4769-97-5Relevant articles and documents
Synthesis of model chromophores related to the gold fluorescent protein (GdFP)
Prueger, Birgit,Bach, Thorsten
, p. 1103 - 1106 (2007)
The two model chromophores 2 and 3 for the core 1 of the gold fluorescent protein (GdFP) were synthesized from commercially available 2-methyl-3- nitroaniline (4) in six synthetic steps and overall yields of 13% and 8%, respectively. The key step of the sequence is the chemoselective, reductive introduction of the amino group after assembly of the Z-configured 5-(indol-3-ylmethylene)imidazolin-4-one skeleton of the chromophore. Compound (Z)-2 was shown to undergo a light-initiated E/Z-isomerization, which allows access also to its E-isomer. Georg Thieme Verlag Stuttgart.
A medicine intermediate 4 - nitro indole preparation process (by machine translation)
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Paragraph 0026; 0028; 0029; 0030-0032; 0034-0036; 0038, (2019/06/13)
The present invention discloses a pharmaceutical intermediate 4 - nitro indole preparation process, which belongs to the field of pharmaceutical intermediates. The invention relates to 2 - methyl - 3 - nitroaniline with the original carboxylic acid triethyl ester as raw material, in the sulfonic acid type cation exchange resin and common under the catalysis of the sodium tartrate, for 95 - 105 °C lower, reaction generating N - (2 - methyl - 3 - nitrophenyl) b [...] imine, N - (2 - methyl - 3 - nitrophenyl) b oxygen radical armor imine with strong alkali and diethyl oxalate phosphite to produce 4 - nitro indole. The invention two-step process of 4 - nitro indole, intermediate does not need purification, simplifies the process, and avoiding the loss of the product; at the same time the process of the invention, simple post-treatment, the product has high purity, the purification process of product loss, high yield. (by machine translation)
Preparation method of pharmaceutical intermediate (4-nitroindole)
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Page/Page column 4; 5; 6, (2019/01/14)
The invention discloses a preparation method of a pharmaceutical intermediate (4-nitroindole). The preparation method specifically comprises the following steps of firstly, using para-methylbenzenesulfonic acid, citric acid and cerium nitrate as raw materials, and reacting with an alkaline solution, so as to obtain a rare earth cerium-coordinated complex containing para-methylbenzenesulfonic acidand citric acid; using the rare earth cerium-coordinated complex as a catalyst to catalyze 2-methyl-3-nitroaniline and triethyl orthoformate to react, so as to obtain N-(2-methyl-3-nitrobenzo)ethoxymethylamine, and mixing with diethyl oxalate and potassium acetate, so as to obtain a target product. The preparation method has the advantages that the reaction conditions are mild; the yield rate of the prepared product is high.