55100-33-9

Basic information

• Product Name: 3,4,5-TRIMETHOXY-N-METHYLBENZAMIDE
• Synonyms: 3,4,5-TRIMETHOXY-N-METHYLBENZAMIDE;N-METHYL-3,4,5-TRIMETHOXYBENZAMIDE
• CAS NO: 55100-33-9
• Molecular Formula: C₁₁H₁₅NO₄
• Molecular Weight: 225.24
• Mol File: 55100-33-9.mol
• Article Data: 12

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 3,4,5-TRIMETHOXY-N-METHYLBENZAMIDE(CAS DataBase Reference)
• NIST Chemistry Reference: 3,4,5-TRIMETHOXY-N-METHYLBENZAMIDE(55100-33-9)
• EPA Substance Registry System: 3,4,5-TRIMETHOXY-N-METHYLBENZAMIDE(55100-33-9)

Safety Data

• Hazardous Substances Data: 55100-33-9(Hazardous Substances Data)

Usage

Description

3,4,5-trimethoxy-N-methylbenzamide is a chemical compound with the molecular formula C12H17NO4. It is a derivative of benzamide, with three methoxy groups and a methyl group attached to the nitrogen atom. 3,4,5-trimethoxy-N-methylbenzamide is commonly used in medicinal chemistry and pharmaceutical research as a potential drug candidate for various therapeutic applications. The methoxy groups and the amide functionality in its molecular structure contribute to its potential pharmacological properties, making it an interesting compound for further investigation and development. Additionally, it may possess unique biological activities that could be beneficial for the treatment of certain diseases or medical conditions.

Uses

Used in Pharmaceutical Research:
3,4,5-trimethoxy-N-methylbenzamide is used as a potential drug candidate for various therapeutic applications in pharmaceutical research. Its unique molecular structure with methoxy and amide groups contributes to its potential pharmacological properties, making it a promising compound for the development of new drugs.
Used in Medicinal Chemistry:
3,4,5-trimethoxy-N-methylbenzamide is used in medicinal chemistry for the investigation and development of its potential biological activities. Its unique molecular structure may offer insights into the treatment of certain diseases or medical conditions, providing a valuable resource for the discovery of new therapeutic agents.

Upstream product

• 82463-70-5 2-bromo-3,4,5-trimethoxy-N-methylbenzamide 
• 67-64-1 acetone 
• 74-89-5 methylamine 
• 118-41-2 Eudesmic acid 
• 421-20-5 Methyl fluorosulfonate 
• 1885-35-4 3,4,5-trimethoxybenzonitrile 
• 4521-61-3 3,4,5-Trimethoxybenzoyl chloride 
• 23346-82-9 2-bromo-3,4,5-trimethoxybenzoic acid 
• 80-43-3 bis(1-methyl-1-phenylethyl)peroxide 
• 3086-62-2 3,4,5-trimethoxybenzamide 
• 67-56-1 methanol 
• 39201-89-3 3,4,5-trimethoxybenzaldehyde oxime 

Downstream Products

• 86-81-7 3,4,5-trimethoxy-benzaldehyde 
• 18638-99-8 3,4,5-trimethoxybenzylamine 
• 82791-57-9 6,7-Dimethoxy-2-methyl-1-(3,4,5-trimethoxy-phenyl)-2H-isoquinolin-3-one 
• 82463-70-5 2-bromo-3,4,5-trimethoxy-N-methylbenzamide 
• 58780-82-8 N-methyl-1-(3,4,5-trimethoxyphenyl)methanamine 

Relevant articles and documents

Rhodium-Catalyzed Electrooxidative C?H Olefination of Benzamides

Metal-catalyzed chelation-assisted C?H olefinations have emerged as powerful tools for the construction of functionalized alkenes. Herein, we describe the rhoda-electrocatalyzed C?H activation/alkenylation of arenes. The olefinations of challenging electron-poor benzamides were thus accomplished in a fully dehydrogenative fashion under electrochemical conditions, avoiding stoichiometric chemical oxidants, and with H2 as the only byproduct. This versatile alkenylation reaction also features broad substrate scope and used electricity as a green oxidant.

Atom-Economical and Tandem Conversion of Nitriles to N-Methylated Amides Using Methanol and Water

A cobalt complex catalyzed tandem conversion of nitrile to N-methylated amide is described using a methanol and water mixture. Using this protocol, several nitriles were directly and efficiently converted to the desired N-methylated amides. Kinetic experiments using H2O18 and CD3OD suggested that water and methanol were the source of the oxygen atom and methyl group, respectively, in the final N-methylated amides. Importantly, the participation of active Co(I)-H species in this transformation was realized from the control experiment. The kinetic isotope effect (KIE) study suggested that the activation of the C-H bond of methanol was a kinetically important step. The Hammett plot confirmed that the reaction was faster with the electron deficient nitriles. In addition, the plausible pathway for the formation of N-methylated amides from the nitriles was supported by the computational study.

Chemoselective Synthesis of Aryl Ketones from Amides and Grignard Reagents via C(O)-N Bond Cleavage under Catalyst-Free Conditions

Conversion of a wide range of N-Boc amides to aryl ketones was achieved with Grignard reagents via chemoselective C(O)-N bond cleavage. The reactions proceeded under catalyst-free conditions with different aryl, alkyl, and alkynyl Grignard reagents. α-Ketoamide was successfully converted to aryl diketones, while α,β-unsaturated amide underwent 1,4-addition followed by C(O)-N bond cleavage to provide diaryl propiophenones. N-Boc amides displayed higher reactivity than Weinreb amides with Grignard reagents. A broad substrate scope, excellent yields, and quick conversion are important features of this methodology.