L-norvaline

Base Information

• Chemical Name: L-norvaline
• CAS No.: 6600-40-4
• Molecular Formula: C5H11NO2
• Molecular Weight: 117.148
• Hs Code.: 29224995
• Mol file: 6600-40-4.mol

Synonyms:L-Norvaline (9CI);Norvaline, L-;L-2-Aminovaleric acid;L-2-aminopentanoate;(S)-2-Aminopentanoic acid;L-(+)-2-aminovaleric acid;L-2-aminopentanoic acid;(2S)-2-aminopentanoic acid;alpha-L-Aminopentanoic acid;Leucine,2-methyl-;Pentanoic acid, 2-amino-, (S)-;L-Norvaaline;L(+)-Norvaline;(S)-2-Amino-pentanoic acid;

Chemical Property of L-norvaline

Chemical Property:

• Appearance/Colour: white to light yellow crystal powder
• Vapor Pressure: 0.0366mmHg at 25°C
• Melting Point: >300 °C(lit.)
• Refractive Index: 25 ° (C=10, 6mol/L HCl)
• Boiling Point: 222.9 °C at 760 mmHg
• PKA: 2.32(at 25℃)
• Flash Point: 88.6 °C
• PSA: 63.32000
• Density: 1.067 g/cm³
• LogP: 0.89870
• Storage Temp.: Store at RT.
• Solubility.: 48.7g/l
• Water Solubility.: 10.5 g/100 mL (18 ºC)
• XLogP3: -1.5
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 2
• Exact Mass: 117.078978594
• Heavy Atom Count: 8
• Complexity: 77

Purity/Quality:

HPLC≥98% ^*data from raw suppliers

L-Norvaline, 99% ^*data from reagent suppliers

Safty Information:

• Pictogram(s): C, Xn
• Hazard Codes: C,Xn
• Statements: 20/21/22-36/37/38
• Safety Statements: 24/25-37/39-26

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CCCC(C(=O)[O-])[NH3+]
• Isomeric SMILES: CCC[C@@H](C(=O)[O-])[NH3+]
• Description: L-Norvaline, an amino acid nutritional supplements, is a nonessential amino acid that’s typically found in protein-rich foods, such as meat and eggs. And, it can also be made by the body from valine during normal metabolism. L-norvaline is frequently consumed by athletes as part of their workout supplement program. It is usually used for pre-workout drinks to boost energy and support post-workout recovery. During workouts, L-norvaline improves muscle tissue strength and endurance by providing massive amounts of oxygen and nutrients.
• Uses: L-Norvaline is a protein amino acid used as a skin-conditioning and anti-static agent. It is also used in method for reducing misincorporation of non-canonical branched-chain Amino Acids into recombinant proteins.

Technology Process of L-norvaline

There total 75 articles about L-norvaline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

(3S,5S,6R)-4-(benzyloxycarbonyl)-5,6-diphenyl-3-(2'-propenyl)-2,3,5,6-tetrahydro-4H-1,4-oxazin-2-one (100516-55-0) → L-Norvaline (6600-40-4,498-18-0)

Guidance literature:

With hydrogen; palladium dichloride; In tetrahydrofuran; ethanol; for 21h; under 2068.6 Torr;

DOI:10.1021/ja00213a031

Reference yield: 92.0%

(1S,2S,5S,9S)-2,10,10-Trimethyl-5-propyl-3-oxa-6-aza-tricyclo[7.1.1.02,7]undec-6-en-4-one (141895-39-8) → L-Norvaline (6600-40-4,498-18-0)

Guidance literature:

With hydrogenchloride; In tetrahydrofuran; at 70 ℃; for 3h;

DOI:10.1016/S0957-4166(00)80263-3

Reference yield: 84.1%

2-oxopentanoic acid (1821-02-9) → L-Norvaline (6600-40-4,498-18-0)

Guidance literature:

With sodium formate; ammonium chloride; NADH; In aq. phosphate buffer; at 25 ℃; for 6h; pH=8.0; Reagent/catalyst; Kinetics; Green chemistry; Enzymatic reaction;

DOI:10.1002/cbic.201700493

upstream raw materials:

N-formyl-D,L-norvaline

N-formyl-L-norvaline

N-acetylnorvaline

N-Chloroacetyl norvaline

Downstream raw materials:

(S)-2-(1,3-dioxoisoindolin-2-yl)pentanoic acid

N-Acetyl-L-2-aminopentanoic acid

N-(2,4-dinitro-phenyl)-L-norvaline

N-tert-butoxycarbonyl-L-norvaline

Refernces

• 1、 Liu, Yayun,Meng, Lijun,Wu, Jianping,Yang, Lirong,Yin, Xinjian,Zhou, Haisheng. "Semi-rational hinge engineering: modulating the conformational transformation of glutamate dehydrogenase for enhanced reductive amination activity towards non-natural substrates". . p. 3376 - 3386. Retrieved 2020/06/09.
• 2、 Kim, Hong-Gon,Han, Sang-Woo,Shin, Jong-Shik. "Combinatorial Mutation Analysis of ω-Transaminase to Create an Engineered Variant Capable of Asymmetric Amination of Isobutyrophenone". . p. 2594 - 2606. Retrieved 2019/05/15.