Profenamine

Base Information

• Chemical Name: Profenamine
• CAS No.: 522-00-9
• Molecular Formula: C₁₉H₂₄N₂S
• Molecular Weight: 312.479
• European Community (EC) Number: 208-320-4
• UNII: 7WI4P02YN1
• DSSTox Substance ID: DTXSID2023018
• Nikkaji Number: J2.060E
• Wikipedia: Profenamine
• Wikidata: Q7247908
• NCI Thesaurus Code: C73333
• Pharos Ligand ID: Q3RG8ZDFVVMX
• Metabolomics Workbench ID: 145134
• ChEMBL ID: CHEMBL1206
• Mol file: 522-00-9.mol

Synonyms:ethopropazine;ethopropazine hydrochloride;Lysivane;Parsidol;Parsitan;profenamine;profenamine hydrochloride

Chemical Property of Profenamine

Chemical Property:

• Melting Point: 53-55°
• Refractive Index: 1.5800 (estimate)
• Boiling Point: 430.1°Cat760mmHg
• Flash Point: 213.9°C
• PSA: 31.78000
• Density: 1.098g/cm³
• LogP: 5.08460
• Storage Temp.: -20°C
• XLogP3: 4.8
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 5
• Exact Mass: 312.16601995
• Heavy Atom Count: 22
• Complexity: 322

Purity/Quality:

98%min ^*data from raw suppliers

Parkin ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Canonical SMILES: CCN(CC)C(C)CN1C2=CC=CC=C2SC3=CC=CC=C31
• Uses: antiparkinsonian, anticholinergic

Technology Process of Profenamine

There total 10 articles about Profenamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

ethopropazine hydrochloride (1094-08-2,811411-33-3,811411-34-4) → 10-(2-diethylaminopropyl)phenothiazine (522-00-9,115016-99-4,115017-00-0)

Guidance literature:

With sodium hydroxide; In dichloromethane; Purification / work up;

Reference yield:

10H-phenothiazine (92-84-2) + 1-diethylamino-2-chloropropane (761-21-7) → Profenamin (103649-51-0) + 10-(2-diethylaminopropyl)phenothiazine (522-00-9,115016-99-4,115017-00-0)

Guidance literature:

racemat;

Reference yield:

methyl magnesium iodide (917-64-6) + diphenylamine (122-39-4) → Profenamin (103649-51-0) + 10-(2-diethylaminopropyl)phenothiazine (522-00-9,115016-99-4,115017-00-0)

Guidance literature:

With diethyl ether; 1-diethylamino-2-chloropropane; benzene; racemat; Erhitzen des Reaktionsprodukts mit Schwefel unter Zusatz von Jod;

upstream raw materials:

10H-phenothiazine

1-diethylamino-2-chloropropane

methyl magnesium iodide

diphenylamine

Downstream raw materials:

ethopropazine cation radical

Refernces

• 1、 Helle, N.,Kurreck, H.,Bock, M.,Kieslich, W.. "Endor Studies of Cation Radicals from Pharmacologically Active Phenothiazines". . p. 964 - 970. Retrieved 2007/10/02.