26820-65-5

Basic information

• Product Name: N-Ethyl-3-Nitro-2-Pyridinamine
• Synonyms: N-Ethyl-3-Nitro-2-Pyridinamine;2-Pyridinamine, N-ethyl-3-nitro-
• CAS NO: 26820-65-5
• Molecular Formula: C₇H₉N₃O₂
• Molecular Weight: 167.16526
• Mol File: 26820-65-5.mol
• Article Data: 10

Chemical Properties

• Boiling Point: 298.572 °C at 760 mmHg
• Flash Point: 134.372 °C
• Appearance: /
• Density: 1.281 g/cm³
• Vapor Pressure: 0.001mmHg at 25°C
• Refractive Index: 1.608
• PKA: 2.84±0.10(Predicted)
• CAS DataBase Reference: N-Ethyl-3-Nitro-2-Pyridinamine(CAS DataBase Reference)
• NIST Chemistry Reference: N-Ethyl-3-Nitro-2-Pyridinamine(26820-65-5)
• EPA Substance Registry System: N-Ethyl-3-Nitro-2-Pyridinamine(26820-65-5)

Safety Data

• Hazardous Substances Data: 26820-65-5(Hazardous Substances Data)

Usage

General Description

N-Ethyl-3-Nitro-2-Pyridinamine is a chemical compound with the molecular formula C7H8N4O2. It is an organic compound that is commonly used in the manufacturing of various pharmaceuticals and agrochemicals. The compound is a pale yellow solid and is soluble in organic solvents. It is known for its nitro group, which makes it a useful intermediate in the synthesis of other complex organic compounds. N-Ethyl-3-Nitro-2-Pyridinamine is often used as a building block in the production of drugs and crop protection products. It is important to handle this compound carefully, as it can be harmful if ingested or inhaled.

InChI:InChI=1/C7H9N3O2/c1-2-8-7-6(10(11)12)4-3-5-9-7/h3-5H,2H2,1H3,(H,8,9)

Upstream product

• 5470-18-8 2-Chloro-3-nitropyridine 
• 75-04-7 ethylamine 

Downstream Products

• 32282-06-7 3-amino-2-(ethylamino)pyridine 
• 1399050-23-7 N₂-ethyl-N₃-phenylpyridine-2,3-diamine 
• 1399050-24-8 3-chloro-3-ethyl-1-phenyl-2,3-dihydro-1H-imidazo[4,5-b]pyridine-3-ium-2-ide 
• 1028254-47-8 2-(2-Amino-phenylethynyl)-5-ethyl-10-methyl-5,10-dihydro-4,5,6,10-tetraaza-dibenzo[a,d]cyclohepten-11-one 
• 1026854-16-9 5-Ethyl-10-methyl-2-o-tolylethynyl-5,10-dihydro-4,5,6,10-tetraaza-dibenzo[a,d]cyclohepten-11-one 
• 1026873-42-6 2-[(E)-2-(4-Amino-phenyl)-vinyl]-5-ethyl-10-methyl-5,10-dihydro-4,5,6,10-tetraaza-dibenzo[a,d]cyclohepten-11-one 
• 189393-20-2 5,11-Dihydro-11-ethyl-5-methyl-8-phenylethynyl-6H-dipyrido[3,2-b:2',3'-e]-[1,4]diazepin-6-one 

Relevant articles and documents

Exploiting the anti-HIV 6-desfluoroquinolones to design multiple ligands

It is getting clearer that many drugs effective in different therapeutic areas act on multiple rather than single targets. The application of polypharmacology concepts might have numerous advantages especially for disease such as HIV/AIDS, where the rapid emergence of resistance requires a complex combination of more than one drug. In this paper, we have designed three hybrid molecules combining WM5, a quinolone derivative we previously identified as HIV Tat-mediated transcription (TMT) inhibitor, with the tricyclic core of nevirapine and BILR 355BS (BILR) non-nucleoside reverse transcriptase inhibitors (NNRTIs) to investigate whether it could be possible to obtain molecules acting on both transcription steps of the HIV replicative cycle. One among the three designed multiple ligands, reached this goal. Indeed, compound 1 inhibited both TMT and reverse transcriptase (RT) activity. Unexpectedly, while the anti-TMT activity exerted by compound 1 resulted into a selective inhibition of HIV-1 reactivation from latently infected OM10.1 cells, the anti-RT properties shown by all of the synthesized compounds did not translate into an anti-HIV activity in acutely infected cells. Thus, we have herein produced the proof of concept that the design of dual TMT-RT inhibitors is indeed possible, but optimization efforts are needed to obtain more potent derivatives.

PYRIDYL CARBENE PHOSPHORESCENT EMITTERS

Organometallic compounds comprising an imidazole carbene ligand having a N- containing ring fused to the imidazole ring are provided. In particular, the N-containing ring fused to the imidazole ring may contain one nitrogen atom or more than one nitrogen

Non-nucleoside reverse transcriptase inhibitors

Compounds represented by formula I: wherein R1 is H, halogen, (C1-4)alkyl, O(C1-4)alkyl, and haloalkyl; R2 is H or (C1-4)alkyl; R3 is H or (C1-4)alkyl; R4 is (C1-4)alkyl, (C1-4)alkyl(C3-7)cycloalkyl, or (C3-7)cycloalkyl; and Q is a fused phenyl-5 or 6-membered saturated heterocycle having one to two heteroatoms selected from O and N, said Q being optionally substituted with hydroxy, or (C1-4)alkyl which in turn maybe optionally substituted with pyridinyl-N-oxide or C(O)OR wherein R is H or (C1-4)alkyl; or a salt thereof. The compounds have inhibitory activity against Wild Type, and single and double mutants strains, of HIV.