- Tetrahydroxynaphthalene reductase: Catalytic properties of an enzyme involved in reductive asymmetric naphthol dearomatization
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In reduced circumstances: Tetrahydroxynaphthalene reductase shows a broad substrate range including alternate phenolic compounds and cyclic ketones. Structural modeling reveals major enzyme-substrate interactions; C-terminal truncation of the enzyme causes an altered substrate preference, in accordance with stabilization of the substrate by the C-terminal carboxylate (see picture). This effect allows the identification of a homologous enzyme. Copyright
- Schaetzle, Michael A.,Flemming, Stephan,Husain, Syed Masood,Richter, Michael,Guenther, Stefan,Mueller, Michael
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supporting information; body text
p. 2643 - 2646
(2012/05/04)
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- Heteroaryl β-tetralin ureas as novel antagonists of human TRPV1
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We report on a series of α-substituted-β-tetralin-derived and related phenethyl-based isoquinolinyl and hydroxynaphthyl ureas as potent antagonists of the human TRPV1 receptor. The synthesis and Structure-activity relationships (SAR) of the series are described.
- Jetter, Michele C.,Youngman, Mark A.,McNally, James J.,McDonnell, Mark E.,Zhang, Sui-Po,Dubin, Adrienne E.,Nasser, Nadia,Codd, Ellen E.,Flores, Christopher M.,Dax, Scott L.
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p. 6160 - 6163
(2008/03/18)
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- Ionic hydrogenation of dihydroxynaphthalenes with cyclohexane in the presence of aluminum bromide
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Reactions of 1,5-, 1,6-, 1,7-, 2,6-, and 2,7-dihydroxynaphthalenes with cyclohexane in the presence of excess aluminum bromide in methylene bromide quantitatively yield 5-, 6-, and 7-hydroxynaphthalen-1-ones and 6- and 7-hydroxynaphthalen-2-ones, respectively. Tricationic C-protonated complexes are presumed to be reactive intermediates in these processes.
- Ostashevskaya,Koltunov,Repinskaya
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p. 1474 - 1477
(2007/10/03)
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- HYDROXYLATION DU BENZALDEHYDE ET DE CETONES AROMATIQUES PAR LE PEROXYDE D'HYDROGENE EN MILIEU SUPERACIDE
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Benzaldehyde and aromatic ketones are hydroxylated by hydrogen peroxide in SbF5-HF without formation of products arising from Baeyer-Villiger oxidation.
- Gesson, Jean-Pierre,Jacquesy, Jean-Claude,Jouannetaud, Marie-Paule,Morellet, Guy
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p. 3095 - 3098
(2007/10/02)
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