Technology Process of 4-[3'-(1-adamantyl)-4'-benzyloxyphenyl]-3-chlorobenzonitrile
There total 10 articles about 4-[3'-(1-adamantyl)-4'-benzyloxyphenyl]-3-chlorobenzonitrile which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
sodium carbonate; lithium chloride;
tetrakis(triphenylphosphine) palladium(0);
In
1,2-dimethoxyethane;
for 24h;
Heating;
DOI:10.1021/jm0613323
- Guidance literature:
-
Multi-step reaction with 4 steps
1: 91 percent / pyridine; methanesulfonyl chloride / toluene / 3 h / Heating
2: 88 percent / BBr3 / CH2Cl2 / 2 h / -78 °C
3: 530 mg / pyridine / CH2Cl2 / 20 °C
4: 57 percent / LiCl; aq. Na2CO3 / tetrakis(triphenylphosphine)palladium / 1,2-dimethoxy-ethane / 24 h / Heating
With
pyridine; boron tribromide; sodium carbonate; methanesulfonyl chloride; lithium chloride;
tetrakis(triphenylphosphine) palladium(0);
In
1,2-dimethoxyethane; dichloromethane; toluene;
4: Suzuki-Miyaura coupling;
DOI:10.1021/jm0613323
- Guidance literature:
-
Multi-step reaction with 3 steps
1: 88 percent / BBr3 / CH2Cl2 / 2 h / -78 °C
2: 530 mg / pyridine / CH2Cl2 / 20 °C
3: 57 percent / LiCl; aq. Na2CO3 / tetrakis(triphenylphosphine)palladium / 1,2-dimethoxy-ethane / 24 h / Heating
With
pyridine; boron tribromide; sodium carbonate; lithium chloride;
tetrakis(triphenylphosphine) palladium(0);
In
1,2-dimethoxyethane; dichloromethane;
3: Suzuki-Miyaura coupling;
DOI:10.1021/jm0613323
