N-Methyl-tert-butylamine

Base Information

• Chemical Name: N-Methyl-tert-butylamine
• CAS No.: 14610-37-8
• Molecular Formula: C5H13N
• Molecular Weight: 87.1649
• Hs Code.: 29211990
• European Community (EC) Number: 238-646-2
• DSSTox Substance ID: DTXSID70163272
• Nikkaji Number: J241.324H
• Wikidata: Q83032156
• Mol file: 14610-37-8.mol

Synonyms:N-Methyl-tert-butylamine;14610-37-8;N-tert-Butylmethylamine;2-Propanamine, N,2-dimethyl-;N,2-dimethylpropan-2-amine;tert-butyl(methyl)amine;tert-butylmethylamine;EINECS 238-646-2;MFCD00042853;N-Methyl-tert.-Butylamine;t-butylmethylamine;methyl-t-butylamine;N-t-butylmethylamine;N-methyl-t-butylamine;tert-butyl methylamine;tert-butyl-methylamine;methyl tert-butyl amine;N-tert Butylmethylamine;n-tert-butyl methylamine;N-tert-butyl-methylamine;N-methyl-N-tertbutylamine;N-tert-butyl methyl amine;N-methyl-N-tert-butylamine;N,2-Dimethyl-2-propanamine;N-tert-butyl-N-methyl amine;2-Propanamine,N,2-dimethyl-;N-tert-Butylmethylamine, 97%;Ethylamine, N,1,1-trimethyl-;N,2-Dimethyl-2-propanamine #;DTXSID70163272;N-Methyl-2-methyl-2-propanamine;BCP21403;GEO-01792;AKOS000258520;GS-0665;BB 0218187;D94509;EN300-121201;J-660042;Propanoic acid,3-[[2-[(4-azido-2,3,5,6-tetrafluorobenzoyl)amino]ethyl]dithio]-,2,5-dioxo-3-sulfo-1-pyrrolidinyl ester, sodium salt (1:1)

Chemical Property of N-Methyl-tert-butylamine

Chemical Property:

• Appearance/Colour: clear colorless liquid
• Vapor Pressure: 154mmHg at 25°C
• Melting Point: -75°C (estimate)
• Refractive Index: n20/D 1.395(lit.)
• Boiling Point: 66 °C at 760 mmHg
• PKA: 10.76±0.20(Predicted)
• Flash Point: −15 °F
• PSA: 12.03000
• Density: 0.726 g/cm³
• LogP: 1.39520
• Storage Temp.: Flammables area
• Sensitive.: Air Sensitive
• XLogP3: 0.8
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 1
• Exact Mass: 87.104799419
• Heavy Atom Count: 6
• Complexity: 33.7

Purity/Quality:

98%,99%, ^*data from raw suppliers

N-Methyl-tert-butylamine ^*data from reagent suppliers

Safty Information:

• Pictogram(s): C,F
• Hazard Codes: F,C
• Statements: 11-20/21/22-34
• Safety Statements: 26-36/37/39-45

MSDS Files:

Useful:

• Canonical SMILES: CC(C)(C)NC
• Uses: N-tert-Butylmethylamine may be used in the preparation of 3-benzyl-N-tert-butyl-N,3-dimethyl-2,3-dihydrobenzofuran-6-carboxamide. N-tert-Butylmethylamine (N-Methyl-tert-butylamine) may be used in the preparation of 2-(α-N-methyl-tert-butylaminobenzyl)-1-indenone.

Technology Process of N-Methyl-tert-butylamine

There total 26 articles about N-Methyl-tert-butylamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

methanol (67-56-1) + 1-tert-butyl-1-methyl-3-phenylurea (105105-35-9) → N-methyl-tert-butylamine (14610-37-8) + N-phenyl methyl carbamate (2603-10-3)

Guidance literature:

at 50 ℃; for 1h;

DOI:10.1002/anie.200904435

Reference yield: 84.0%

N-benzylidene tert-butylamine (6852-58-0) → N-methyl-tert-butylamine (14610-37-8)

Guidance literature:

With dimethyl sulfate; In toluene; at 85 - 90 ℃; for 2h; Inert atmosphere;

Reference yield: 54.0%

Benzylsulfanylmethyl-tert-butyl-amine; hydrochloride → N-methyl-tert-butylamine (14610-37-8)

Guidance literature:

With lithium aluminium tetrahydride; In diethyl ether; -60 degC -> room temp.;

DOI:10.1039/c39840001334

upstream raw materials:

tert-butylisonitrile

benzylidene-tert-butyl-methyl-ammonium; iodide

formaldehyd

tert-butylamine

Downstream raw materials:

1-tert-butyl-1-methyl-3-phenylurea

2-(tert-Butyl-methyl-amino)-1-phenyl-propan-1-one

C₁₂H₁₈N₄O

Diphenylmethane

Refernces

• 1、 Borisova, I. A.,Shiryaev, A. K.,Shiryaev, V. A.. "Synthesis of 4-Substituted N-Alkyl-1,3-dithiolan-2-imines". . p. 1084 - 1088. Retrieved 2021/09/08.
• 2、 Fang, Chi,Lu, Chunlei,Liu, Muhua,Zhu, Yiling,Fu, Yao,Lin, Bo-Lin. "Selective formylation and methylation of amines using carbon dioxide and hydrosilane catalyzed by alkali-Metal carbonates". . p. 7876 - 7881. Retrieved 2018/05/23.