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Conditions | Yield |
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In water | |
In water |
Conditions | Yield |
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In water |
L-Phenylalaninol
(R)-(-)-deprenyl hydrochloride
Conditions | Yield |
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Multi-step reaction with 5 steps 1.1: sulfuric acid / toluene / 0.5 h / 20 °C 1.2: 20 h / 80 °C 2.1: ammonium hydroxide / 3 h / 30 - 35 °C 3.1: sodium bis(2-methoxyethoxy)aluminium dihydride / toluene / 5 h / 80 - 85 °C 3.2: 1 h / 25 - 30 °C 4.1: methanol / 3 h / 0 - 10 °C 4.2: 3 h / 0 - 10 °C 4.3: 0 - 10 °C / pH 4-6 5.1: hydrogenchloride / isopropyl alcohol / 2 h / 20 °C View Scheme |
L-phenylalanine
(R)-(-)-deprenyl hydrochloride
Conditions | Yield |
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Multi-step reaction with 6 steps 1.1: sodium tetrahydroborate / 1,4-dioxane / 0.5 h / 20 °C 1.2: 20 h / 20 °C 2.1: sulfuric acid / toluene / 0.5 h / 20 °C 2.2: 20 h / 80 °C 3.1: ammonium hydroxide / 3 h / 30 - 35 °C 4.1: sodium bis(2-methoxyethoxy)aluminium dihydride / toluene / 5 h / 80 - 85 °C 4.2: 1 h / 25 - 30 °C 5.1: methanol / 3 h / 0 - 10 °C 5.2: 3 h / 0 - 10 °C 5.3: 0 - 10 °C / pH 4-6 6.1: hydrogenchloride / isopropyl alcohol / 2 h / 20 °C View Scheme |
(2S)-2-benzylazacyclopropane
(R)-(-)-deprenyl hydrochloride
Conditions | Yield |
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Multi-step reaction with 4 steps 1.1: ammonium hydroxide / 3 h / 30 - 35 °C 2.1: sodium bis(2-methoxyethoxy)aluminium dihydride / toluene / 5 h / 80 - 85 °C 2.2: 1 h / 25 - 30 °C 3.1: methanol / 3 h / 0 - 10 °C 3.2: 3 h / 0 - 10 °C 3.3: 0 - 10 °C / pH 4-6 4.1: hydrogenchloride / isopropyl alcohol / 2 h / 20 °C View Scheme |
(R)-(-)-deprenyl hydrochloride
Conditions | Yield |
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Multi-step reaction with 3 steps 1.1: sodium bis(2-methoxyethoxy)aluminium dihydride / toluene / 5 h / 80 - 85 °C 1.2: 1 h / 25 - 30 °C 2.1: methanol / 3 h / 0 - 10 °C 2.2: 3 h / 0 - 10 °C 2.3: 0 - 10 °C / pH 4-6 3.1: hydrogenchloride / isopropyl alcohol / 2 h / 20 °C View Scheme |
(R)-(-)-deprenyl hydrochloride
Conditions | Yield |
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With hydrogenchloride In isopropyl alcohol at 20℃; for 2h; | 145 g |
(R)-(-)-deprenyl hydrochloride
Conditions | Yield |
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With sodium carbonate for 1h; | 100% |
(R)-(-)-deprenyl hydrochloride
toluene
Conditions | Yield |
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With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; triethylamine In tetrahydrofuran at 23℃; for 16h; Sonogashira Cross-Coupling; Schlenk technique; Inert atmosphere; | 84% |
(R)-(-)-deprenyl hydrochloride
(R)-2-N-methylamino-1-phenylpropane hydrochloride
Conditions | Yield |
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With phosphate buffer at 105℃; Thermodynamic data; Rate constant; Kinetics; ΔE(excit.); other reagent; other temperature; |
Selegiline hydrochloride, with CAS number of 14611-52-0, can be called Benzeneethanamine,N,a-dimethyl-N-2-propynyl-,hydrochloride, (R)-; Benzeneethanamine, N,a-dimethyl-N-2-propynyl-, hydrochloride, (aR)- (9CI); (-)-Deprenilhydrochloride; (-)-Deprenyl hydrochloride; l-Deprenyl hydrochloride; Selegilinehydrochloride; R-Selegiline hydrochloride. Selegiline hydrochloride is a levorotatory acetylenic derivative of phenethylamine. It is commonly referred to in the clinical and pharmacological literature as l-deprenyl. It is used in newly diagnosed patients with Parkinson's disease.
Physical properties about Selegiline hydrochloride are: (1)ACD/LogP: 2.954; (2)ACD/LogD (pH 5.5): 0.95; (3)ACD/LogD (pH 7.4): 2.58; (4)ACD/BCF (pH 5.5): 1.03; (5)ACD/BCF (pH 7.4): 43.99; (6)ACD/KOC (pH 5.5): 9.62; (7)ACD/KOC (pH 7.4): 409.51; (8)#H bond acceptors: 1; (9)#Freely Rotating Bonds: 4; (10)Flash Point: 108.4 °C; (11)Enthalpy of Vaporization: 51.08 kJ/mol; (12)Boiling Point: 272.5 °C at 760 mmHg; (13)Vapour Pressure: 0.00606 mmHg at 25°C
You can still convert the following datas into molecular structure:
(1)InChI=1S/C13H17N.ClH/c1-4-10-14(3)12(2)11-13-8-6-5-7-9-13;/h1,5-9,12H,10-11H2,2-3H3;1H/t12-;/m1./s1;
(2)InChIKey=IYETZZCWLLUHIJ-UTONKHPSSA-N;
(3)SmilesCl.c1(C[C@H](N(CC#C)C)C)ccccc1
The toxicity data is as follows:
Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
---|---|---|---|---|---|
mouse | LD50 | unreported | 121mg/kg (121mg/kg) | Acta Physiologica Academiae Scientiarum Hungaricae. Vol. 32, Pg. 377, 1967. | |
rat | LD50 | intravenous | 81mg/kg (81mg/kg) | Acta Physiologica Academiae Scientiarum Hungaricae. Vol. 32, Pg. 377, 1967. | |
rat | LD50 | subcutaneous | 280mg/kg (280mg/kg) | Acta Physiologica Academiae Scientiarum Hungaricae. Vol. 32, Pg. 377, 1967. |