- Butenafine
- Butenafine hydrochloride
- 101828-21-11-Naphthalenemethanamine,N-[[4-(1,1-dimethylethyl)phenyl]methyl]-N-methyl-
- 10182-84-0Iodonium, diphenyl-
- 101831-36-1Benzeneacetonitrile,2-chloro-a-(4-chlorophenyl)-4-(4,5-dihydro-3,5-dioxo-1,2,4-triazin-2(3H)-yl)-
- 101831-37-2Diclazuril
- 101831-43-0Morpholinium,4-methyl-4-[2-[2-[[2-(1-methylpiperidinio)-2-phenylacetyl]oxy]ethoxy]ethyl]-,iodide (1:2)
- 101831-59-8Ethanone,1-(3,5-dimethyl-4-nitroso-1-piperazinyl)-
- 10183-49-01,4,9,10-Anthracenetetrol,6,7-dichloro-
- 101836-92-41-Naphthalenol,2,4-dinitro-, sodium salt, hydrate (1:1:2)
- 101-83-7Cyclohexanamine,N-cyclohexyl-
Hot Products
- 104987-11-3Tacrolimus
- 141-53-7Sodium formate
- 8001-54-5Quaternary ammonium compounds, alkylbenzyldimethyl, chlorides
- 9003-39-8Povidone
- 10161-34-9Trenbolone acetate
- 402957-28-2Telaprevir
- 68-19-9Cyanocobalamin
- 7631-86-9Silicon dioxide
- 302-79-4Tretinoin
- 77-92-9Citric acid
|
Basic Information |
|
Post buying leads |
|
Suppliers |
| Name |
Butenafine hydrochloride |
EINECS | 642-354-4 |
| CAS No. | 101827-46-7 | Density | 1.032 g/cm3 |
| PSA | 3.24000 | LogP | 6.57130 |
| Solubility | Soluble in methanol, ethanol or chloroform, insoluble in anhydrous acetic acid or acetonitrile, practically insoluble in ether | Melting Point |
210-214 °C |
| Formula | C23H27N.HCl | Boiling Point | 426.1 °C at 760 mmHg |
| Molecular Weight | 353.19 | Flash Point | 187.7 °C |
| Transport Information | N/A | Appearance | White crystalline powder |
| Safety | 44 | Risk Codes | 21 |
| Molecular Structure |
|
Hazard Symbols | Xn |
| Synonyms |
N-(p-tert-Butylbenzyl)-N-methyl-1-naphthalenemethylamine hydrochloride;Butenafine hydrochloride (JAN/USAN);Butenafine HCl;1-Naphthalenemethanamine, N-((4-(1,1-dimethylethyl)phenyl)methyl)-N-methyl-, hydrochloride;1-(4-tert-Butylphenyl)-N-methyl-N-(1-naphthylmethyl)methanamine hydrochloride (1:1);1-(4-tert-butylphenyl)-N-methyl-N-(naphthalen-1-ylmethyl)methanamine hydrochloride;1-(4-tert-butylphenyl)-N-methyl-N-(naphthalen-1-ylmethyl)methanamine hydrochloride (1:1);1-(4-tert-Butylphenyl)-N-methyl-N-(naphthalen-1-ylmethyl)methanaminhydrochlorid;1-[4-(1,1-diméthyléthyl)phényl]-N-méthyl-N-(naphtalén-1-ylméthyl)méthanamine chlorhydrate;1-naphthalenemethanamine, N-[[4-(1,1-dimethylethyl)phenyl]methyl]-N-methyl-, hydrochloride;1-naphthalenemethanamine, N-[[4-(1,1-dimethylethyl)phenyl]methyl]-N-methyl-, hydrochloride (1:1); |
Butenafine hydrochloride Specification
The Butenafine HCl with CAS registry number of 101827-46-7 is also known as N-(p-tert-Butylbenzyl)-N-methyl-1-naphthalenemethylamine hydrochloride. The IUPAC name is 1-(4-tert-Butylphenyl)-N-methyl-N-(naphthalen-1-ylmethyl)methanamine hydrochloride. It belongs to product categories of Active Pharmaceutical Ingredients; Antifungals for Research and Experimental Use; Biochemistry; Butenafine. In addition, the formula is C23H27N.HCl and the molecular weight is 353.19. This chemical is a white crystalline powder and soluble in methanol, ethanol or chloroform, insoluble in anhydrous acetic acid or acetonitrile, practically insoluble in ether. What's more, it is used as an antifungal to control dermal fungal infections such as athletes foot and ring worm.
Physical properties about Butenafine HCl are: (1)ACD/LogP: 6.77; (2)# of Rule of 5 Violations: 1; (3)#H bond acceptors: 1; (4)#Freely Rotating Bonds: 5; (5)Polar Surface Area: 3.24Å2; (6)Flash Point: 187.7 °C; (7)Enthalpy of Vaporization: 68.08 kJ/mol; (8)Boiling Point: 426.1 °C at 760 mmHg; (9)Vapour Pressure: 1.82E-07 mmHg at 25 °C.
Preparation of Butenafine HCl: it is prepared by reaction of N-methyl-1-naphthalene methylamine hydrochloride with tert-Butyl benzyl bromide. The reaction needs reagent sodium carbonate and solvent dimethylformamide at the temperature of 30-40 °C for 5 hours. The yield is about 94%.
You can still convert the following datas into molecular structure:
1. Canonical SMILES: CC(C)(C)C1=CC=C(C=C1)CN(C)CC2=CC=CC3=CC=CC=C32.Cl
2. InChI: InChI=1S/C23H27N.ClH/c1-23(2,3)21-14-12-18(13-15-21)16-24(4)17-20-10-7-9-19-8-5-6-11-22(19)20;/h5-15H,16-17H2,1-4H3;1H
3. InChIKey: LJBSAUIFGPSHCN-UHFFFAOYSA-N
The toxicity data is as follows:
| Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
|---|---|---|---|---|---|
| dog | LD50 | oral | > 5gm/kg (5000mg/kg) | SENSE ORGANS AND SPECIAL SENSES: LACRIMATION: EYE BEHAVIORAL: ATAXIA GASTROINTESTINAL: NAUSEA OR VOMITING | Kiso to Rinsho. Clinical Report. Vol. 24, Pg. 1551, 1990. |
| dog | LD50 | skin | > 100mg/kg (100mg/kg) | Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 23, Pg. 201, 1992. | |
| mouse | LD50 | intravenous | > 140mg/kg (140mg/kg) | Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 23, Pg. 201, 1992. | |
| mouse | LD50 | oral | > 5gm/kg (5000mg/kg) | SENSE ORGANS AND SPECIAL SENSES: LACRIMATION: EYE LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION | Kiso to Rinsho. Clinical Report. Vol. 24, Pg. 1539, 1990. |
| mouse | LD50 | skin | > 800mg/kg (800mg/kg) | Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 23, Pg. 201, 1992. | |
| mouse | LD50 | subcutaneous | > 200mg/kg (200mg/kg) | Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 23, Pg. 201, 1992. | |
| rat | LD50 | intravenous | > 100mg/kg (100mg/kg) | SENSE ORGANS AND SPECIAL SENSES: LACRIMATION: EYE LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION | Kiso to Rinsho. Clinical Report. Vol. 24, Pg. 1539, 1990. |
| rat | LD50 | oral | > 4gm/kg (4000mg/kg) | Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 23, Pg. 201, 1992. | |
| rat | LD50 | skin | > 1gm/kg (1000mg/kg) | Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 23, Pg. 201, 1992. | |
| rat | LD50 | subcutaneous | > 150mg/kg (150mg/kg) | Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 23, Pg. 201, 1992. | |
| rat | LDLo | intraperitoneal | 1gm/kg (1000mg/kg) | SENSE ORGANS AND SPECIAL SENSES: LACRIMATION: EYE LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION | Kiso to Rinsho. Clinical Report. Vol. 24, Pg. 2589, 1990. |
What can I do for you?
Get Best Price
