4-(difluoromethyl)quinoline

Base Information

• Chemical Name: 4-(difluoromethyl)quinoline
• CAS No.: 1186194-77-3
• Molecular Formula: C₁₀H₇F₂N
• Molecular Weight: 179.169
• Mol file: 1186194-77-3.mol

Synonyms:4-(difluoromethyl)quinoline

Chemical Property of 4-(difluoromethyl)quinoline

Chemical Property:

Purity/Quality:

97% ^*data from raw suppliers

4-(Difluoromethyl)quinoline 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-(difluoromethyl)quinoline

There total 12 articles about 4-(difluoromethyl)quinoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

quinoline-4-carboxaldehyde (4363-93-3) → 4-(difluoromethyl)quinoline (1186194-77-3)

Guidance literature:

With potassium fluoride; formic acid; tetramethylammonium fluoride; N,N`-sulfuryldiimidazole; In N,N-dimethyl-formamide; at 25 ℃; for 4h; Reagent/catalyst; Inert atmosphere;

DOI:10.1021/acs.orglett.9b00054

Reference yield: 96.0%

→ 4-(difluoromethyl)quinoline (1186194-77-3)

Guidance literature:

With potassium fluoride; formic acid; tetramethylammonium fluoride; N,N`-sulfuryldiimidazole; In N,N-dimethyl-formamide; at 20 ℃; for 4h; Inert atmosphere;

Reference yield: 91.5%

[1,3-bis[2,6-bis(1-methylethyl)phenyl]-2-imidazolidinylidene](difluoromethyl)silver + 4-bromoquinoline (3964-04-3,850917-90-7) → 4-(difluoromethyl)quinoline (1186194-77-3)

Guidance literature:

With bis[2-(diphenylphosphino)phenyl] ether; bis(dibenzylideneacetone)-palladium⁽⁰⁾; In toluene; at 80 ℃; Inert atmosphere;

DOI:10.1039/c7sc00691h

upstream raw materials:

quinoline

2,2-difluoro-1-phenylethanone

4-bromoquinoline

sodium difluoromethanesulfinate

Refernces

• 1、 -. "PROCESSES FOR FLUORINATION". Paragraph 0179; 0184-0187; 0210. . Retrieved 2021/04/10.
• 2、 -. "PROCESSES FOR FLUORINATION". Paragraph 0188. . Retrieved 2020/03/05.