1-[2-(Benzyloxy)-5-bromophenyl]adamantane

Base Information

• Chemical Name: 1-[2-(Benzyloxy)-5-bromophenyl]adamantane
• CAS No.: 736992-49-7
• Molecular Formula: C23H25BrO
• Molecular Weight: 397.355
• Hs Code.: 2909309090
• Mol file: 736992-49-7.mol

Synonyms:1-(2-benzyloxy-5-bromo-phenyl)adamantane;1-[2-(Benzyloxy)-5-bromophenyl]adamantane 98%;2-(Adamantan-1-yl)-1-benzyloxy-4-bromobenzene;

Chemical Property of 1-[2-(Benzyloxy)-5-bromophenyl]adamantane

Chemical Property:

• Vapor Pressure: 1.24E-09mmHg at 25°C
• Refractive Index: 1.622
• Boiling Point: 499.8 °C at 760 mmHg
• Flash Point: 192.4 °C
• PSA: 9.23000
• Density: 1.327 g/cm³
• LogP: 6.49590

Purity/Quality:

98%Min ^*data from raw suppliers

2-Adamantyl-1-benzyloxy-4-bromobenzene ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1-[2-(Benzyloxy)-5-bromophenyl]adamantane

There total 3 articles about 1-[2-(Benzyloxy)-5-bromophenyl]adamantane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4-bromo-phenol (106-41-2) → 2-(1-adamantyl)-1-benzyloxy-4-bromobenzene (736992-49-7)

Guidance literature:

Multi-step reaction with 2 steps

1: conc. sulfuric acid / CH₂Cl₂

2: K₂CO₃ / acetone / Heating

With potassium carbonate; sulfuric acid; In dichloromethane; acetone; 1: Friedel-Crafts alkylation;

DOI:10.1021/jm0613323

Reference yield:

1-adamanthanol (768-95-6) → 2-(1-adamantyl)-1-benzyloxy-4-bromobenzene (736992-49-7)

Guidance literature:

Multi-step reaction with 2 steps

1: conc. sulfuric acid / CH₂Cl₂

2: K₂CO₃ / acetone / Heating

With potassium carbonate; sulfuric acid; In dichloromethane; acetone; 1: Friedel-Crafts alkylation;

DOI:10.1021/jm0613323

Reference yield:

benzyl bromide (100-39-0) + 2-(1-adamantyl)-4-bromophenol (104224-68-2) → 2-(1-adamantyl)-1-benzyloxy-4-bromobenzene (736992-49-7)

Guidance literature:

With potassium carbonate; In acetone; Heating;

DOI:10.1021/jm0613323

upstream raw materials:

benzyl bromide

2-(1-adamantyl)-4-bromophenol

4-bromo-phenol

1-adamanthanol

Downstream raw materials:

3-(1-adamantyl)-4-benzyloxyphenylboronic acid

(E)-4-[3'-(1-adamantyl)-4'-benzyloxyphenyl]-3-chlorocinnamonitrile

(E)-4-[3'-(1-adamantyl)-4'-hydroxyphenyl]-3-chlorocinnamonitrile

4-[3'-(1-adamantyl)-4'-benzyloxyphenyl]-3-chlorobenzonitrile

Refernces