- Benzidine
- Benzidine dihydrochloride
- Benzidine sulfate
- Benzidine sulphate
- Benzidine-2,2'-disulphonic acid
- Benzidine-3-sulfuric acid
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Cas Database |
| Name |
Benzidine dihydrochloride |
EINECS | 208-519-6 |
| CAS No. | 531-85-1 | Density | 1.156g/cm3 |
| PSA | 52.04000 | LogP | 5.28440 |
| Solubility | 0.1-0.5 g/100 mL at 23.5 ºC in water | Melting Point |
>300 ºC |
| Formula | C12H12 N2 . 2 Cl H | Boiling Point | 358.7°Cat760mmHg |
| Molecular Weight | 257.163 | Flash Point | 203.5°C |
| Transport Information | UN 2811 | Appearance | WHITE TO OFF-WHITE POWDER |
| Safety | 53-45-60-61 | Risk Codes | R45;R22;R50/53 |
| Molecular Structure |
|
Hazard Symbols |
 
|
| Synonyms |
Benzidine,dihydrochloride (8CI); [1,1'-Biphenyl]-4,4'-diamine, dihydrochloride (9CI) |
Article Data | 2 |
Benzidine dihydrochloride Synthetic route
- 473-34-7
N,N-dichloro-p-toluenesulfonamide
- 67-66-3
chloroform
- 122-66-7
diphenyl hydrazine
A
- 531-85-1
benzidine dihydrochloride
B
- 70-55-3
toluene-4-sulfonamide
C
- 17082-12-1
trans-azobenzene
| Conditions | Yield |
|---|---|
| With hydrogenchloride In water |
| Conditions | Yield |
|---|---|
| In ethanol; water for 2h; Reflux; | 82% |
| Conditions | Yield |
|---|---|
| Stage #1: benzidine dihydrochloride With hydrogenchloride; water; sodium nitrite at 0℃; Diazotization; Stage #2: azulene With sodium acetate In ethanol at 20℃; for 0.5h; Arylation; | 78% |
| Stage #1: benzidine dihydrochloride With hydrogenchloride; water; sodium nitrite at 0℃; Diazotization; Stage #2: azulene With sodium acetate In ethanol at 20℃; for 0.5h; Arylation; Further stages.; | 78% |
| Conditions | Yield |
|---|---|
| Stage #1: benzidine dihydrochloride With hydrogenchloride; sodium nitrite In water at 0 - 5℃; Stage #2: 5-hydroxy-3-methyl-1-(pyrid-2-yl)-1H-pyrazole With sodium hydroxide; aluminium trichloride In water for 0.5h; pH=8.0 - 8.5; cooling; | 77% |
- 531-85-1
benzidine dihydrochloride
- 13024-90-3
1-(4-chlorophenyl)-3-methyl-2-pyrazolin-5-one
| Conditions | Yield |
|---|---|
| Stage #1: benzidine dihydrochloride With hydrogenchloride; sodium nitrite In water at 0 - 5℃; Stage #2: 1-(4-chlorophenyl)-3-methyl-2-pyrazolin-5-one With sodium hydroxide; aluminium trichloride In water for 0.5h; pH=8.0 - 8.5; cooling; | 76% |
| Conditions | Yield |
|---|---|
| Stage #1: benzidine dihydrochloride With hydrogenchloride; sodium nitrite In water at 0 - 5℃; Stage #2: 1-(4-methoxyphenyl)-3-methyl-2-pyrazolin-5-one With sodium hydroxide; aluminium trichloride In water for 0.5h; pH=8.0 - 8.5; cooling; | 71% |
- 24424-99-5
di-tert-butyl dicarbonate
- 531-85-1
benzidine dihydrochloride
| Conditions | Yield |
|---|---|
| With 4-methyl-morpholine; dmap In 1,2-dimethoxyethane at 55℃; for 40h; | 64% |
| Conditions | Yield |
|---|---|
| In methanol; water at 20℃; | 58% |
| Conditions | Yield |
|---|---|
| In methanol excess of CdCl2 with 2 drops of concd.HCl in CH3OH added to soln. of ligand in CH3OH, stirred for 0.5 h; filtered, crystd., XRD; | 52% |
Benzidine dihydrochloride Chemical Properties
IUPAC Name: 4-(4-Aminophenyl)aniline dihydrochloride
The molecular formula of Benzidine dihydrochloride (CAS NO.531-85-1) is C12H14Cl2N2.
The molecular weight of Benzidine dihydrochloride (CAS NO.531-85-1) is 257.16.
Synonyms of Benzidine dihydrochloride (CAS NO.531-85-1): Benzidine dihydrochloride ; 4,4'-Biphenyldiamine dihydrochloride
Product Categories: Intermediates of Dyes and Pigments
Apperance: White crystalline powder
Enthalpy of Vaporization: 60.43 kJ/mol
Water Solubility: 0.1-0.5 g/100 mL
Flash Point: 203.5 °C
Boiling Point: 358.7 °C
Melting Point: ≥300 °C
EINECS: 208-519-6
Benzidine dihydrochloride Uses
Benzidine dihydrochloride (CAS NO.531-85-1) is used as part of a test for cyanide and also in the synthesis of dyes.
Benzidine dihydrochloride Toxicity Data With Reference
| 1. | mmo-sat 100 nmol/plate | MUREAV Mutation Research. 136 (1984),33. | ||
| 2. | sce-ham-ipr 12,500 µg/kg | MUREAV Mutation Research. 113 (1983),33. |
Benzidine dihydrochloride Consensus Reports
Reported in EPA TSCA Inventory. EPA Genetic Toxicology Program.
Benzidine dihydrochloride Safety Profile
Suspected carcinogen with experimental carcinogenic and tumorigenic data. Human mutation data reported. When heated to decomposition it emits very toxic fumes of HCl and NOx.Safety information of Benzidine dihydrochloride (CAS NO.531-85-1):
Hazard Codes 
T,
N,
Xn
Risk Statements 50/53-36/37/38-20/21/22
R20/21/22:Harmful by inhalation, in contact with skin and if swallowed.
R36/37/38:Irritating to eyes, respiratory system and skin.
R50/53:Very toxic to aquatic organisms, may cause long-term adverse effects in the aquatic environment.
Safety Statements 53-45-60-61
S45:In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.)
S60:This material and its container must be disposed of as hazardous waste.
S61:Avoid release to the environment. Refer to special instructions / safety data sheets.
S53:Avoid exposure - obtain special instructions before use.
RIDADR UN 2811 6.1/PG 2
WGK Germany 3
RTECS DD0600000
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