Technology Process of 2-(4-iodo-1H-indol-3-yl)acetic acid
There total 15 articles about 2-(4-iodo-1H-indol-3-yl)acetic acid which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
sodium hydroxide;
In
methanol;
for 2h;
Heating;
DOI:10.1248/cpb.33.3696
- Guidance literature:
-
With
sodium hydroxide;
In
methanol;
for 2h;
Heating;
DOI:10.1248/cpb.33.3696
- Guidance literature:
-
Multi-step reaction with 7 steps
1: 82.5 percent / H2O; aq. acetic acid / 12 h / Ambient temperature
2: 55.9 percent / H2O; dimethylformamide / 1.5 h / Heating
3: 86.2 percent / 50percent NaH / dimethylformamide; benzene / 1.) room temp., 15 min; 2.) room temp., 10 h
4: 77.6 percent / TiCl3 / tetrahydrofuran / 0.33 h / Ambient temperature
5: NaNO2/2 N HCl
6: KI / aq. HCl / 1.) room temp., 1 h; 2.) 95 deg C, 5 min
7: 66.5 percent / 40percent aq. NaOH / methanol / 2 h / Heating
With
hydrogenchloride; sodium hydroxide; titanium(III) chloride; sodium hydride; potassium iodide; sodium nitrite;
In
tetrahydrofuran; hydrogenchloride; methanol; water; acetic acid; N,N-dimethyl-formamide; benzene;
DOI:10.1248/cpb.33.3696