5-HT Receptor modulators
5-HT receptor modulators are pharmacological compounds that alter the activity of serotonin (5-hydroxytryptamine, 5-HT) receptors in the central nervous system and peripheral tissues without directly agonizing or antagonizing them. Serotonin receptors, classified into several subtypes (such as 5-HT1, 5-HT2, 5-HT3, etc.), mediate various physiological functions including mood regulation, gastrointestinal motility, vasoconstriction, and neurotransmission. Modulators can act as agonists, antagonists, or partial agonists at these receptors, depending on the specific subtype and their mechanism of action. Their role involves fine-tuning serotonin receptor function, often aiming to enhance or dampen specific neurotransmitter pathways associated with various medical conditions. For instance, modulators targeting 5-HT2 receptors may regulate serotonin levels implicated in mood disorders like depression, while those acting on 5-HT3 receptors may alleviate nausea and vomiting in chemotherapy patients.
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