4-bromoquinoline

Base Information

• Chemical Name: 4-bromoquinoline
• CAS No.: 850917-90-7
• Molecular Formula: C₉H₆BrN
• Molecular Weight: 208.057
• Mol file: 850917-90-7.mol

Synonyms:4-Bromchinolin;

Chemical Property of 4-bromoquinoline

Chemical Property:

• Boiling Point: 295.911 °C at 760 mmHg
• Flash Point: 132.763 °C
• Density: 1.565 g/cm³

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-bromoquinoline

There total 13 articles about 4-bromoquinoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

quinolin-4-ol (611-36-9) → 4-bromoquinoline (3964-04-3,850917-90-7)

Guidance literature:

With boron tribromide; In N,N-dimethyl-formamide; Inert atmosphere;

DOI:10.1021/ja3001979

Reference yield: 86.9%

quinoline (91-22-5) → 4-bromoquinoline (3964-04-3,850917-90-7)

Guidance literature:

With N-Bromosuccinimide; In ethanol; at 20 - 50 ℃; for 3.5h; Reagent/catalyst;

Reference yield: 48.0%

Quinoline N-oxide (1613-37-2) → 2-bromoquinoline (2005-43-8) + 4-bromoquinoline (3964-04-3,850917-90-7)

Guidance literature:

With N,N-dimethyl-formamide; phosphorus(V) oxybromide; In dichloromethane; at 0 - 25 ℃; for 6h; Reagent/catalyst; Solvent; regioselective reaction; Inert atmosphere;

DOI:10.1016/j.tet.2016.07.083

upstream raw materials:

4-aminoquinoline

4-nitroquinoline-N-oxide

4(1H)-quinolinone

4-bromoquinoline-N-oxide

Downstream raw materials:

4-(difluoromethyl)quinoline

11H-indolo[3,2-c]quinoline

Refernces

• 1、 -. "3,6-DISUBSTITUTED-2-PYRIDINALDOXIME SCAFFOLDS". Paragraph 0095; 0132-0134. . Retrieved 2020/08/27.
• 2、 Wang, Dong,Wang, Yuxi,Zhao, Junjie,Li, Linna,Miao, Longfei,Wang, Dong,Sun, Hua,Yu, Peng. "A highly practical and convenient halogenation of fused heterocyclic N-oxides". . p. 5762 - 5768. Retrieved 2016/08/30.