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Epigenetic Reader Domain inhibitors

Epigenetic reader domain inhibitors are compounds designed to target and inhibit proteins that contain specific reader domains responsible for recognizing and interpreting epigenetic marks on histones or DNA. These reader domains play critical roles in interpreting the histone modifications or DNA methylation patterns within chromatin, thereby influencing gene expression and cellular function. By binding to the reader domains, these inhibitors disrupt the interactions between epigenetic readers and their modified substrates, leading to altered chromatin architecture and gene expression profiles. This disruption can affect processes such as cell differentiation, proliferation, and survival, which are often dysregulated in diseases including cancer and developmental disorders.
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