Synthesis and Biological Activity of Methotrexate Analogues with Two Acid Groups and a Hydrophobic Aromatic Ring in the Side Chain
The heretofore unknown γ-(m-carboxylanilide) and γ-(m-boronoanilide) derivatives of methotrexate (MTX) and γ-(m-carboxyanilide) derivatives of aminopterin (AMT) were prepared and tested as inhibitors of dihydrofolate reductase (DHFR) and as inhibitors of
Rosowsky, Andre,Bader, Henry,Freisheim, James H.
p. 574 - 579
(2007/10/02)
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