2,5-Dimethoxy-4-methylphenethylamine

Base Information

• Chemical Name: 2,5-Dimethoxy-4-methylphenethylamine
• CAS No.: 24333-19-5
• Molecular Formula: C11H17NO2
• Molecular Weight: 195.261
• UNII: 7J43GY6ONS
• DSSTox Substance ID: DTXSID10179074
• Nikkaji Number: J50.038K
• Wikipedia: 2C-D
• Wikidata: Q209260
• ChEMBL ID: CHEMBL124049
• Mol file: 24333-19-5.mol

Synonyms:2,5-dimethoxy-4-methyl-beta-phenethylamine;2,5-DMP cpd

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Chemical Property of 2,5-Dimethoxy-4-methylphenethylamine

Chemical Property:

• Vapor Pressure: 0.000965mmHg at 25°C
• Refractive Index: 1.516
• Boiling Point: 302.845 °C at 760 mmHg
• PKA: 9.73±0.10(Predicted)
• Flash Point: 149.312 °C
• PSA: 44.48000
• Density: 1.027 g/cm³
• LogP: 2.21370
• XLogP3: 1.8
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 4
• Exact Mass: 195.125928785
• Heavy Atom Count: 14
• Complexity: 163

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC1=CC(=C(C=C1OC)CCN)OC

Technology Process of 2,5-Dimethoxy-4-methylphenethylamine

There total 5 articles about 2,5-Dimethoxy-4-methylphenethylamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2,5-dimethoxy-4-methylbenzaldehyde (4925-88-6) → alpha demethyl DOM (24333-19-5)

Guidance literature:

Multi-step reaction with 2 steps

1: NH₄OAc / benzene

2: LiAlH₄ / tetrahydrofuran

With lithium aluminium tetrahydride; ammonium acetate; In tetrahydrofuran; benzene;

DOI:10.1021/jm00295a034

Reference yield:

2,5-dimethoxy-4-methylphenyl-acetonitrile (53582-10-8) → alpha demethyl DOM (24333-19-5)

Guidance literature:

With diborane; In tetrahydrofuran;

DOI:10.1021/jm00234a010

Reference yield:

1-(2,5-dimethoxy-4-methylphenyl)-2-nitroethene (25505-64-0) → alpha demethyl DOM (24333-19-5)

Guidance literature:

With lithium aluminium tetrahydride; In tetrahydrofuran;

DOI:10.1021/jm00295a034

upstream raw materials:

2,5-dimethoxy-4-methylphenyl-acetonitrile

1-(2,5-dimethoxy-4-methylphenyl)-2-nitroethene

2,5-dimethoxy-4-methylbenzaldehyde

2,5-dimethoxy toluene

Downstream raw materials:

2,5-Dimethoxy-N,N,4-trimethyl-β-phenethylamin

N-Methyl-2-(2',5'-Dimethoxy-4'-methylphenyl)ethylamin

2-(2,5-Dihydroxy-4-methyl-phenyl)-ethylamin

Refernces

• 1、 Ho,Tansey,Balster,An,McIsaac,Harris. "Amphetamine analogs. II. Methylated phenethylamines.". . p. 134 - 135. Retrieved 2007/10/06.