- Preparation method of 3 -chloro-5-trifluoromethyl-2-pYRidine methylamine salt
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The invention discloses a preparation method of 3 -chloro-5-trifluoromethyl-2-pYRidine methylamine salt, and the compound is mainly used as an intermediate compound for synthesis of bactericide fluopicolide for preventing and treating diseases caused by oomycete pathogenic bacteria. According to the preparation method, intermediate compounds of all the steps are prepared by intermittent step-by-step reaction, the finally obtained 3 -chloro-5-trifluoromethyl-2-pYRidine methylamine salt compound is reacted with 2, 6-dichlorobenzoyl chloride in the presence of an organic amine and a solvent to prepare the final object fluopicolide; and nucleophilic substitution reaction, imine hydrolysis and decarboxylation reaction are performed in the preparation process to obtain the target product, the reaction conditions are mild, the operation is simple, and the method is relatively suitable for industrial production.
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Paragraph 0024
(2019/04/26)
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- PROCESS FOR THE PREPARATION OF FLUOPICOLIDE
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The present invention relates to an improved process for the preparation of substituted pyridylmethyl- benzamide derivatives of formula (I), in particular 2,6-Dichloro-N-{[3-chloro-5-(trifluoromethyl)-2- pyridyl]methyl}benzamide (Fluopicolide), from subst
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Page/Page column 11; 12
(2019/06/11)
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- CATALYTIC HYDROGENATION OF SUBSTITUTED CYANOPYRIDINES AND PROCESS FOR PREPARING SUBSTITUTED PYRIDYLMETHYLBENZAMIDES
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The present invention relates to novel processes for the preparation of substituted pyridyl- methylbenzamide derivatives of formula (I), in particular 2,6-dichloro-N- {[3-chloro-5-(trifluoromethyl)- 2-pyridyl]methyl}benzamide (Fluopicolide), and for the catalytic hydrogenation of substituted cyanopyridine derivatives, in particular 3-chloro-2-cyano-5-trifluoromethylpyridine [= Py-CN] to the corresponding substituted 2-methylaminopyridine derivatives, in particular 2-aminomethyl-3-chloro-5- trifluoromethylpyridine [= Py-methylamine] or salts thereof in the presence of metal catalysts such as in particular palladium catalysts, catalytic modifiers and acids.
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Page/Page column 51
(2016/12/16)
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