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AChR agonist

Acetylcholine receptor (AChR) agonists are pharmacological substances that mimic the action of acetylcholine (ACh) by binding to and activating ACh receptors in the nervous system and peripheral tissues. ACh receptors are categorized into muscarinic receptors (mAChRs) and nicotinic receptors (nAChRs), each playing critical roles in neurotransmission and neuromuscular signaling. Agonists stimulate these receptors, triggering physiological responses similar to those induced by acetylcholine itself. Depending on the receptor subtype targeted, AChR agonists have diverse therapeutic applications. For example, muscarinic receptor agonists like pilocarpine are used to stimulate salivation and treat conditions such as dry mouth (xerostomia), while nicotinic receptor agonists such as nicotine are used for smoking cessation therapies by targeting nAChRs in the brain's reward pathways.
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