N-METHYL-3,4,5-TRIMETHOXYBENZYLAMINE

Base Information

• Chemical Name: N-METHYL-3,4,5-TRIMETHOXYBENZYLAMINE
• CAS No.: 58780-82-8
• Molecular Formula: C11H17NO3
• Molecular Weight: 211.261
• Hs Code.: 2922299090
• Mol file: 58780-82-8.mol

Synonyms:Benzylamine,3,4,5-trimethoxy-N-methyl- (6CI);N-Methyl-3,4,5-trimethoxybenzylamine;N-Methyl-N-[(3,4,5-trimethoxyphenyl)methyl]amine;

Chemical Property of N-METHYL-3,4,5-TRIMETHOXYBENZYLAMINE

Chemical Property:

• Vapor Pressure: 0.00213mmHg at 25°C
• Boiling Point: 289.9 °C at 760 mmHg
• PKA: 9.01±0.10(Predicted)
• Flash Point: 119.1 °C
• PSA: 39.72000
• Density: 1.04 g/cm³
• LogP: 1.82270
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C

Purity/Quality:

98%,99%, ^*data from raw suppliers

N-(3-Oxopropyl)acetamide AldrichCPR ^*data from reagent suppliers

Safty Information:

• Statements: 36/37/38
• Safety Statements: 26-36/37/39

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of N-METHYL-3,4,5-TRIMETHOXYBENZYLAMINE

There total 3 articles about N-METHYL-3,4,5-TRIMETHOXYBENZYLAMINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

3,4,5-trimethoxy-benzaldehyde (86-81-7) + methylamine (74-89-5) → N-methyl-1-(3,4,5-trimethoxyphenyl)methanamine (58780-82-8)

Guidance literature:

With hydrogen; platinum on activated charcoal; In methanol; water;

DOI:10.1021/jm00134a003

Reference yield:

N-methyl-3,4,5-trimethoxybenzamide (55100-33-9) → N-methyl-1-(3,4,5-trimethoxyphenyl)methanamine (58780-82-8)

Guidance literature:

With hydrogenchloride; sodium hydroxide; In tetrahydrofuran;

Reference yield:

→ N-methyl-1-(3,4,5-trimethoxyphenyl)methanamine (58780-82-8)

Guidance literature:

With ethanol; palladium; Hydrogenation_.unter geringem Ueberdruck;

upstream raw materials:

3,4,5-trimethoxy-benzaldehyde

methylamine

N-methyl-3,4,5-trimethoxybenzamide

Downstream raw materials:

N⁶-Methyl-N⁶-(3,4,5-trimethoxy-benzyl)-pteridine-2,4,6-triamine

C₂₅H₃₃N₇O₅S

C₂₇H₃₇N₇O₅S

Refernces

• 1、 Park, Sun You,Oh, Yong Jin,Lho, Yunmee,Jeong, Ju Hui,Liu, Kwang-Hyeon,Song, Jaeyoung,Kim, Soong-Hyun,Ha, Eunyoung,Seo, Young Ho. "Design, synthesis, and biological evaluation of a series of resorcinol-based N-benzyl benzamide derivatives as potent Hsp90 inhibitors". . p. 390 - 401. Retrieved 2017/12/07.
• 2、 -. "Substituted alkyldiamine derivatives". . . Retrieved 2008/06/13.