2,5-Dimethoxy-N,4-dimethylbenzeneethanamine

Base Information

• Chemical Name: 2,5-Dimethoxy-N,4-dimethylbenzeneethanamine
• CAS No.: 24286-43-9
• Molecular Formula: C12H19 N O2
• Molecular Weight: 209.2848
• Mol file: 24286-43-9.mol

Synonyms:Phenethylamine,2,5-dimethoxy-N,4-dimethyl- (8CI);N-Methyl-2-(2',5'-dimethoxy-4'-methylphenyl)ethylamine

Chemical Property of 2,5-Dimethoxy-N,4-dimethylbenzeneethanamine

Chemical Property:

• Vapor Pressure: 0.00078mmHg at 25°C
• Boiling Point: 306.3°Cat760mmHg
• Flash Point: 126.7°C
• PSA: 30.49000
• Density: 0.987g/cm³
• LogP: 2.16500

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2,5-Dimethoxy-N,4-dimethylbenzeneethanamine

There total 3 articles about 2,5-Dimethoxy-N,4-dimethylbenzeneethanamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

1-(2,5-Dimethoxy-4-methyl-phenyl)-2-methylamino-ethanol; hydrochloride → N-Methyl-2-(2',5'-Dimethoxy-4'-methylphenyl)ethylamin (24286-43-9)

Guidance literature:

With perchloric acid; hydrogen; palladium on activated charcoal; In acetic acid; for 9h; under 3102.9 Torr;

DOI:10.1021/jm00249a010

Reference yield:

2,5-dimethoxy-4-methylbenzaldehyde (4925-88-6) → N-Methyl-2-(2',5'-Dimethoxy-4'-methylphenyl)ethylamin (24286-43-9)

Guidance literature:

Multi-step reaction with 3 steps

1: NH₄OAc / benzene

2: LiAlH₄ / tetrahydrofuran

3: (i) PhCHO, benzene, (ii) /BRN= 635994/, (iii) H₂O

With lithium aluminium tetrahydride; ammonium acetate; In tetrahydrofuran; benzene;

DOI:10.1021/jm00295a034

Reference yield:

alpha demethyl DOM (24333-19-5) + dimethyl sulfate (77-78-1) → N-Methyl-2-(2',5'-Dimethoxy-4'-methylphenyl)ethylamin (24286-43-9)

Guidance literature:

Multistep reaction; (i) PhCHO, benzene, (ii) /BRN= 635994/, (iii) H₂O;

DOI:10.1021/jm00295a034

upstream raw materials:

alpha demethyl DOM

dimethyl sulfate

2,5-dimethoxy-4-methylbenzaldehyde

Downstream raw materials:

3-{[2-(2,5-Dimethoxy-4-methyl-phenyl)-ethyl]-methyl-amino}-N,N-diethyl-propionamide

Refernces