-one ; Matridin-15-one, (5-beta)- (9CI) ; TL8004825 ; Bio-0637 and so on.
Molecular Formula: C15H24N2O
Molecular Weight: 248.36
Molar Volume: 213.3 cm3
Density: 1.16 g/cm3
Flash Point: 172.7°C   
Boiling Point: 396.7°C at 760 mmHg
LogP: ACD/LogP: 1.44
LogP: 1.40
ACD/LogD (pH 5.5): -1.59 
ACD/LogD (pH 7.4): -0.47 
ACD/BCF (pH 5.5): 1 
ACD/BCF (pH 7.4): 1 
ACD/KOC (pH 5.5): 1 
ACD/KOC (pH 7.4): 1.79 
H bond acceptors: 3 
H bond donors: 0 
Freely Rotating Bonds: 0   
Index of Refraction: 1.581 
Molar Refractivity: 71.12 cm  
Surface Tension: 48.3 dyne/cm   
Enthalpy of Vaporization: 64.71 kJ/mol  
The molecular structure of  Sophoridine(83148-91-8):

 

Sophoridine Uses

 Sophoridine(83148-91-8) is used as a pharmaceutical composition that has analgetic effects and sophoridine which is an alkaloid and is derived from sophora alopecuroides L. When the sophoridine or its derivates or its analogs are used as analgesics, in addition to antitumor activity and analgetic effects of biquinolizidines compounds, they will have an advantage of not refraining from them after long term application.

Sophoridine Toxicity Data With Reference

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LD50 intraperitoneal 64300ug/kg (64.3mg/kg)   Zhongguo Yaoli Xuebao. Acta Pharmacologica Sinica. Chinese Journal of Pharmacology. Vol. 8, Pg. 153, 1987.
mouse LD50 intravenous 46800ug/kg (46.8mg/kg)   Yaowu Fenxi Zazhi. Journal of Pharmaceutical Analysis. Vol. 6, Pg. 96, 1986.
mouse LD50 oral 243mg/kg (243mg/kg)   Zhongguo Yaoxue Zazhi. Chinese Pharmacuetical Journal. Vol. 27, Pg. 201, 1992.

Sophoridine Specification

Treatment of Sophoridine(83148-91-8) in Wastewater, see as follows:
Total removal:                  2.05  percent
Total biodegradation:        0.09  percent
Total sludge adsorption:    1.96  percent
Total to Air:                      0.00  percent
(using 10000 hr Bio P,A,S)

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