1026854-16-9

Basic information

• Product Name: 5-Ethyl-10-methyl-2-o-tolylethynyl-5,10-dihydro-4,5,6,10-tetraaza-dibenzo[a,d]cyclohepten-11-one
• Synonyms: 5-Ethyl-10-methyl-2-o-tolylethynyl-5,10-dihydro-4,5,6,10-tetraaza-dibenzo[a,d]cyclohepten-11-one
• CAS NO: 1026854-16-9
• Molecular Weight: 368.438
• Mol File: 1026854-16-9.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 5-Ethyl-10-methyl-2-o-tolylethynyl-5,10-dihydro-4,5,6,10-tetraaza-dibenzo[a,d]cyclohepten-11-one(CAS DataBase Reference)
• NIST Chemistry Reference: 5-Ethyl-10-methyl-2-o-tolylethynyl-5,10-dihydro-4,5,6,10-tetraaza-dibenzo[a,d]cyclohepten-11-one(1026854-16-9)
• EPA Substance Registry System: 5-Ethyl-10-methyl-2-o-tolylethynyl-5,10-dihydro-4,5,6,10-tetraaza-dibenzo[a,d]cyclohepten-11-one(1026854-16-9)

Safety Data

• Hazardous Substances Data: 1026854-16-9(Hazardous Substances Data)

Upstream product

• 32282-06-7 3-amino-2-(ethylamino)pyridine 
• 1025965-71-2 5-Ethyl-10-methyl-2-trimethylsilanylethynyl-5,10-dihydro-4,5,6,10-tetraaza-dibenzo[a,d]cyclohepten-11-one 
• 135795-07-2 5,11-dihydro-11-ethyl-5-methyl-8-nitro-6H-dipyrido[3,2-b:2',3'-e][1,4]diazepin-6-one 
• 135795-54-9 2-chloro-N-(2-ethylamino-3-pyridinyl)-5-nitro-3-pyridinecarboxamide 
• 135795-56-1 11-ethyl-8-nitro-5,11-dihydro-6H-dipyrido[3,2-b:2',3'-e][1,4]diazepin-6-one 
• 189392-94-7 5,11-dihydro-11-ethyl-8-iodo-5-methyl-6H-dipyrido[3,2-b:2',3'-e][1,4]diazepin-6-one 
• 135795-10-7 8-amino-5,11-dihydro-11-ethyl-5-methyl-6H-dipyrido[3,2-b:2',3'-e][1,4]diazepin-6-one 
• 5470-18-8 2-Chloro-3-nitropyridine 
• 189393-26-8 5,11-dihydro-11-ethyl-8-ethynyl-5-methyl-6H-dipyrido[3,2-b:2',3'-e][1,4]diazepin-6-one 
• 26820-65-5 ethyl-(3-nitropyridin-2-yl)amine 

Relevant articles and documents

Novel nonnucleoside inhibitors of HIV-1 reverse transcriptase. 7. 8- Arylethyldipyridodiazepinones as potent broad-spectrum inhibitors of wild- type and mutant enzymes

Like other nonnucleoside inhibitors of HIV-1 reverse transcriptase, the dipyridodiazepinone nevirapine (Viramune, 1) selects for drug resistant variants of HIV-1, both in cell culture and in patients. In particular, the mutation of residue 181 from tyrosine to cysteine (Y181C) is associated with resistance to most reported nonnucleoside inhibitors. Introduction of an arylethyl substituent at the 8-position of the tricyclic dipyridodiazepinone skeleton confers enhanced potency against Y181C RT. Several analogues of this series display good broad spectrum potency against a panel of mutant enzymes.