- RECEPTOR TYROSINE KINASE INHIBITORS FOR TREATMENT OF PROTEIN KINASE MODULATION-RESPONSIVE DISEASE OR DISORDER
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Ephrin type receptor tyrosine kinase inhibitors, also known as Eph tyrosine kinase receptor inhibitors, for treating cancer, an inflammatory disease, an autoimmune disease, or a degenerative disease characterized at least in part by the abnormal activity
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Page/Page column 58; 62
(2021/03/19)
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- Efficient synthesis of 2-arylquinazolin-4-amines via a copper-catalyzed diazidation and ring expansion cascade of 2-arylindoles
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Copper-catalyzed synthesis of 2-arylquinazolin-4-amines from readily available 2-arylindoles and TMSN3 has been developed. The mechanism study shows that the domino reaction may involve a free radical diazidation, denitrogenation, intramolecular cyclization and ring expansion sequence.
- Xu, Meng-Meng,Cao, Wen-Bin,Xu, Xiao-Ping,Ji, Shun-Jun
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supporting information
p. 12602 - 12605
(2018/11/20)
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- A Highly Efficient Copper-Catalyzed Three-Component Synthesis of 4-Aminoquinazolines
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A highly efficient copper-catalyzed one-pot protocol is developed for the synthesis of 4-aminoquinazolines from easily available 2-iodo- or 2-bromobenzimidamides, aldehydes, and sodium azide. This one-pot approach proceeds via consecutive copper-catalyzed SNAr substitution, reduction, cyclization, oxidation and tautomerization. The corresponding target products (26 examples) are obtained in 50-90% yield.
- Yang, Lei,Luo, Honghua,Sun, Yan,Shi, Zhenyu,Ni, Kaidong,Li, Fei,Chen, Dongyin
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p. 2535 - 2535
(2017/05/22)
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- Expeditious Synthesis of 2-Phenylquinazolin-4-amines via a Fe/Cu Relay-Catalyzed Domino Strategy
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A highly efficient Fe/Cu relay-catalyzed domino protocol has been developed for the synthesis of 2-phenylquinazolin-4-amines from commercially available ortho-halogenated benzonitriles, aldehydes, and sodium azide. This elegant domino process involved con
- Jia, Feng-Cheng,Zhou, Zhi-Wen,Xu, Cheng,Cai, Qun,Li, Deng-Kui,Wu, An-Xin
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supporting information
p. 4236 - 4239
(2015/09/15)
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- An efficient method to prepare 4-aminoquinazolines: Potential application to conformation-restricted bleomycin analogs
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(Chemical Equation Presented) To enhance the iron-chelating ability of P-3A, 4-aminoquinazolines were designed as conformation-restricted bleomycin analogs. An efficient method was developed to prepare the 4-aminoquinazoline heterocyclic nucleus, which en
- Wei, Zhonglin,Zheng, Lianyou,Dang, Qun,Bai, Xu
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experimental part
p. 1425 - 1429
(2010/03/30)
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- Isoquinoline and quinazoline urea analogues as antagonists for the human-adenosine A3 receptor
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Isoquinoline and quinazoline urea derivatives were found to bind to human adenosine AS receptors. Series of N-phenyl-N'-quinazolin-4-ylurea derivatives and N-phenyl-N'-isoquinolin-1-ylurea derivatives were synthesized and tested in radioligand binding ass
- Van Muijlwijk-Koezen, Jacqueline E.,Timmerman, Henk,Van Der Goot, Henk,Menge, Wiro M. P. B.,Von Drabbe Künzel, Jacobien Frijtag,De Groote, Miriam,Ijzerman, Adriaan P.
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p. 2227 - 2238
(2007/10/03)
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- Microwave enhanced synthesis of 4-aminoquinazolines
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Cyanoaromatic compounds react with anthranilonitrile in a domestic microwave oven affording good yields of the corresponding 4-aminoquinazolines in a very short irradiation time. (C) 2000 Elsevier Science Ltd.
- Seijas, Julio A.,Vázquez-Tato, M. Pilar,Montserrat Martínez
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p. 2215 - 2217
(2007/10/03)
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